Repression of endogenous retroviruses is required for mammary gland development

Alexandra Avgustinova (...) & Salvador Aznar Benitah

Cell Stem Cell (2021) DOI: 10.1016/j.stem.2021.04.030

Bioactivity descriptors for uncharacterized chemical compounds

Martino Bertoni (...) & Patrick Aloy

Nature Communications (2021) DOI: 10.1038/s41467-021-24150-4

Impact of DNA methylation on 3D genome structure

Diana Buitrago (...) Isabelle Brun Heath & Modesto Orozco 

Nature Communications (2021) DOI: 10.1038/s41467-021-23142-8

Probing allosteric regulations with coevolution-driven molecular simulations

Francesco Colizzi & Modesto Orozco

Science Advances (2021) DOI: 10.1126/sciadv.abj0786

Integration of Feeding Behaviour by the Liver Circadian Clock Reveals Network Dependency of Metabolic Rhythms

Carolina M. Greco (...) Salvador Aznar Benitah & Paolo Sassone-Corsi

Science Advancces (2021) DOI: 10.1126/sciadv.abi7828

MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate

Núria Gutierrez-Prat (...) Matthias Gaestel & Angel R. Nebreda

PNAS (2021) DOI: 10.1073/pnas.2024562118

Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

Jery Joy (...) & Marco Milán 

Developmental Cell (2021) DOI: 10.1016/j.devcel.2021.06.009

In silico saturation mutagenesis of cancer genes

Ferran Muiños (...) Abel Gonzalez-Perez & Nuria Lopez-Bigas 

Nature (2021) DOI: 10.1038/s41586-021-03771-1

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers

Solip Park, Fran Supek & Ben Lehner

Nature Communications (2021) DOI: 10.1038/s41467-021-27242-3.

Dietary palmitic acid promotes a metastatic memory via Schwann cells

Gloria Pascual (...) Ali Shilatifard & Salvador Aznar Benitah

Nature (2021) DOI: 10.1038/s41586-021-04075-0

Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-G-F, AppNL-F and 3xTg-AD mouse models

Eduardo Pauls (...) & Patrick Aloy

Genome medicine (2021) DOI: 10.1186/s13073-021-00983-y

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

Marina Pekmezovic (...) Toni Gabaldón & Bernhard Hube

Nature Microbiology (2021) DOI: 10.1038/s41564-021-00875-2

The evolution of hematopoietic cells under cancer therapy

Oriol Pich (...) Abel Gonzalez-Perez & Nuria Lopez-Bigas

Nature Communications (2021) DOI: 10.1038/s41467-021-24858-3

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Alvaro Rol (...) Mario Delgado, Antoni Riera & Maria J. Macias

Nature Communications (2021) DOI: 10.1038/s41467-021-22076-

Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole- stabilizing scaffold

Nina Schweizer (...) & Jens Lüders

Nature Communications (2021) DOI: 10.1038/s41467-021-26252-5

LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions

Selma A Serra (...) Eulàlia de Nadal, Miguel A. Valverde & Francesc Posas 

PNAS (2021) DOI:

Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins

Adrian Gabriel Torres (...) & Lluís Ribas de Pouplana

Nucleic Acids Research (2021) DOI: 10.1093/nar/gkab461

Thank you!

We would like to thank all those who contributed to our achievements in 2021.
Metastasis continues to be responsible for 90% of cancer-related
deaths and our commitment to end it is stronger than ever.