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Investigación

A la vanguardia de la biomedicina

Publicaciones sobre Investigación

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Sati, S; Bonev, B; Szabo, Q; Jost, D; Bensadoun, P; Serra, F; Loubiere, V; Papadopoulos, GL; Rivera-Mulia, JC; Fritsch, L; Bouret, P; Castillo, D; Gelpi, JLI; Orozco, M; Vaillant, C; Pellestor, F; Bantignies, F; Marti-Renom, MA; Gilbert, DM; Lemaitre, JM; Cavalli, G
MOLECULAR CELL
78
3
522 -
2020
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
Sridhar, A; Farr, SE; Portella, G; Schlick, T; Orozco, M; Collepardo-Guevara, R
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
117
13
7216 -
7224
2020
Synthesis and Application of 3-Bromo-1,2,4,5-Tetrazine for Protein Labeling to Trigger Click-to-Release Biorthogonal Reactions
Ros, E; Bellido, M; Verdaguer, X; de Pouplana, LR; Riera, A
BIOCONJUGATE CHEMISTRY
31
3
933 -
938
2020
P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis
Cabré, A; Riera, A; Verdaguer, X
ACCOUNTS OF CHEMICAL RESEARCH
53
3
676 -
689
2020
Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols
Cabre, A; Rafael, S; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
59
19
7521 -
7527
2020
From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy
Kennel, P; Dichamp, J; Barreau, C; Guissard, C; Teyssedre, L; Rouquette, J; Colombelli, J; Lorsignol, A; Casteilla, L; Plouraboué, F
PLoS Computational Biology
16
2
e1007322 -
2020
A multi-modal coarse grained model of DNA flexibility mappable to the atomistic level
Walther, J; Dans, PD; Balaceanu, A; Hospital, A; Bayarri, G; Orozco, M
NUCLEIC ACIDS RESEARCH
48
5
e29 -
2020
Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio, L; Milán, M
DEVELOPMENTAL CELL
52
5
659 -
2020
The mitochondrial tRNA conundrum
de Pouplana, LR
NATURE REVIEWS MOLECULAR CELL BIOLOGY
21
7
361 -
361
2020
The embryonic linker histone dBigH1 alters the functional state of active chromatin
Climent-Cantó, P; Carbonell, A; Tatarski, M; Reina, O; Bujosa, P; Font-Mateu, J; Bernués, J; Beato, M; Azorín, F
NUCLEIC ACIDS RESEARCH
48
8
4147 -
4160
2020
Requirement for epithelial p38α in KRAS-driven lung tumor progression
Vitos-Faleato, J; Real, SM; Gutierrez-Prat, N; Villanueva, A; Llonch, E; Drosten, M; Barbacid, M; Nebreda, AR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
117
5
2588 -
2596
2020
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
Marín-Aguilar F; Lechuga-Vieco AV
Aging Cell
2020
Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics
Lechuga-Vieco, AV
Sci. Adv
2020
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
Nicolás-Ávila, JA*; Lechuga-Vieco, AV*
Cell
2020
Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E
Nat Chem Bio
2020
Dendritic cells in cancer immunology and immunotherapy
Wculek SK*, Cueto FJ*, Mujal AM, Melero I, Krummel MF, Sancho D#
(#) Corresponding author; (*) these authors contributed equally
Nature Reviews Immunology
20(1):7-24
2020
Early neutrophil responses to chemical carcinogenesis shape long-term lung cancer susceptibility
Wculek SK*, Bridgeman VL*, Peakman F, Malanchi I#
(#) Corresponding author; (*) these authors contributed equally
iScience
23(7):101277
2020
Senolytic CAR T cells reverse senescence-associated pathologies
Amor C*, Feucht J*, Leibold J*, Ho Y-J, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, et al, Sadelain M, Lowe SW.
(*) these authors contributed equally
Nature
2020
An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants
Paz Zafra M, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Calvo Fernandez MT, Wilkinson JE, Piskounova E and Dow LE.
