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Mechanistic insights into the consequences of Chromosome segregation errors on cell physiology

4 Feb 20

Speaker: Prof. Dr. Stefano Santaguida, Group Leader, Department of Experimental Oncology, European Institute of Oncology. Assistant Professor of Molecular Biology, Department of Oncology and Hemato-Oncology, University of Milan, Italy.  



Organizers: IRB Barcelona
Date: Tuesday, 4th Feb 2020, 12.00h
Place: Fèlix Serratosa, Parc Cientific de Barcelona

Host: Marco Milán, PhD., Group Leader, IRB Barcelona, Mechanisms of Disease Programme.


Aneuploidy, defined as a chromosome number that is not a multiple of the haploid complement, is highly detrimental at both the organismal and cellular levels. Virtually all aspects of cell physiology are impacted by changes in the cell’s proteome brought about by an abnormal karyotype. Importantly, aneuploidy is associated with cancer. The aneuploid state is an almost universal feature of cancer cells and its high frequency in tumors is a hallmark of the malignant state. The goal of our work is to elucidate the impact of aneuploidy on cell physiology by identifying and characterizing at the molecular level the pathways deregulated in aneuploid cells.

Extraordinary MOD's Programme Seminar