Structural and Computational BiologyStructural Bioinformatics and Network Biology

"For every complex problem there's an answer that is clear, simple, and wrong". H.L. Mencken.

Structural Bioinformatics and Network Biology

Patrick Aloy

Group Leader

ICREA Research Professor

ERC Consolidator Grant

+34 93 40 39690

Modern molecular and cell biology no longer focus only on single macromolecules but now look into pathways, complexes or even entire organisms. The many genome-sequencing projects have provided a near complete list of the components present in an organism, and post-genomic projects have aimed to catalogue the relationships between them.

The emerging field of systems biology is now centered mainly on unravelling these relationships. For example, an understanding of metabolic and signalling pathways or gene-regulatory networks relies on detailed knowledge of protein–metabolite, protein–protein and protein–nucleic-acid interactions. However, a full understanding of how molecules interact can be attained only from three-dimensional (3D) structures, as these provide crucial atomic details about binding. These details allow a more rational design of experiments to disrupt an interaction and therefore to perturb any system in which the interaction is involved.

Structural Bioinformatics and Network Biology Group Webpage

Our main scientific interests lie in the field of structural bioinformatics, in particular, the use of high-resolution 3D structures to reveal the molecular bases of how macromolecular complexes and cell networks operate. Structural information for interacting cellular components willimprove our understanding of the whole-cell framework at atomic level, thereby contributing to biological systems modelling.

Mosca R, Pache RA and Aloy P.
Mol Cell Proteomics, 7 (11), M111.01496 (2012)
Soler-López M, Zanzoni A, Lluís R, Stelzl U and Aloy P.
Genome Res, 3 (21), 364-76 (2011)
Stein A and Aloy P.
Plos Comput Biol, 5 (6), e1000789 (2010)
Sardon T, Pache RA, Stein A, Molina H, Vernos I and Aloy P.
Embo Rep, 12 (11), 977-84 (2010)

Upcoming events

17 Sep

Speaker: Dr. Christoph Thomas,
Institute of Biochemistry, Biocenter Goethe University, Frankfurt, Germany

17 Sep

Speaker: Dr. Friedrich Förster,
Max-Planck Institut fuer Biochemie, Munich, Germany

17 Sep

Speaker: Dr. James Parker,
University of Oxford, UK

Funding

This group receives financial support from the following sources:

  • European Commission
  • ICREA (Institució Catalana de Recerca i Estudis Avançats)(Catalan Institute of Research and Advanced Studies)