Cancer Discovery
2020
Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E
Nat Chem Bio
2020
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Alejo E Rodriguez-Fraticelli, Caleb S Weinreb, Shou Wen Wang, Rosa P Migueles, Maja Jankovic, Marc Usart, Allon M Klein, Sally Lowell, Fernando D Camargo
Nature
2020
Lineage tracing on transcriptional landscapes links state to fate during differentiation
Caleb S Weinreb(#), Alejo E Rodriguez-Fraticelli(#), Fernando D Camargo, Allon M Klein (# Equal contribution)
Science
2020
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Hernández-Alvarez, MI; Sebastián, D; Vives, S; Ivanova, S; Bartoccioni, P; Kakimoto, P; Plana, N; Veiga, SR; Hernández, V; Vasconcelos, N; Peddinti, G; Adrover, A; Jové, M; Pamplona, R; Gordaliza-Alaguero, I; Calvo, E; Cabré, N; Castro, R; Kuzmanic, A; Boutant, M; Sala, D; Hyotylainen, T; Oresic, M; Fort, J; Errasti-Murugarren, E;...
CELL
177
4
881 -
2019
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh, B; Banduseela, VC; Chiesa, G; Martínez-Cristóbal, P; Rauch, JN; Nath, SR; Schwarz, DMC; Shao, H; Marin-Argany, M; Di Sanza, C; Giorgetti, E; Yu, ZG; Pieratelli, R; Felli, IC; Brun-Heath, I; García, J; Nebreda, AR; Gestwicki, JE; Lieberman, AP; Salvatella, X
Nature Communications
10
1
3562 -
2019
The Expansion of Inosine at the Wobble Position of tRNAs, and Its Role in the Evolution of Proteomes
Rafels-Ybern, A; Torres, AG; Camacho, N; Herencia-Ropero, A; Frigolé, HR; Wulff, TF; Raboteg, M; Bordons, A; Grau-Bove, X; Ruiz-Trillo, I; de Pouplana, LR
MOLECULAR BIOLOGY AND EVOLUTION
36
4
650 -
662
2019
Evolutionary and functional patterns of shared gene neighbourhood in fungi
Marcet-Houben, M; Gabaldón, T
Nature Microbiology
4
12
2383 -
2392
2019
The mutational footprints of cancer therapies
Pich, O; Muiños, F; Lolkema, MP; Steeghs, N; Gonzalez-Perez, A; Lopez-Bigas, N
NATURE GENETICS
51
12
1732 -
2019
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Lindeboom, RGH; Vermeulen, M; Lehner, B; Supek, F
NATURE GENETICS
51
11
1645 -
2019
Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
Aragón, E; Wang, Q; Zou, YL; Morgani, SM; Ruiz, L; Kaczmarska, Z; Su, J; Torner, C; Tian, L; Hu, J; Shu, WP; Agrawal, S; Gomes, T; Márquez, JA; Hadjantonakis, AK; Macias, MJ; Massagué, J
GENES & DEVELOPMENT
33
21-22
1506 -
1524
2019
Inducible slc7a7 knockout mouse model recapitulates lysinuric protein intolerance disease
Bodoy, S; Sotillo, F; Espino-Guarch, M; Sperandeo, MP; Ormazabal, A; Zorzano, A; Sebastio, G; Artuch, R; Palacín, M
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
20
21
5294 -
2019
Cellular Senescence: Defining a Path Forward
Gorgoulis, V; Adams, PD; Alimonti, A; Bennett, DC; Bischof, O; Bishop, C; Campisi, J; Collado, M; Evangelou, K; Ferbeyre, G; Gil, J; Hara, E; Krizhanovsky, V; Jurk, D; Maier, AB; Narita, M; Niedernhofer, L; Passos, JF; Robbins, PD; Schmitt, CA; Sedivy, J; Vougas, K; von Zglinicki, T; Zhou, DH; Serrano, M; Demaria, M
CELL
179
4
813 -
827
2019
Atomic structure of the Epstein-Barr virus portal
Machón, C; Fàbrega-Ferrer, M; Zhou, DM; Cuervo, A; Carrascosa, JL; Stuart, DI; Coll, M
Nature Communications
10
1
3891 -
2019
Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
Cuervo, A; Fàbrega-Ferrer, M; Machón, C; Conesa, JJ; Fernández, FJ; Pérez-Luque, R; Pérez-Ruiz, M; Pous, J; Vega, MC; Carrascosa, JL; Coll, M
