Structural and Computational BiologyStructural Bioinformatics and Network Biology

"For every complex problem there's an answer that is clear, simple, and wrong". H.L. Mencken.

Structural Bioinformatics and Network Biology

Patrick Aloy

Group Leader

ICREA Research Professor, ERC Consolidator Grant

+34 93 40 39690

Modern molecular and cell biology no longer focus only on single macromolecules but now look into pathways, complexes or even entire organisms. The many genome-sequencing projects have provided a near complete list of the components present in an organism, and post-genomic projects have aimed to catalogue the relationships between them.

The emerging field of systems biology is now centered mainly on unravelling these relationships. For example, an understanding of metabolic and signalling pathways or gene-regulatory networks relies on detailed knowledge of protein–metabolite, protein–protein and protein–nucleic-acid interactions. However, a full understanding of how molecules interact can be attained only from three-dimensional (3D) structures, as these provide crucial atomic details about binding. These details allow a more rational design of experiments to disrupt an interaction and therefore to perturb any system in which the interaction is involved.

Structural Bioinformatics and Network Biology Group Webpage

Our main scientific interests lie in the field of structural bioinformatics, in particular, the use of high-resolution 3D structures to reveal the molecular bases of how macromolecular complexes and cell networks operate. Structural information for interacting cellular components willimprove our understanding of the whole-cell framework at atomic level, thereby contributing to biological systems modelling.

Duran-Frigola M, Rossell D and Aloy P.
Nat Commun, 5 5676 (2014)
Mosca R, Céol A and Aloy P.
Nat Methods, 10 (1), 47-53 (2013)
Duran-Frigola M, Mosca R and Aloy P.
Chem Biol, 20 (5), 674-84 (2013)
Mosca R, Pache RA and Aloy P.
Mol Cell Proteomics, 11 (7), M111.01496 (2012)
Soler-López M, Zanzoni A, Lluís R, Stelzl U and Aloy P.
Genome Res, 21 (3), 364-76 (2011)
Stein A and Aloy P.
Plos Comput Biol, 6 (5), e1000789 (2010)
Sardon T, Pache RA, Stein A, Molina H, Vernos I and Aloy P.
Embo Rep, 11 (12), 977-84 (2010)

This group receives financial support from the following sources:

  • European Commission
  • ICREA (Institució Catalana de Recerca i Estudis Avançats)(Catalan Institute of Research and Advanced Studies)

Group news & mentions

18 May 2015

Cristina Sáez, a journalist specialised in science, wrote this long article on Alzheimer’s disease, published in The Magazine of La Vanguardia.

9 Mar 2015

The “Gaceta Médica” newspaper has published an article about the computational resource dSysMap, developed by the Laboratory of Structural Bioinformatics and Network Biology at IRB Barcelo

3 Mar 2015

The computational tool developed by the Laboratory of Structural Bioinformatics and Network Biology at IRB Barcelona, led by ICREA researcher Patrick Aloy, associates 23,000 genetic mutations with

27 Feb 2015

Today in the journal Nature Methods, the laboratory headed by ICREA researcher Patrick Aloy, at the Institute for Research in Biomedicine (IRB Barcelona), presents a computational tool tha

Upcoming Programme Events

26 May

Tuesday, May 26, 2015 12:30-15.30

27 May

Speaker: Joachim Schulz, KU Leuven, Belgium

27 May

Speaker: Juan Fernández-Recio, Barcelona Supercomputing Center, Spain

 

27 May

From new therapies to personalized medicine. Toward cancer as a chronic condition

 

An event hosted by the Centre de Cultura Contemporània de Barcelona

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