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Dendritic cell and macrophage (metabolism) in homeostasis, cancer and obesity


Organizer: IRB BioMed Seminars

Speaker: Dr. Stefanie K. Wculek  - Novel mechanisms of atherosclerosis programme / Immunobiology Lab, Spanish National Center for Cardiovascular Research | CNIC (Madrid) and Innate Immune Biology Laboratory, IRB Barcelona.

Date: Friday, 13 January 2023 at 12PM

Place: Felix Serratosa Hall, PCB

Host: Salvador Aznar Benitah - Aging and Metabolism Programme Coordinator



Innate immune cells, such as dendritic cells and macrophages, colonize virtually every organ of the body. They have very potent immune functions that contribute to prevention or progression of diseases and can also regulate tissue homeostasis. However, our knowledge on the mechanisms controlling dendritic cell and macrophage behaviour and how this can be harnessed therapeutically is limited.
In this seminar, she will explore the potential of dendritic cells to control cancer progression and relapse. Their unpublished data show that the anti-cancer functions of dendritic cells depend on their metabolic plasticity. Moreover, she will reveal the metabolic diversity of tissue macrophages that is dictated by their organ of residence. In detail, they uncovered a tissue-specific vulnerability of macrophages that can be exploited to ameliorate obesity-associated disorders.
Overall, she will show how our better understanding of the biology of innate immune cells allows the modulation of their functionality to combat non-infectious diseases.


IRB BioMed Seminars

IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.


In collaboration with:

fundación bbva