Publicaciones sobre Investigación

Title

Year

Research Group

Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

Sato, S; Solanas, G; Peixoto, FO; Bee, L; Symeonidi, A; Schmidt, MS; Brenner, C; Masri, S; Benitah, SA; Sassone-Corsi, P

CELL

170

664 -

2017

Loss of dnmt3a and dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-g

Rinaldi, L; Avgustinova, A; Martín, M; Datta, D; Solanas, G; Prats, N; Benitah, SA

eLife

e21697 -

2017

An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth

Rossi, F; Molnar, C; Hashiyama, K; Heinen, JP; Pampalona, J; Llamazares, S; Reina, J; Hashiyama, T; Rai, M; Pollarolo, G; Fernández-Hernández, I; Gonzalez, C

Open Biology

170156 -

2017

The Germline Linker Histone dBigH1 and the Translational Regulator Bam Form a Repressor Loop Essential for Male Germ Stem Cell Differentiation

Carbonell, A; Pérez-Montero, S; Climent-Cantó, P; Reina, O; Azorín, F

Cell Reports

3178 -

3189

2017

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Martin-Malpartida, P; Batet, M; Kaczmarska, Z; Freier, R; Gomes, T; Aragón, E; Zou, YL; Wang, Q; Xi, QR; Ruiz, L; Vea, A; Márquez, JA; Massagué, J; Macias, MJ

Nature Communications

2070 -

2017

Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial

Coleman, R; Hall, A; Albanell, J; Hanby, A; Bell, R; Cameron, D; Dodwell, D; Marshall, H; Jean-Mairet, J; Tercero, JC; Rojo, F; Gregory, W; Gomis, RR

LANCET ONCOLOGY

1543 -

1552

2017

Cancer stem cells revisited

Batlle, E; Clevers, H

NATURE MEDICINE

1124 -

1134

2017

Differential requirements for Tousled-like kinases 1 and 2 in mammalian development

Segura-Bayona, S; Knobel, PA; González-Burón, H; Youssef, SA; Peña-Blanco, A; Coyaud, É; López-Rovira, T; Rein, K; Palenzuela, L; Colombelli, J; Forrow, S; Raught, B; Groth, A; de Bruin, A; Stracker, TH

CELL DEATH AND DIFFERENTIATION

1872 -

1885

2017

Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing

Barrio, L; Milán, M

eLife

e22013 -

2017

Feedback amplification loop drives malignant growth in epithelial tissues

Muzzopappa, M; Murcia, L; Milán, M

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

114

E7291 -

E7300

2017

Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

Bayona-Feliu, A; Casas-Lamesa, A; Reina, O; Bernués, J; Azorín, F

Nature Communications

283 -

2017

Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs

Weill, L; Belloc, E; Castellazzi, CL; Méndez, R

NATURE STRUCTURAL & MOLECULAR BIOLOGY

672 -

2017

Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment

Testoni, G; Duran, J; García-Rocha, M; Vilaplana, F; Serrano, AL; Sebastián, D; López-Soldado, I; Sullivan, MA; Slebe, F; Vilaseca, M; Muñoz-Cánoves, P; Guinovart, JJ

Cell Metabolism

256 -

2017

A genome editing approach to study cancer stem cells in human tumors

Cortina, C; Turon, G; Stork, D; Hernando-Momblona, X; Sevillano, M; Aguilera, M; Tosi, S; Merlos-Suárez, A; Attolini, CSO; Sancho, E; Batlle, E

EMBO Molecular Medicine

869 -

879

2017

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

Barriga, FM; Montagni, E; Mana, M; Mendez-Lago, M; Hernando-Momblona, X; Sevillano, M; Guillaumet-Adkins, A; Rodriguez-Esteban, G; Buczacki, SJA; Gut, M; Heyn, H; Winton, DJ; Yilmaz, OH; Attolini, CSO; Gut, I; Batlle, E

