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Investigación

A la vanguardia de la biomedicina

Publicaciones sobre Investigación

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo, A; Topal, B; Kunze, MBA; Aranda, J; Chiesa, G; Mungianu, D; Bernardo-Seisdedos, G; Eftekharzadeh, B; Gairí, M; Pierattelli, R; Felli, IC; Diercks, T; Millet, O; García, J; Orozco, M; Crehuet, R; Lindorff-Larsen, K; Salvatella, X
Nature Communications
10
1
2034 -
2019
The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle
Moreno-Moreno, O; Torras-Llort, M; Azorin, F
NUCLEIC ACIDS RESEARCH
47
7
3395 -
3406
2019
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Errasti-Murugarren, E; Fort, J; Bartoccioni, P; Díaz, L; Pardon, E; Carpena, X; Espino-Guarch, M; Zorzano, A; Ziegler, C; Steyaert, J; Fernández-Recio, J; Fita, I; Palacín, M
Nature Communications
10
1807 -
2019
Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7
Bartoccioni, P; Fort, J; Zorzano, A; Errasti-Murugarren, E; Palacín, M
JOURNAL OF GENERAL PHYSIOLOGY
151
4
505 -
517
2019
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E; Massagué, J
IMMUNITY
50
4
924 -
940
2019
Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit
Picchioni, D; Antolin-Fontes, A; Camacho, N; Schmitz, C; Pons-Pons, A; Rodríguez-Escribà, M; Machallekidou, A; Güler, MN; Siatra, P; Carretero-Junquera, M; Serrano, A; Hovde, SL; Knobel, PA; Novoa, EM; Solà-Vilarrubias, M; Kaguni, LS; Stracker, TH; de Pouplana, LR
Cell Reports
27
1
40 -
2019
An In-Depth Look at DNA Crystals through the Prism of Molecular Dynamics Simulations
Kuzmanic, A; Dans, PD; Orozco, M
Chem
5
3
649 -
663
2019
Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics
Colizzi, F; Hospital, A; Zivanovic, S; Orozco, M
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
58
12
3759 -
3763
2019
Modeling, Simulations, and Bioinformatics at the Service of RNA Structure
Dans, PD; Gallego, D; Balaceanu, A; Darré, L; Gomez, H; Orozco, M
Chem
5
1
51 -
73
2019
Regulation of death receptor signaling by the autophagy protein TP53INP2
Ivanova, S; Polajnar, M; Narbona-Perez, AJ; Hernandez-Alvarez, MI; Frager, P; Slobodnyuk, K; Plana, N; Nebreda, AR; Palacin, M; Gomis, RR; Behrends, C; Zorzano, A
EMBO JOURNAL
38
10
e99300 -
2019
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy
Latorre-Pellicer, A*; Lechuga-Vieco AV*
Cell Metab
2019
Metabolic control of dendritic cell functions: digesting information
Wculek SK#, Khouili SC, Priego E, Heras-Murillo I, Sancho D#
(#) Corresponding author
Frontiers in Immunology
10:775
2019
Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen
Wculek SK, Amores-Iniesta J, Conde-Garrosa R, Khouili SC, Melero I, Sancho D#
(#) Corresponding author
Journal for ImmunoTherapy of Cancer
7(1):100
2019
Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancer
Osmanbeyoglu HU, Shimizu F*, Rynne-Vidal A*, Alonso-Curbelo D*, Chen HA, Wen HY, Yeung TL, Jelinic P, Razavi P, Lowe SW, Mok SC, Chiosis G, Levine DA, Leslie CS.
