Structural and Computational BiologyStructural Bioinformatics and Network Biology
"For every complex problem there's an answer that is clear, simple, and wrong". H.L. Mencken.
ICREA Research Professor, ERC Consolidator Grant
Modern molecular and cell biology no longer focus only on single macromolecules but now look into pathways, complexes or even entire organisms. The many genome-sequencing projects have provided a near complete list of the components present in an organism, and post-genomic projects have aimed to catalogue the relationships between them.
The emerging field of systems biology is now centered mainly on unravelling these relationships. For example, an understanding of metabolic and signalling pathways or gene-regulatory networks relies on detailed knowledge of protein–metabolite, protein–protein and protein–nucleic-acid interactions. However, a full understanding of how molecules interact can be attained only from three-dimensional (3D) structures, as these provide crucial atomic details about binding. These details allow a more rational design of experiments to disrupt an interaction and therefore to perturb any system in which the interaction is involved.
Our main scientific interests lie in the field of structural bioinformatics, in particular, the use of high-resolution 3D structures to reveal the molecular bases of how macromolecular complexes and cell networks operate. Structural information for interacting cellular components willimprove our understanding of the whole-cell framework at atomic level, thereby contributing to biological systems modelling.
This group receives financial support from the following sources:
- European Commission
- ICREA (Institució Catalana de Recerca i Estudis Avançats)(Catalan Institute of Research and Advanced Studies)
Group news & mentions
A new strategy against the invisible enemy
A computational tool for mapping pathological mutations in the interactome
A computational resource improves the analysis of human tumours
A tool developed at IRB Barcelona to be used by the international consortium Pan-Cancer for the analysis of human tumours
Group news & mentions
Cristina Sáez, a journalist specialised in science, wrote this long article on Alzheimer’s disease, published in The Magazine of La Vanguardia.
The “Gaceta Médica” newspaper has published an article about the computational resource dSysMap, developed by the Laboratory of Structural Bioinformatics and Network Biology at IRB Barcelo
The computational tool developed by the Laboratory of Structural Bioinformatics and Network Biology at IRB Barcelona, led by ICREA researcher Patrick Aloy, associates 23,000 genetic mutations with
Today in the journal Nature Methods, the laboratory headed by ICREA researcher Patrick Aloy, at the Institute for Research in Biomedicine (IRB Barcelona), presents a computational tool tha
Speaker: Manuel Irimia, CRG, Barcelona, Spain
Speaker: Silvia Vilaprinyó, Design, synthesis and structure of peptides and proteins, IRB Barcelona
Speaker: Rick Millane, Department of Electrical and Computer Engineering, University of Canterbury, Christchurch, New Zealand
Speaker: Dr. Jacques Pouysségur, Institute for Research on Cancer and Aging, Nice (IRCAN) - University of Nice, CNRS, Inserm, Centre A. Lacassagne