Presentation
Organizer: IRB BioMed Seminars
Date / Time: Friday, March 6th at 12:00
Place: Auditorium
Speaker: Toni Gabaldón, Ph.D. - Group Leader IRB Barcelona, Comparative Genomics Lab, Mechanisms of Disease Programme - Group Leader Dual appointment with BSC.
Abstract:
Invasive fungal diseases such as candidiasis, caused by Candida species, are a major public health problem. They are difficult to diagnose and resistance to multiple antifungal drugs is increasingly reported, particularly in emerging species such as Candida glabrata, Candida parapsilosis, and Candida auris. Despite their common genus name, these pathogens are evolutionarily diverse and belong to different lineages where the ability to infect humans has emerged independently. Over the last years we have used in vitro evolution, and population genomics to understand the origin of the different pathogenic lineages, how they adapted to humans and how they become resistant to the drugs we use to fight their infections. Our research has charted genes selected during drug exposure and their associated fitness trade-offs, and has uncovered unexpected findings such as the prevalence of hybrid pathogens and a potential role of ploidy shifts in drug adaptation.
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar
The weekly seminars at IRB Barcelona are scientific events primarily addressed to the Institute’s research community and professionals in the biomedical field. Attendance is intended exclusively for individuals with a genuine and justified scientific interest in the seminar content. Registration should not be used to request supporting documents for visa or immigration purposes. For participants residing outside Spain, in-person attendance requires a formal invitation issued by an IRB Barcelona research group or department. Without such an invitation, access to the institute cannot be guaranteed. IRB Barcelona reserves the right to review and verify all seminar registrations.