Catherine Elizabeth Willoughby

Unit:

Mechanisms of Disease

Position:

Alumni - Postdoctoral Fellow

Office:

EM01B24

Telephone:

+34 93 40 37123

Email:

catherine.willoughby@irbbarcelona.org

Left IRB Barcelona in January 2023

Research Group

Targeted protein degradation and drug discovery

Mecanismos de las Enfermedades

Selected group publications

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders

Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C

Angewandte Chemie (International Ed. Print),

(12 )

e202316730

- e202316730

(2024)

Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation

Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C

Chembiochem,

(10 )

e202300163

(2023)

Molecular glue degraders: From serendipity to hunting and design

Nieto-Barrado L; Domostegui A; Mayor-Ruiz C

In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.,

177

- 204

(2022)

Chasing molecular glue degraders: screening approaches

Domostegui, A; Nieto-Barrado, L; Perez-Lopez, C; Mayor-Ruiz, C

Chemical Society Reviews,

(13 )

5498

- 5517

(2022)

Identification and selectivity profiling of small-molecule degraders via multi-omics approaches

Scholes, NS; Mayor-Ruiz, C; Winter, GE

Cell Chemical Biology,

(7 )

1048

- 1060

(2021)

Rational discovery of molecular glue degraders via scalable chemical profiling

Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E

Nat Chem Bio,

(2020)

Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation

Mayor-Ruiz, C.1,*, Jaeger, M.G*, Bauer, S., Brand, M., Sin, C., Hanzl, A., Mueller, A.C., Menche, J., and Winter, G.E.1
1 co-corresponding; *Co-first authors

Molecular Cell,

(75 )

849

- 858

(2019)

Identification and characterization of cancer vulnerabilities via targeted protein degradation

Mayor-Ruiz, C., and Winter, G.E

Drug Discov Today Technol,

(31 )

- 90

(2019)

ERF deletion rescues RAS deficiency in mouse ES cells