Speaker: Jeong Ho Lee M.D., Ph.D1,2
1Graduate School of Medical Science and Engineering, Korea Advanced Institute Science and Technology (KAIST), Daejeon, Korea.
2 Sovargen Co. LTD., Daejeon, Korea
Presentation
Organizer: IRB BioMed Seminars
Date: Friday, 08 May 2026, 12:00h
Place: Fèlix Serratosa, PCB
Host: Prof. Núria López-Bigas, Group Leader - Biomedical Genomics Laboratory - Cancer Science Programme - IRB Barcelona.
Somatic mutations occur during cell division across all somatic lineages due to unavoidable DNA replication errors or damage. These mutations, also known as somatic mosaicism, are implicated in both cancer evolution and non-neoplastic disorders. Neural stem cells (NSCs) and their progenitors, which continue dividing throughout life, accumulate somatic mutations in the brain during development and aging. Over the past 15 years, our group has opened a new window into this field and provided molecular genetic evidence that somatic mutations in NSCs or their progenitors contribute to neurodevelopmental disorders and brain tumor evolution. In this seminar, I will present our recent findings on the cell of origin harboring the initial driver mutation in glioma, as well as the associated molecular evolution of these cells of origin and their tumor microenvironment.
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.
The weekly seminars at IRB Barcelona are scientific events primarily addressed to the Institute’s research community and professionals in the biomedical field. Attendance is intended exclusively for individuals with a genuine and justified scientific interest in the seminar content. Registration should not be used to request supporting documents for visa or immigration purposes. For participants residing outside Spain, in-person attendance requires a formal invitation issued by an IRB Barcelona research group or department. Without such an invitation, access to the institute cannot be guaranteed. IRB Barcelona reserves the right to review and verify all seminar registrations.