Cell and Developmental BiologyDevelopment and Growth Control Laboratory

Development and Growth Control Laboratory

Marco Milán

Group Leader

ICREA Research Professor

+34 93 40 34902

We are interested in the cellular and molecular mechanisms underlying the regulation of tissue growth during normal development, tissue homeostasis and tumorigenesis. We perform these studies in Drosophila melanogaster, because of its suitability for genetic and molecular manipulations and its well-described developmental biology. Our current work focuses on the following topics:

Growth control during normal development: The wing primordium is a monolayered epithelial sac that grows one-thousand folds in size and number of cells to give rise to the adult wing. It is subdivided into compartments, cell populations that do not mix during the proliferative stages, and interactions between these compartments induce the expression or activity of signaling molecules that organize growth and pattern formation. We are interested in understanding the molecular mechanisms that organize and coordinate growth and patterning, the gene regulatory networks involved in compartment boundary formation and the cellular mechanisms involved in generating the affinity barriers.

Coordination of tissue growth: In multi-cellular organisms, coordination of growth between and within organs contributes to the generation of well proportioned organs and functionally integrated adults and ensures adaptation to environmental conditions. We are currently analyzing the molecular mechanisms involved in these processes, with a particular interest on the role of Drosophila p53 and the micro-RNA machinery.

Drosophila epithelial cells as a model for cancer biology: Wing primordia have provided useful as model systems to elucidate the molecular mechanisms underlying tumorigenic growth. We are interested in identifying the cellular and molecular mechanisms that lead to oncogene-mediated hyperplasic growth, cell delamination, basement membrane degradation and host invasiveness.

Boulan L, Martín D and Milán M.
Curr Biol, 23 (6), 473-8 (2013)
Dekanty A, Barrio L, Muzzopappa M, Auer H, and Milán M
P Natl Acad Sci Usa, 109 (50), 20549-54 (2012)
Duran J, Tevy MF, Garcia-Rocha M, Calbó J, Milán M* and Guinovart JJ*.
EMBO Mol Med, 4 (8), 719-29 (2012)
Mesquita D, Dekanty A and Milán M.
Plos Biol, 8 (12), e1000566 (2010)
Becam I, Fiuza UM, Arias AM and Milán M.
Curr Biol, 20 (6), 554-60 (2010)
Herranz H, Hong X, Pérez L, Ferreira A, Olivieri D, Cohen SM and Milán M.
Embo J, 29 (10), 1688-98 (2010)
Herranz H, Pérez L, Martín FA and Milán M.
Embo J, 27 (11), 1633-45 (2008)

* shared senior authorship

This group receives financial support from the following sources:

  • European Commission
  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Generalitat de Catalunya (DURSI)(Government of Catalonia)
  • ICREA (Catalan Institute of Research and Advanced Studies)
  • EMBO Young Investigator Programme

Group news & mentions

31 Aug 2015

Various media, including the newspaper “El Punt Avui”, have echoed the study published in PLoS Biology by Marco Milán, ICREA researcher and group leader of the Development and Gro

28 Aug 2015

The healthy development of an organism depends on its tissues and organs growing to the right size, stopping when they need to, and maintaining stability in their form and function.

14 Jul 2015

The newspaper “El Periódico de Catalunya” has echoed the award ceremony of the 77 grants given by the “Obra Social La Caixa” foundation to support doctoral students.

18 Jun 2015

“El País” newspaper has published an article on the Barcelona BioMed Conference “Drosophila as a model in cancer”.

Upcoming events

16 Sep

Speaker:Maho Hamasaki, PhD - Associate Professor, Department of Genetics – Graduate School of Medicine – Osaka University - Japan

 

18 Sep

Speaker: Dr. Reuven Agami, Group Leader, Professor of Genetics and Pathology and Head of Division of Gene Regulation. The Netherlands Cancer Institute

 

29 Sep

An ambulance for the brain

 

An event hosted by the Centre de Cultura Contemporània de Barcelona