A study performed in Barcelona has revealed a new method for protein tagging that preserves protein native functions and structure.
The healthy development of an organism depends on its tissues and organs growing to the right size, stopping when they need to, and maintaining stability in their form and function.
The group led by ICREA Research Professor Cayetano Gonzalez at IRB Barcelona, in collaboration with the group of Professor Giuliano Callaini from the University of
The protein E-Cadherin (E-Cad) is a kind of adhesive that keeps cells tightly bound together, thus favouring the organisation of tissues and organs.
Nature Middle East
The journal Nature Middle East has interviewed Modesto Orozco, group leader at IRB Barcelona, Director of Life Sciences at the BSC-CNS, and Professor at the UB. Orozco talks about the recent publication in Nature Methods of a study on inntags, a new method developed in collaboration with CSIC, IRB Barcelona, BSC and UB to study proteins.
El Punt Avui & other media
Various media, including the newspaper “El Punt Avui”, have echoed the study published in PLoS Biology by Marco Milán, ICREA researcher and group leader of the Development and Growth Control Laboratory at IRB Barcelona, and Ana Ferreira, PhD student from the same laboratory.
Generalitat de Catalunya
The non-profit association “Vi per Vida” (“Wine for Life”), an initiative launched by sommelier Xavier Ayala to boost research into cancer and metastasis, will be the beneficiary of the funds raised with the “solidarity hat” at the 35th Wines and Cavas of Catalonia Fair, to be held from 19 and 24 September at the Arc de Triomf in Barcelona.
«Our study highlights the complexity of p38 functions, both in cancer and in the maintenance of normal tissues. It shows why an inhibitor of this molecule could effectively have undesirable side effects. But these do not exclude it from being a target against cancer.»
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«Controlling a biological process from outside is the future of chemistry and opens up promising roads for advancements in pharmacological research.»
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«98% of the potential therapeutic molecules against diseases of the central nervous system cannot cross the blood-brain barrier. We develop peptides with the capacity to open the doors of the barrier and act as shuttles when attached to a therapeutic molecule.»
Felice Alessio Bava
former PhD student in the Translational Control of Cell Cycle and Differentiation Lab
«We suspected that CPEB1, a protein involved in regulating mRNA translation in the cytoplasm, might also be active in the nucleus and play a role in controlling pre-mRNA processing. We discovered that it affects the alternative generation in the mature mRNA of the 3'-UTR, regions where most of the elements regulating translation in time and space are located.»
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Quick facts about IRB
IRB Barcelona has been awarded the "HR Excellence in Research" logo. This recognition reflects the commitment of the Institute to continuously improving its human resources policies in line with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers. The award confirms the efforts of the Institute to ensure fair and transparent recruitment and appraisal procedures. Click here for more information.
IRB Barcelona is home to nearly 450 research, technical and support staff from 35 countries who share the common goal of contributing to the advancement of the biomedical sciences through investigator–driven research, and improving quality of life by applying advances in this field.
The convergence of biology, chemistry, and structural and computational biology is unique at IRB Barcelona and opens a strategic window to gain insight into basic molecular processes in health and disease.
Research is conducted by 23 groups organized into 5 interdisciplinary programmes. Each programme includes a diverse faculty of researchers with overlapping scientific interests. The research areas have been structured to be highly interactive, fostering multidisciplinarity by combining modern molecular biology, classical genetics, biochemistry, structural biology, bioinformatics, systems biology, advanced microscopy, and genomic and proteomic approaches.