(*) these authors contributed equally
Nature Communications
2019
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
Mayor-Ruiz, C.1,*, Jaeger, M.G*, Bauer, S., Brand, M., Sin, C., Hanzl, A., Mueller, A.C., Menche, J., and Winter, G.E.1
1 co-corresponding; *Co-first authors
Molecular Cell
75
849 -
858
2019
Identification and characterization of cancer vulnerabilities via targeted protein degradation
Mayor-Ruiz, C., and Winter, G.E
Drug Discov Today Technol
31
81 -
90
2019
Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours
Avgustinova, A; Symeonidi, A; Castellanos, A; Urdiroz-Urricelqui, U; Sole-Boldo, L; Martin, M; Perez-Rodriguez, I; Prats, N; Lehner, B; Supek, F; Benitah, SA
NATURE CELL BIOLOGY
20
12
1400 -
2018
Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
Rodríguez-Nuevo, A; Díaz-Ramos, A; Noguera, E; Díaz-Sáez, F; Duran, X; Muñoz, JP; Romero, M; Plana, N; Sebastián, D; Tezze, C; Romanello, V; Ribas, F; Seco, J; Planet, E; Doctrow, SR; González, J; Borràs, M; Liesa, M; Palacín, M; Vendrell, J; Villarroya, F; Sandri, M; Shirihai, O; Zorzano, A
EMBO JOURNAL
37
10
e96553 -
2018
Senescence promotes invivo reprogramming through p16(INK4a) and IL-6
Mosteiro, L; Pantoja, C; de Martino, A; Serrano, M
AGING CELL
17
2
e12711 -
2018
Targeting senescence
Serrano, M; Barzilai, N
NATURE MEDICINE
24
8
1092 -
1094
2018
AAVvector-mediated in vivo reprogramming into pluripotency
Senís, E; Mosteiro, L; Wilkening, S; Wiedtke, E; Nowrouzi, A; Afzal, S; Fronza, R; Landerer, H; Abad, M; Niopek, D; Schmidt, M; Serrano, M; Grimm, D
Nature Communications
9
1
2651 -
2018
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
Salzer, MC; Lafzi, A; Berenguer-Llergo, A; Youssif, C; Castellanos, A; Solanas, G; Peixoto, FO; Attolini, CSO; Prats, N; Aguilera, M; Martín-Caballero, J; Heyn, H; Benitah, SA
CELL
175
6
1575 -
2018
Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst
Salomó, E; Gallen, A; Sciortino, G; Ujaque, G; Grabulosa, A; Lledós, A; Riera, A; Verdaguer, X
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
140
49
16967 -
16970
2018
Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues
Benhra, N; Barrio, L; Muzzopappa, M; Milán, M
DEVELOPMENTAL CELL
47
2
161 -
2018
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
Bouchard, JJ; Otero, JH; Scott, DC; Szulc, E; Martin, EW; Sabri, N; Granata, D; Marzahn, MR; Lindorff-Larsen, K; Salvatella, X; Schulman, BA; Mittag, T
MOLECULAR CELL
72
1
19 -
2018
Centrobin is essential for c-tubule assembly and flagellum development in drosophila melanogaster spermatogenesis
Reina, J; Gottardo, M; Riparbelli, MG; Llamazares, S; Callaini, G; Gonzalez, C
JOURNAL OF CELL BIOLOGY
217
7
2365 -
2372
2018
Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
Youssif, C; Cubillos-Rojas, M; Comalada, M; Llonch, E; Perna, C; Djouder, N; Nebreda, AR
EMBO Molecular Medicine
10
7
e8403 -
2018
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β
Romero, M; Sabaté-Pérez, A; Francis, VA; Castrillón-Rodriguez, I; Díaz-Ramos, A; Sánchez-Feutrie, M; Durán, X; Palacín, M; Moreno-Navarrete, JM; Gustafson, B; Hammarstedt, A; Fernández-Real, JM; Vendrell, J; Smith, U; Zorzano, A
NATURE CELL BIOLOGY
20
4
443 -
2018
Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth
Campbell, K; Lebreton, G; Franch-Marro, X; Casanova, J
PLoS Genetics
14
2
1007167 -
2018
Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism
Miret-Casals, L; Sebastían, D; Brea, J; Rico-Leo, EM; Palacín, M; Fernández-Salguero, PM; Loza, MI; Albericio, F; Zorzano, A
Cell Chemical Biology
25
3
268 -
2018
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
Duch A; Canal B; Barroso S; García-Rubio M; Seisenbacher G; Aguilera A; De Nadal E; Posas F
Nature Communications
9
1
379 -
2018
Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators
De Mol, E; Szulc, E; Di Sanza, C; Martínez-Cristóbal, P; Bertoncini, CW; Fenwick, RB; Frigolé-Vivas, M; Masín, M; Hunter, I; Buzón, V; Brun-Heath, I; García, J; De Fabritiis, G; Estébanez-Perpiña, E; McEwan, IJ; Nebreda, AR; Salvatella, X
STRUCTURE
26
1
145 -
2018
Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines
Cabré, A; Sciortino, G; Ujaque, G; Verdaguer, X; Lledós, A; Riera, A
ORGANIC LETTERS
20
18
5747 -
5751
2018
A versatile drug delivery system targeting senescent cells
Muñoz-Espín, D; Rovira, M; Galiana, I; Giménez, C; Lozano-Torres, B; Paez-Ribes, M; Llanos, S; Chaib, S; Muñoz-Martín, M; Ucero, AC; Garaulet, G; Mulero, F; Dann, SG; VanArsdale, T; Shields, DJ; Bernardos, A; Murguía, JR; Martínez-Máñez, R; Serrano, M
EMBO Molecular Medicine
10
9
e9355 -
2018
Total Synthesis of ( R)-Sarkomycin Methyl Ester via Regioselective Intermolecular Pauson-Khand Reaction and Iridium-Catalyzed Asymmetric Isomerization.
