Charting genome maintenance and synthetic lethality networks
Speaker: Daniel Durocher, PhD, The Lunenfeld-Tanenbaum Research Institute. Mount Sinai Hospital. Toronto. Canada
Organizers: IRB Barcelona
Date: Friday 31 January 2020, 12.00h
Place: Dolors Aleu room (Cluster II). Parc Cientific de Barcelona
Host: Travis Stracker, PhD - IRB Barcelona
The orchestration of DNA repair is of fundamental importance to the maintenance of genomic integrity and tumor suppression. DNA damage must be detected in the context of the varied chromatin landscape, its presence must be communicated throughout the cell to alter many ongoing processes, and the machinery that will mend the lesion must be recruited to the damage site. In my presentation, I will discuss our recent efforts in mapping genome maintenance pathways using genome-scale CRISPR/Cas9 screens in human cells. I will hightlight how these screens can be used to identify new genome stability factors, characterize drug responses and provide new insights into the genetic architecture of the genome stability network. I will also present how these screens can also identify potentially actionable synthetic lethal genetic interactions that could form the basis of new oncology drug discovery efforts.