Nature Communications
10
1
3746 -
2019
The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila
Molnar, C; Heinen, JP; Reina, J; Llamazares, S; Palumbo, E; Breschi, A; Gay, M; Villarreal, L; Vilaseca, M; Pollarolo, G; Gonzalez, C
Science Advances
5
8
eaaw7965 -
2019
Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
Batlle, R; Andrés, E; Gonzalez, L; Llonch, E; Igea, A; Gutierrez-Prat, N; Berenguer-Llergo, A; Nebreda, AR
Nature Communications
10
1
3071 -
2019
The chemistry of senescence
Lozono-Torres, B; Estepa-Fernández, A; Rovira, M; Orzáez, M; Serrano, M; Martínez-Máñez, R; Sancenón, F
Nature Reviews Chemistry
3
7
426 -
441
2019
Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage
Murcia, L; Clemente-Ruiz, M; Pierre-Elies, P; Royou, A; Milán, M
Cell Reports
28
1
119 -
2019
An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases
Aranda, J; Terrazas, M; Gómez, H; Villegas, N; Orozco, M
Nature Catalysis
2
6
544 -
552
2019
Defining the Independence of the Liver Circadian Clock
Koronowski, KB; Kinouchi, K; Welz, PS; Smith, JG; Zinna, VM; Shi, JJ; Samad, M; Chen, SW; Magnan, CN; Kinchen, JM; Li, W; Baldi, P; Benitah, SA; Sassone-Corsi, P
CELL
177
6
1448 -
2019
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
Welz, PS; Zinna, VM; Symeonidi, A; Koronowski, KB; Kinouchi, K; Smith, JG; Guillén, IM; Castellanos, A; Crainiciuc, G; Prats, N; Caballero, JM; Hidalgo, A; Sassone-Corsi, P; Benitah, SA
CELL
177
6
1436 -
1447
2019
Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments
Torres, AG; Reina, O; Attolini, CSO; de Pouplana, LR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
116
17
8451 -
8456
2019
Lysosomal trapping of palbociclib and its functional implications
Llanos, S; Megias, D; Blanco-Aparicio, C; Hernández-Encinas, E; Rovira, M; Pietrocola, F; Serrano, M
ONCOGENE
38
20
3886 -
3902
2019
Highly Enantioselective Iridium-Catalyzed Hydrogenation of 2-Aryl Allyl Phthalimides
Cabré, A; Romagnoli, E; Martínez-Balart, P; Verdaguer, X; Riera, A
ORGANIC LETTERS
21
23
9709 -
9713
2019
CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression
Cano-Crespo, S; Chillarón, J; Junza, A; Fernández-Miranda, G; García, J; Polte, C; de la Ballina, LR; Ignatova, Z; Yanes, O; Zorzano, A; Attolini, CSO; Palacín, M
Scientific Reports
9
1
14065 -
2019
Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
Pittolo, S; Lee, H; Lladó, A; Tosi, S; Bosch, M; Bardia, L; Gómez-Santacana, X; Llebaria, A; Soriano, E; Colombelli, J; Poskanzer, KE; Perea, G; Gorostiza, P
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
116
27
13680 -
13689
2019
The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry
Terrazas, M; Genna, V; Portella, G; Villegas, N; Sánchez, D; Arnan, C; Pulido-Quetglas, C; Johnson, R; Guigó, R; Brun-Heath, I; Aviñó, A; Eritja, R; Orozco, M
Chem
5
6
1619 -
1631
2019
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Orellana, L; Thorne, AH; Lema, R; Gustavsson, J; Parisian, AD; Hospital, A; Cordeiro, TN; Bernadó, P; Scott, AM; Brun-Heath, I; Lindahl, E; Cavenee, WK; Furnari, FB; Orozco, M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
116
20
10009 -
10018
2019
Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
Terré, B; Lewis, M; Gil-Gómez, G; Han, ZY; Lu, H; Aguilera, M; Prats, N; Roy, S; Zhao, HT; Stracker, TH
DEVELOPMENT
146
8
dev162628 -
2019