Chemistry and Molecular PharmacologyLaboratory of Molecular Biophysics

Laboratory of Molecular Biophysics

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Fenwick RB, Orellana L, Esteban-Martín S, Orozco M and Salvatella X.
Nat Commun, 5 4070 (2014)
Candotti M, Esteban-Martín S, Salvatella X and Orozco M.
P Natl Acad Sci Usa, 110 (15), 5933-8 (2013)
Fenwick RB, Esteban-Martín S, Richter B, Lee D, Walter KF, Milovanovic D, Becker S, Lakomek NA, Griesinger C and Salvatella X.
J Am Chem Soc, 133 (27), 10336-9 (2011)
Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM and Salvatella X.
Angew Chem Int Edit, 50 (31), 7048-51 (2011)
Esteban-Martín S, Fenwick RB and Salvatella X.
J Am Chem Soc, 132 (13), 4626-32 (2010)
Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM and Salvatella X.
J Mol Biol, 402 (5), 783-96 (2010)

Group news & mentions

13 Mar 2015

The business section of “La Vanguardia”, in addition to other media and organizations, have highlighted the Consolidator Grant awarded by the European Research Council (ERC) to the project

12 Mar 2015

The European Research Council (ERC) has awarded a Consolidator Grant to ICREA researcher Xavier Salvatella, head of the Molecular Biophysics Lab

5 Mar 2015

On Friday 6 March at 19h in “Centre de Cultura Contemporània de Barcelona” (CCCB), Xavier Salvatella, ICREA resea

12 Jun 2014

Genetic Engineering & Biotechnology News (GEN) devotes a news item to the recent study by IRB Barcelona scientists Xavier Salvatella and Modesto Orozco

Upcoming events

08 Jul

Speaker: Manuel Irimia, CRG, Barcelona, Spain

09 Jul

Speaker: Silvia Vilaprinyó, Design, synthesis and structure of peptides and proteins, IRB Barcelona

 

10 Jul

Speaker: Rick Millane, Department of Electrical and Computer Engineering, University of Canterbury, Christchurch, New Zealand

 

10 Jul

Speaker: Dr. Jacques Pouysségur, Institute for Research on Cancer and Aging, Nice (IRCAN) - University of Nice, CNRS, Inserm, Centre A. Lacassagne