Cabré, A; Khaizourane, H; Garçon, M; Verdaguer, X; Riera, A
ORGANIC LETTERS
20
13
3953 -
3957
2018
Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing
Parras, A; Anta, H; Santos-Galindo, M; Swarup, V; Elorza, A; Nieto-González, JL; Picó, S; Hernández, IH; Díaz-Hernández, JI; Belloc, E; Rodolosse, A; Parikshak, NN; Peñagarikano, O; Fernández-Chacón, R; Irimia, M; Navarro, P; Geschwind, DH; Méndez, R; Lucas, JJ
NATURE
560
7719
441 -
2018
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Tauriello, DVF; Palomo-Ponce, S; Stork, D; Berenguer-Llergo, A; Badia-Ramentol, J; Iglesias, M; Sevillano, M; Ibiza, S; Cañellas, A; Momblona, XH; Byrom, D; Matarin, JA; Calon, A; Rivas, EI; Nebreda, AR; Riera, A; Attolini, CSO; Batlle, E
NATURE
554
7693
538 -
2018
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
Cánovas, B; Igea, A; Sartori, AA; Gomis, RR; Paull, TT; Isoda, M; Pérez-Montoyo, H; Serra, V; González-Suárez, E; Stracker, TH; Nebreda, AR
CANCER CELL
33
6
1094 -
2018
The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity
Lynch, CJ; Bernad, R; Calvo, I; Nóbrega-Pereira, S; Ruiz, S; Ibarz, N; Martinez-Val, A; Graña-Castro, O; Gómez-López, G; Andrés-León, E; Angarica, VE; del Sol, A; Ortega, S; Fernandez-Capetillo, O; Rojo, E; Munoz, J; Serrano, M
Cell Reports
22
2
396 -
410
2018
Cooperation of Antiporter LAT2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids.
Vilches, C; Boiadjieva-Knöpfel, E; Bodoy, S; Camargo, S; de Heredia, ML; Prat, E; Ormazabal, A; Artuch, R; Zorzano, A; Verrey, F; Nunes, V; Palacín, M
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
29
6
1624 -
1635
2018
Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss.
Guarch, ME; Font-Llitjós, M; Murillo-Cuesta, S; Errasti-Murugarren, E; Celaya, AM; Girotto, G; Vuckovic, D; Mezzavilla, M; Vilches, C; Bodoy, S; Sahún, I; González, L; Prat, E; Zorzano, A; Dierssen, M; Varela-Nieto, I; Gasparini, P; Palacín, M; Nunes, V
eLife
7
e31511 -
2018
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+breast cancer
Gawrzak, S; Rinaldi, L; Gregorio, S; Arenas, EJ; Salvador, F; Urosevic, J; Figueras-Puig, C; Rojo, F; Barrantes, ID; Cejalvo, JM; Palafox, M; Guiu, M; Berenguer-Llergo, A; Symeonidi, A; Bellmunt, A; Kalafatovic, D; Arnal-Estapé, A; Fernández, E; Müllauer, B; Groeneveld, R; Slobodnyuk, K; Attolini, CSO; Saura, C; Arribas, J; Cortes, J; Rovira,...
NATURE CELL BIOLOGY
20
2
211 -
2018
Ablation of the stress protease OMA1 protects against heart failure in mice
Acin-Perez R; Lechuga-Vieco AV
Sci. Transl
2018
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity
Finley LWS*, Vardhana SA*, Carey BW*, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, et al, [corr author] Thompson CB.
(*) these authors contributed equally
Nature Cell Biology
2018
Arid1a restrains Kras-dependent changes in acinar cell identity
Livshits D, Alonso-Curbelo D, Morris JP4th, Koche R, Saborowski M, Wilkinson JE, Lowe SW
eLife
2018
ERF deletion rescues RAS deficiency in mouse ES cells
Mayor-Ruiz C., Olbrich T., Drosten M., Lecona E., Vega-Sendino M., Ortega S., Dominguez O., Barbacid M., Ruiz S. & Fernandez-Capetillo O
Genes & Dev
32
568 -
576
2018
Clonal analysis of lineage fate in native haematopoiesis
Alejo E Rodriguez-Fraticelli, Samuel L Wolock, Caleb S Weinreb, Riccardo Panero, Sachin H Patel, Maja Jankovic, Jianlong Sun, Raffaele A Calogero, Allon M Klein, Fernando D Camargo
Nature
2018
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas, G; Peixoto, FO; Perdiguero, E; Jardí, M; Ruiz-Bonilla, V; Datta, D; Symeonidi, A; Castellanos, A; Welz, PS; Caballero, JM; Sassone-Corsi, P; Muñoz-Cánoves, P; Benitah, SA
CELL
170
4
678 -
2017