Cell Stem Cell

801 -

2017

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

Recasens-Alvarez, C; Ferreira, A; Milán, M

Nature Communications

13815 -

2017

Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance

Pluta, R; Boer, DR; Lorenzo-Díaz, F; Russi, S; Gómez, H; Fernández-López, C; Pérez-Luque, R; Orozco, M; Espinosa, M; Coll, M

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

114

E6526 -

E6535

2017

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Ramírez, S; Gómez-Valadés, AG; Schneeberger, M; Varela, L; Haddad-Tóvolli, R; Altirriba, J; Noguera, E; Drougard, A; Flores-Martínez, A; Imbernón, M; Chivite, I; Pozo, M; Vidal-Itriago, A; Garcia, A; Cervantes, S; Gasa, R; Nogueiras, R; Gama-Pérez, P; Garcia-Roves, PM; Cano, DA; Knauf, C; Servitja, JM; Horvath, TL; Gomis, R; Zorzano, A;...

Cell Metabolism

1390 -

2017

Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress

Maillo, C; Martín, J; Sebastián, D; Hernández-Alvarez, M; García-Rocha, M; Reina, O; Zorzano, A; Fernandez, M; Méndez, R

NATURE CELL BIOLOGY

94 -

105

2017

Targeting metastasis-initiating cells through the fatty acid receptor CD36.

Pascual, G; Avgustinova, A; Mejetta, S; Martín, M; Castellanos, A; Attolini, CSO; Berenguer, A; Prats, N; Toll, A; Hueto, JA; Bescós, C; Di Croce, L; Benitah, SA

NATURE

541

7635

41 -

2017

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T., Mayor-Ruiz C., Vega-Sendino M., Gomez C., Ortega S., Ruiz S. & Fernandez-Capetillo O.

PNAS

114

9367 -

9372

2017

TrapSeq: An RNA sequencing-based pipeline for the identification of genetrap insertions in mammalian cells

Mayor-Ruiz C., Dominguez O., Fernandez-Capetillo O

J Mol Bio

429

2780 -

2789

2017

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

Slebe, F; Rojo, F; Vinaixa, M; García-Rocha, M; Testoni, G; Guiu, M; Planet, E; Samino, S; Arenas, EJ; Beltran, A; Rovira, A; Lluch, A; Salvatella, X; Yanes, O; Albanell, J; Guinovart, JJ; Gomis, RR

Nature Communications

11199 -

2016

Epigenetic control of adult stem cell function

Avgustinova, A; Benitah, SA

NATURE REVIEWS MOLECULAR CELL BIOLOGY

643 -

658

2016

CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

Guillén-Boixet, J; Buzon, V; Salvatella, X; Méndez, R

eLife

e19298 -

2016

Amino acid transport associated to cluster of differentiation 98 heavy chain (CD98HC) is at the cross-road of oxidative stress and amino acid availability

de la Ballina, LR; Cano-Crespo, S; González-Muñoz, E; Bial, S; Estrach, S; Cailleteau, L; Tissot, F; Daniel, H; Zorzano, A; Ginsberg, MH; Palacín, M; Féral, CC

JOURNAL OF BIOLOGICAL CHEMISTRY

291

9700 -

9711

2016

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells

Gubern A; Joaquin M; Marquès M; Maseres P; Garcia-Garcia J; Amat R; González-Nuñez D; Oliva B; Real F; de Nadal E; Posas F

MOLECULAR CELL

25 -

2016

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Becker, D; Kaczmarska, Z; Arkona, C; Schulz, R; Tauber, C; Wolber, G; Hilgenfeld, R; Coll, M; Rademann, J

Nature Communications

12761 -

2016

Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

Sebastián, D; Sorianello, E; Segalés, J; Irazoki, A; Ruiz-Bonilla, V; Sala, D; Planet, E; Berenguer-Llergo, A; Muñoz, JP; Sánchez-Feutrie, M; Plana, N; Hernández-Alvarez, MI; Serrano, AL; Palacín, M; Zorzano, A

