Chemistry and Molecular PharmacologyLaboratory of Molecular Biophysics

Laboratory of Molecular Biophysics

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Fenwick RB, Orellana L, Esteban-Martín S, Orozco M and Salvatella X.
Nat Commun (5), 4070 (2014)
Candotti M, Esteban-Martín S, Salvatella X and Orozco M.
Proc Natl Acad Sci U S A, 15 (110), 5933-8 (2013)
Fenwick RB, Esteban-Martín S, Richter B, Lee D, Walter KF, Milovanovic D, Becker S, Lakomek NA, Griesinger C and Salvatella X.
J Am Chem Soc, 27 (133), 10336-9 (2011)
Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM and Salvatella X.
Angew Chem Int Edit, 31 (50), 7048-51 (2011)
Esteban-Martín S, Fenwick RB and Salvatella X.
J Am Chem Soc, 13 (132), 4626-32 (2010)
Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM and Salvatella X.
J Mol Biol, 5 (402), 783-96 (2010)

Group news & mentions

12 Jun 2014

Genetic Engineering & Biotechnology News (GEN) devotes a news item to the recent study by IRB Barcelona scientists Xavier Salvatella and Modesto Orozco

12 Jun 2014

Proteins are chains of amino acids that, when folded into certain structural patterns and also when unfolded, exert functions within cells.

27 May 2014

A study published today in EMBO Molecular Medicine reveals that the loss of function of the gene RARRES3 in breast cancer cells promotes metastasis to the lung.

Upcoming events

25 Sep

Speaker: Dr. Laura Spagnolo,
University of Edinburgh, School of Biological Sciences, Institute of Structural Molecular Biology, UK

25 Sep

Speaker: Dr. Israel Sanchez,
MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, UK

25 Sep

Speaker: Riccardo Fodde,
PhD, Dept. of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands