Cancers evolve through deterministic genetic and epigenetic events as well as intricate interactions with the tissue microenvironment and host physiopathology. The complexity of these processes has precluded a comprehensive and integrated understanding of the key cancer cell-intrinsic and extrinsic events that enable cancer initiation, progression, and treatment resistance. Contemporary studies enabled by new experimental technologies, computational approaches, sophisticated model systems, and innovative clinical studies have begun to deconvolute this complexity. This new, exciting era in cancer biology is opening new opportunities to understand, predict and intercept the evolution of tumors.
This 40th edition of Biomed conference will provide an interdisciplinary forum for researchers interested in the principles that define and dictate malignant cell fates and the contexts in which these emerge and evolve. The conference will also showcase novel technologies to study cancer cell-intrinsic and extrinsic determinants of tumor evolution (eg. multidimensional profiling, AI, genome engineering, and spatial biology), and emerging concepts for clinical translation.
Topics
• From mechanism to phenotype: emerging concepts and technologies
• Evolutionary trajectories in premalignancy and cancer
• Crosstalk within normal and malignant ecosystems
• Cellular origins and hallmarks of neoplastic identity
• Challenges and opportunities for clinical translation
Presentation
Conference organizers
Dr. Direna Alonso-Curbelo
IRB Barcelona
Barcelona, Spain
Dr. Tuomas Tammela
MSKCC
New York, NY, USA
There is no registration fee for this conference, but the number of participants is limited, with a number of seats saved for IRB Barcelona alumni. Previous registration is required.
Due to the high demand for participation in this conference, the registration deadline has been brought forward on October 1st.
Priority will be given to those who submit the highest quality abstracts for short talks or posters and the order of registration will be considered. We will contact all those registered very soon.
Abstracts should include a title, authors, affiliations, summary (max 250 words) and references
REGISTRATION DEADLINE: OCTOBER 1st, 2023
(Note: Any issue about the registration or abstract, please contact: meritxell.gavalda@irbbarcelona.org)
Programme
Monday, 27 Nov
8.30 Registration
9.00 Welcome by Directorate of IRB Barcelona and organizers
(Dr. Direna Alonso-Curbelo and Dr. Tuomas Tammela)
Session 1: From mechanism to phenotype: emerging concepts and technologies
Chair:
9.15 What makes a cell competent to cause cancer?
Dr. Richard White, Ludwig Institute for Cancer Research (Oxford, UK)
9.50 Epigenetic influence of fatty acid metabolism on metastasis: consequences on cachexia
Dr. Salvador Aznar Benitah, IRB Barcelona/ ICREA (Barcelona, Spain)
10.25 Short talk 1
10.40-11.15 Coffee break and poster session
11.15 Modulation of 3D chromatin structures to support tumor evolution
Dr. Elisa Oricchio, EPFL (Lausanne, Switzerland)
11.50 Short talk 2
12.05 Short talk 3
12.20 Title to be confirmed
Dr. Tyler Jacks, Koch Institute for Integrative Cancer Research at MIT (Cambridge, MA, USA)
12.55-14.00 Lunch and poster session
Session 2: Evolutionary trajectories in premalignancy and cancer
Chair:
14.00 Title to be confirmed
Dr. Iñigo Martincorena, Wellcome Sanger Institute (Cambridge, UK)
14.35 Neoplastic co-option of cell and tissue plasticity in pancreatic tumorigenesis
Dr. Direna Alonso-Curbelo, IRB Barcelona (Barcelona, Spain)
15.10 Evolutionary trajectories from premalignancy to cancer: lessons from the oesophagus
Rebecca C. Fitzgerald, early Cancer Institute, University of Cambridge
15.45-16.15 Coffee break and poster session
16.15 Life history of breast cancer and related clones
Dr. Seishi Ogawa, Kyoto University (Kyoto, Japan)
16.50 Title to be confirmed
Dr. Mike Stratton, Wellcome Sanger Institute (Hinxton, UK)
17.25 Panel Discussion/Colloquium
18.00 End of session
Tuesday, 28 Nov
Session 3: Cellular origins and hallmarks of neoplastic identity
Chair:
9.00 Altering chromatin accessibility – implications for development and tumourigenesis
Dr. Alexandra Avgustinova, Institut de Recerca Sant Joan de Déu (Barcelona, Spain)
9.35 Title to be confirmed
Dr. Eduard Batlle, IRB Barcelona/ICREA (Barcelona, Spain)
10.10-10.40 Coffee break and poster session
10.40 Impact of aging on lung plasticity and tumorigenesis
Dr. Tuomas Tammela, Memorial Sloan Kettering Cancer Center (New York, USA)
11.15 Short talk 4
11.30 Short talk 5
11.45 EMT and cell plasticity trajectories in cancer progression
Dr. Ángela Nieto, Institute of Neurosciences of Alicante- UMH (Elche, Alicante)
12.30-13.20 Lunch and poster session
Session 4: Crosstalk within normal and malignant ecosystems
Chair:
13.20 Resolving site-specific immune barriers to metastasis
Dr. Ana Luisa Correia, Champalimaud Foundation (Lisboa, Portugal)
13.55 Single-cell spatial landscapes of the lung and brain tumour immune microenvironment
Dr. Logan Walsh, McGill University (Montreal, Quebec, Canada)
14.30 Short talk 6
14.45 Organoid cellular cancer immunity models in motion
Dr. Anne Rios, Princess Máxima Center for Pediatric Oncology (Utrecht, The Netherlands)
15.20-16.00 Coffee break and poster session
16.00 Malignant networks in brain tumors (and how to disconnect them)
Dr. Frank Winkler, DKFZ Heidelberg (Heidelberg, Germany)
16.35 Short talk 7
16.50 Select microbial responses by intestinal epithelial cells promotes repair and cancer
Dr. Gretchen Diehl, Memorial Sloan Kettering Cancer Center (New York, USA)
17.25 The power of ONE: Immunology in the age of single cell genomics
Dr. Ido Amit, Weizmann Institute of Science (Rehovot, Israel)
18.00 End of session
20.30 Speakers dinner (Restaurant Can Pineda) (Sant Joan de Malta, 55)
Wednesday, 29 Nov
Session 5: Challenges and opportunities for clinical translation
Chair:
9.00 Title to be confirmed
Dr. Luis Diaz, Memorial Sloan Kettering Cancer Center (New York, NY, USA)
9.35 Title to be confirmed
Dr. Samra Turajlic, The Francis Crick Institute (London, UK)
10.10 Short talk 8
10.25 Short talk 9
10.40-11.20 Coffee break and poster session
11.20 Somatic mutations in tumors and normal tissues
Dr. Núria López-Bigas, IRB Barcelona/ ICREA (Barcelona, Spain)
11.55 Short talk 10
12.10 Short talk 11
12.25 Title to be confirmed
Dr. Christina Curtis, Stanford University School of Medicine (Stanford, CA, USA)
13.00 Concluding remarks and end of conference
Venue
The BARCELONA BIOMED CONFERENCE CANCER IN CONTEXT: cellular, tissue, and organismal determinants of malignant fates will be placed at the Casa Convalescència in the heart of Barcelona. Talks will take place in the Aula Magna.
Casa Convalescència
C/ Sant Antoni Maria Claret, 171
08041 Barcelona
Tel +34 934 335 000
www.uab-casaconvalescencia.org
How to reach the Casa Convalescència:
Underground
Yellow line (L4) - GUINARDÓ – HOSPITAL DE SANT PAU station
Blue line (L5) - SANT PAU – DOS DE MAIG station
By bus
Lines: 15, 19, 20, 45, 47, 50, 51, 92 and 192.
For the GPS
Introduce the following coordinates:
Latitude: 41.413702 (41° 24' 49.33'' N)
Longitude: 2.177482 (2° 10' 38.94'' E)
From the airport
* Train + Underground. At the RENFE station, take the train to Sants-Estació. Once there take the Underground's blue line (L5) till SANT PAU – DOS DE MAIG station.
* Bus + Underground. Outside the airport terminal, take the AEROBUS to Plaça Catalunya. Walk one corner till Plaça Urquinaona and take the Underground's yellow line (L4) to GUINARDÓ – HOSPITAL DE SANT PAU station.
Barcelona Metropolitan Transport webiste (with metro and bus maps)
Accomodation
Speakers will be lodged at the Hotel Catalonia Sagrada Familia
Aragó 577- 579
08026, Barcelona
Telephone: +34 93 245 89 05
www.cataloniahotels.com/en/
Other hotels
A list of additional hotels within walking distance of the Casa Convalescència can be found at: https://www.barcelona-tourist-guide.com/en/hotels/hotelmaps/eixample-right-barcelona-hotel.html
(The Casa Convalescència is located near the violet point 27/3 star). Rates will vary depending on choice of hotel and season. Please check with the hotel of your choice directly for the best offer.
Residences
Another possibility is the Lesseps Residence Hall, and is available for short-term stays.
Lesseps Residence Hall
Plaza Lesseps, 12 08023 Barcelona
View on map
Telephone: +34 933 941 600
e-mail: lesseps@resa.es
www.resa.es/en/city/barcelona
Participants registered for events in the Barcelona BioMed series should contact the hotels and residences directly to arrange bookings and payment.
Speakers
Dr. Ido Amit
Weizmann Institute of Science
Rehovot, Israel
Dr. Alexandra Avgustinova
Institut de Recerca Sant Joan de Déu
Barcelona, Spain
Dr. Salvador Aznar Benitah
IRB Barcelona/ICREA
Barcelona, Spain
Dr. Eduard Batlle
IRB Barcelona/ICREA
Barcelona, Spain
Dr. Ana Luisa Correia
Champalimaud Foundation
Lisboa, Portugal
Dr. Christina Curtis
Stanford University School of Medicine
Stanford, CA, USA
Dr. Luis Diaz
Memorial Sloan Kettering Cancer Center
New York, NY, USA
Dr. Gretchen Diehl
Memorial Sloan Kettering Cancer Center
New York, NY, USA
Dr. Rebecca Fitzgerald
University of Cambridge
Cambridge, UK
Dr. Tyler Jacks
Koch Institute for Integrative Cancer Research at MIT
Cambridge, MA, USA
Dr. Núria López-Bigas
IRB Barcelona/ICREA
Barcelona, Spain
Dr. Iñigo Martincorena
Wellcome Sanger Institute
Cambridge, UK
Dr. Ángela Nieto
Institute of Neurosciences of Alicante- UMH
Alicante, Spain
Dr. Seishi Ogawa
Kyoto University
Kyoto, Japan
Dr. Elisa Oricchio
EPFL
Lausanne, Switzerland
Dr. Anne Rios
Princess Máxima Center for Pediatric Oncology
Utrecht, The Netherlands
Dr. Mike Stratton
Wellcome Sanger Institute
Hinxton, UK
Dr. Samra Turajlic
The Francis Crick Institute
London, UK
Dr. Logan Walsh
McGill University
Montreal, Canada
Dr. Richard White
Ludwig Institute for Cancer Research
Oxford, UK
Dr. Frank Winkler
DKFZ Heidelberg
Heidelberg, Germany