EMBO JOURNAL

1677 -

1693

2016

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

Sánchez-Huertas, C; Freixo, F; Viais, R; Lacasa, C; Soriano, E; Lüders, J

Nature Communications

12187 -

2016

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Eftekharzadeh, B; Piai, A; Chiesa, G; Mungianu, D; García, J; Pierattelli, R; Felli, IC; Salvatella, X

BIOPHYSICAL JOURNAL

110

2361 -

2366

2016

Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea

Djabrayan, NJV; Casanova, J

PLoS Genetics

e1005909 -

2016

A feedback mechanism converts individual cell features into a supracellular ECM structure in drosophila trachea

Öztürk-Çolak, A; Moussian, B; Araújo, SJ; Casanova, J

eLife

e09373 -

2016

GEMC1 is a critical regulator of multiciliated cell differentiation

Terré, B; Piergiovanni, G; Segura-Bayona, S; Gil-Gómez, G; Youssef, SA; Attolini, CSO; Wilsch-Bräuninger, M; Jung, C; Rojas, AM; Marjanovic, M; Knobel, PA; Palenzuela, L; López-Rovira, T; Forrow, S; Huttner, WB; Valverde, MA; de Bruin, A; Costanzo, V; Stracker, TH

EMBO JOURNAL

942 -

960

2016

Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis

Clemente-Ruiz, M; Murillo-Maldonado, JM; Benhra, N; Barrio, L; Pérez, L; Quiroga, G; Nebreda, AR; Milán, M

DEVELOPMENTAL CELL

290 -

302

2016

Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry

Pittis, AA; Gabaldón, T

NATURE

531

7592

101 -

2016

Saturation of recognition elements blocks evolution of new tRNA identities

Saint-Léger, A; Bello, C; Dans, PD; Torres, AG; Novoa, EM; Camacho, N; Orozco, M; Kondrashov, FA; de Pouplana, LR

Science Advances

e1501860 -

2016

Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides

Salomó, E; Orgué, S; Riera, A; Verdaguer, X

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

7988 -

7992

2016

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

De Mol, E; Fenwick, RB; Phang, CTW; Buzón, V; Szulc, E; de la Fuente, A; Escobedo, A; García, J; Bertoncini, CW; Estébanez-Perpiñá, E; McEwan, IJ; Riera, A; Salvatella, X

ACS Chemical Biology

2499 -

2505

2016

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

Nagamori, S; Wiriyasermkul, P; Guarch, ME; Okuyama, H; Nakagomi, S; Tadagaki, K; Nishinaka, Y; Bodoy, S; Takafuji, K; Okuda, S; Kurokawa, J; Ohgaki, R; Nunes, V; Palacin, M; Kanai, Y

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

113

775 -

780

2016

Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope

Mikolcevic, P; Isoda, M; Shibuya, H; Barrantes, ID; Igea, A; Suja, JA; Shackleton, S; Watanabe, Y; Nebreda, AR

Nature Communications

11084 -

2016

Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease

Calderone, V; Gallego, J; Fernandez-Miranda, G; Garcia-Pras, E; Maillo, C; Berzigotti, A; Mejias, M; Bava, FA; Angulo-Urarte, A; Graupera, M; Navarro, P; Bosch, J; Fernandez, M; Mendez, R

GASTROENTEROLOGY

150

982 -

2016

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

Latorre-Pellicer A; Moreno-Loshuertos R; Lechuga-Vieco, AV

Nature

2016

BRD4 connects super enhancer remodeling to senescence immune surveillance

Tasdemir N*, Banito B*, Roe JS*, Alonso-Curbelo D*, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CV, Lowe SW.
(*) these authors contributed equally

Cancer Discovery

2016

A genome- wide CRISPR screen identifies Cdc25A as a determinant of sensitivity to ATR inhibitors

Ruiz S. (#), Mayor-Ruiz C. (#), Lafarga V., Murga M., Vega-Sendino M., Ortega S., Fernandez-Capetillo O. ( # Equal contribution)

Mol Cell

307 -

313

2016

Designing alternative splicing RNA-seq studies. Beyond generic guidelines

Attolini, CSO; Peña, V; Rossell, D

BIOINFORMATICS

3631 -