Speaker: Mathew Garnett, PhD
Senior Group Leader
Somatic Genomics Programme
Wellcome Sanger Institute
Cambridge, UK.
Presentation
Organizer: IRB BioMed Seminars
Date: Friday, 18 September 2026, 12:00h
Place: Fèlix Serratosa, PCB
Host: Eduard Batlle, PhD. Program Coordinator and Group Leader - Colorectal Cancer Laboratory - Cancer Science Programme - IRB Barcelona.
Cancer progression is driven not only by genetic change, but also by the remarkable ability of cancer cells to adapt and shift between cellular states. In this talk, I will describe our efforts to understand how somatic mutations shape both cancer cell vulnerabilities and cell states, and how these effects are further reshaped by cellular plasticity. By integrating large-scale genetic perturbation, advanced cancer models and single-cell profiling, we aim to uncover general principles that govern cancer cell fitness, adaptation and therapeutic response, and to use these insights to identify new opportunities for treatment.
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.
The weekly seminars at IRB Barcelona are scientific events primarily addressed to the Institute’s research community and professionals in the biomedical field. Attendance is intended exclusively for individuals with a genuine and justified scientific interest in the seminar content. Registration should not be used to request supporting documents for visa or immigration purposes. For participants residing outside Spain, in-person attendance requires a formal invitation issued by an IRB Barcelona research group or department. Without such an invitation, access to the institute cannot be guaranteed. IRB Barcelona reserves the right to review and verify all seminar registrations.