OncologyGrowth control and cancer metastasis

Growth control and cancer metastasis

Roger Gomis

Group Leader

ICREA Research Professor

+34 93 40 39959

Intricate signalling networks control cell division, differentiation, movement, organization and death. Understanding how cells read and transform these signals into changes in cell behaviour is a major research focus of our group. Cancer cells disobey these signals during tumour progression and metastasis. Metastasis is the final step in 90% of all fatal solid tumours.  It is therefore a grave public health problem and consequently a field of considerable pharmaceutical interest.

Growth Control and Cancer Metastasis

Our research centres on how growth factors, signalling pathways, and gene expression programmes control normal cell proliferation and cancer cell metastasis.

We study the ways in which cancer cells evade tumour suppressor mechanisms and engage in metastatic behaviour. We focus on a cytostatic programme involving the transcriptional activation of cell cycle inhibitors and the transcriptional repression of growth-promoting and anti-differentiation factors. Furthermore, we examine how tumour cells evade these gene responses in order to pursue metastatic behaviour. By combining in vivo selection of human metastatic cells, transcriptomic profiling and functional testing, we identify genes that selectively mediate breast metastasis to specific organs. Gene transfer techniques and RNAi-mediated gene silencing are used to functionally validate candidate genes. We are encouraged by the recent validation of these findings in clinical samples. Several of these genes encode products that are susceptible to therapeutic targeting.

Oller-Salvia B, Sánchez-Navarro M, Ciudad S, Guiu M, Arranz-Gibert P, Garcia C, Gomis RR, Cecchelli R, García J, Giralt E and Teixidó M.
Angew Chem Int Edit, 55 (2), 572-5 (2016)
Pavlovic M, Arnal-Estapé A, Rojo F, Bellmunt A, Tarragona M, Guiu M, Planet E, Garcia-Albéniz X, Morales M, Urosevic J, Gawrzak S, Rovira A, Prat A, Nonell L, Lluch A, Jean-Mairet J, Coleman R, Albanell J and Gomis RR.
J Natl Cancer I, 107 (12), (2015)
Urosevic J, Nebreda AR and Gomis RR.
Cell Cycle, 13 (17), 2641-2 (2014)
Morales M, Arenas EJ, Urosevic J, Guiu M, Fernández E, Planet E, Fenwick RB, Fernández-Ruiz S, Salvatella X, Reverter D, Carracedo A, Massagué J and Gomis RR.
EMBO Mol Med, 6 (7), 865-81 (2014)
Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR and Gomis RR.
Nat Cell Biol, 16 (7), 685-94 (2014)

The Growth control and cancer metastasis group receives financial support from the following sources:

  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Asociación Española Contra el Cáncer

Group news & mentions

20 Apr 2016

The newspaper published in Lleida devotes an article to the recent finding made by the researchers Felipe Slebe, Joan Guinovart and Roger Gomis in breast cancer.

6 Apr 2016

Various media channels have explained new research revealing that the division and proliferation of breast tumor cells is dependent on the uptake of lipids (fats) from circulating blood.

<p>Breast tumours have high levels of LIPG expression (F Slebe, IRB Barcelona)</p>
5 Apr 2016

A study headed by the Institute for Research in Biomedicine (IRB Barcelona) and in collaboration with hospitals around Spain and the Universitat Rovira i Virgili (URV) has unveiled breast

Upcoming events

27 May
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Paul L.Fox - Department of Cellular and Molecular Medicine - Lerner Research Institute - Cleveland Clinic - USA
31 May - 02 Jun
ESADE Business School, Pedralbes Campus Avd. Esplugues 92-96, 08034 Barcelona
02 Jun
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Dr. Anna Obenauf. Research Institute of Molecular Pathology (IMP). Vienna (Austria)