Cell and Developmental BiologyDevelopment and morphogenesis in Drosophila
Studies on the genetic control of development have proven to be very been fruitful in unveiling the mechanisms impaired in many disease conditions. This is particularly true in the case of cancer and associated illnesses, as can be assessed by the wealth of knowledge obtained from the study of the developmental role of oncogenes and tumour suppressor genes, the studies of cell migration, epithelial-mesenchymal transition and vasculogenesis. In this regard, the focus of our research at the IRB is to advance in providing basic knowledge on the genetic regulation of such developmental processes, and in particular in their control by cell communication mechanisms. Our aim is to study those phenomena in the context of the whole organism and to do so we use Drosophila melanogaster as a tool. The choice of Drosophila as a model system to study the basic phenomena in development has proved to be extremely fruitful. The broad conservation of the developmental key genes identified in Drosophila and the basic similarity between developmental processes in different species justifies the choice of an organism as a model system.
The work of many laboratories has allowed to begin to understand the genetics logic behind development and we are now trying to understand how these mechanisms impinge on cell behaviour. In particular, we put our emphasis on the issue of the supracellular organisation and more precisely on how individual cell changes can generate an upper level of complexity such the one found in tissues and organs. We work in this research field using two Drosophila models already well known in the lab (the transduction pathway specifying the embryonic terminal regions and the tracheal system), as well as another one more recently added (the morphogenesis of the endoderm and gut). We hope that a global approach using these three systems will allow us unveil how transcription factors and signalling pathways trigger and coordinate changes in cell issues such as shape, polarity and adhesion into collective organization and migration. In performing this global approach we also consider an evolutionary perspective that could account for the recruitment of already existing mechanisms into distinct processes or for their particular redeployment to explain appearance of different kinds of supracellular organization. Finally, we hope this approach will be also crucial to provide an understanding of some of the mechanisms involved in disease conditions and in particular in oncogenesis. To this aim, we have fostered our collaboration with some research groups from the oncology programme.
- Analysis of the mechanisms responsible for the localized activation of the Torso receptor tyrosine kinase.
- Analysis of gene expression regulation by the Torso transduction pathway, especially in relation with the inactivation of the capicua repressor.
- Analysis of cell adhesion and cytoskeleton regulation during migration and tube formation in the tracheal system.
- Properties of the collective cell migration.
- The role of GATA factors in the endoderm epithelial-to-mese.nchymal transition (EMT).
* shared senior authorship
This groups is financially supported by:
- Ministerio de Educación y Ciencia (MEC - Spanish Ministry of Science & Education)
Group news & mentions
The fifth edition of the course for secondary school teachers starts at IRB Barcelona
Discovery of nanomolecular scale proteins and reconstruction of tissues in 3D—the most recent advances in microscopy
Microscopy moves towards “nanoscopy” and transforms the life sciences
Discovery of the mechanism that reactivates cells as stem cells
Group news & mentions
Today and tomorrow, 15 secondary school teachers are going to get up to date with scientific concepts at the Institute for Research in Biomedicine (IRB Barcelona) through the course “On the fly”.
Various media, including El Mundo, have echoed the European Light Microscopy Initiative (ELMI) international congress, which has gathered leading experts in microscopy this week in Sitges.
Observing the movement of cells inside an organism, following the development of an embryo in vivo over two days, or seeing how synapses form between neurons are the challenges faced by m
The study by Jordi Casanova and first-authored by postdoctoral fellow Nareg J.-V. Djabrayan at IRB Barcelona, together with researchers at CSIC, has been echoed in the media.
Speaker: Simone Pieretti, IRB Barcelona
Speaker: Jordi Casanova, PhD IRB Barcelona
Speaker: Dr. Jacques Pouysségur, Institute for Research on Cancer and Aging, Nice (IRCAN) - University of Nice, CNRS, Inserm, Centre A. Lacassagne
Speaker: Manuel Valiente, DVM, PhD - Brain Metastasis Group, Molecular Oncology Program, CNIO, Madrid, Spain.