OncologyGrowth control and cancer metastasis

Growth control and cancer metastasis
Group Leader

ICREA Research Professor

+34 93 40 39959

Meet Our Scientists Videos

Roger Gomis: "Light and credibility"

Intricate signalling networks control cell division, differentiation, movement, organization and death. Understanding how cells read and transform these signals into changes in cell behaviour is a major research focus of our group. Cancer cells disobey these signals during tumour progression and metastasis. Metastasis is the final step in 90% of all fatal solid tumours.  It is therefore a grave public health problem and consequently a field of considerable pharmaceutical interest.

Growth Control and Cancer Metastasis

Our research centres on how growth factors, signalling pathways, and gene expression programmes control normal cell proliferation and cancer cell metastasis.

We study the ways in which cancer cells evade tumour suppressor mechanisms and engage in metastatic behaviour. We focus on a cytostatic programme involving the transcriptional activation of cell cycle inhibitors and the transcriptional repression of growth-promoting and anti-differentiation factors. Furthermore, we examine how tumour cells evade these gene responses in order to pursue metastatic behaviour. By combining in vivo selection of human metastatic cells, transcriptomic profiling and functional testing, we identify genes that selectively mediate breast metastasis to specific organs. Gene transfer techniques and RNAi-mediated gene silencing are used to functionally validate candidate genes. We are encouraged by the recent validation of these findings in clinical samples. Several of these genes encode products that are susceptible to therapeutic targeting.

2. Martín-Martín N, Piva M, Urosevic J, Aldaz-Donamaria, P, Sutherland JD, Arreal, L, Fenandez-Ruiz, S, Torrano V, Cortazar AR, Planet E, Guiu M, Radosevic-Robin N, Garcia S, Macías I, Salvador, F, Domenici, G, Rueda, O, Zabala-Letona A, Arruabarrena
Nat Commun, (2016)
Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, David Sutherland J, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C,
Nat Cell Biol, 18 (6), 645-56 (2016)
Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ and Gomis RR.
Nat Commun, 7 11199 (2016)
Ören B, Urosevic J, Mertens C, Mora J, Guiu M, Gomis RR, Weigert A, Schmid T, Grein S, Brüne B and Jung M.
J Pathol, 239 (3), 274-85 (2016)
Oller-Salvia B, Sánchez-Navarro M, Ciudad S, Guiu M, Arranz-Gibert P, Garcia C, Gomis RR, Cecchelli R, García J, Giralt E and Teixidó M.
Angew Chem Int Edit, 55 (2), 572-5 (2016)
Pavlovic M, Arnal-Estapé A, Rojo F, Bellmunt A, Tarragona M, Guiu M, Planet E, Garcia-Albéniz X, Morales M, Urosevic J, Gawrzak S, Rovira A, Prat A, Nonell L, Lluch A, Jean-Mairet J, Coleman R, Albanell J and Gomis RR.
Jnci-j Natl Cancer I, 107 (12), (2015)
Urosevic J, Nebreda AR and Gomis RR.
Cell Cycle, 13 (17), 2641-2 (2014)
Morales M, Arenas EJ, Urosevic J, Guiu M, Fernández E, Planet E, Fenwick RB, Fernández-Ruiz S, Salvatella X, Reverter D, Carracedo A, Massagué J and Gomis RR.
EMBO Mol Med, 6 (7), 865-81 (2014)
Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR and Gomis RR.
Nat Cell Biol, 16 (7), 685-94 (2014)

The Growth control and cancer metastasis group receives financial support from the following sources:

  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Asociación Española Contra el Cáncer

Group news & mentions

<p>34 researchers have been awarded in the 2016 edition. Today, all the attendees at the ceremony in the AECC institutional act held in Barcelona (Picture: AECC)</p>
22 Sep 2016

Today, Jelena Urosevic and Carles Barceló, postdoctoral fellows at the Institute for Research in Biomedicine (IRB Barcelona), will officially be presented with funding over 5 years

20 Sep 2016

The newspaper ARA publishes an hard copy and digital  interview with the ICREA

20 Apr 2016

The newspaper published in Lleida devotes an article to the recent finding made by the researchers Felipe Slebe, Joan Guinovart and Roger Gomis in breast cancer.

Upcoming events

26 Sep
Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Emil Pai, University of Toronto
30 Sep
Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Sir Philip Cohen, Ph.D. MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences. University of Dundee. Scotland (UK)
03 Oct - 05 Oct
Institut d'Estudis Catalans (IEC), Barcelona