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Investigación

A la vanguardia de la biomedicina

Publicaciones sobre Investigación

Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation
Duran-Arqué, B; Cañete, M; Castellazzi, CL; Bartomeu, A; Ferrer-Caelles, A; Reina, O; Caballé, A; Gay, M; Arauz-Garofalo, G; Belloc, E; Mendez, R
GENOME BIOLOGY
23
1
192 -
2022
Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors
Rivas, EI; Linares, J; Zwick, M; Gómez-Llonin, A; Guiu, M; Labernadie, A; Badia-Ramentol, J; Lladó, A; Bardia, L; Pérez-Núñez, I; Martínez-Ciarpaglini, C; Tarazona, N; Sallent-Aragay, A; Garrido, M; Celià-Terrassa, T; Burgués, O; Gomis, RR; Albanell, J; Calon, A
Nature Communications
13
1
5310 -
2022
The lysosomal proteome of senescent cells contributes to the senescence secretome
Rovira, M; Sereda, R; Pladevall-Morera, D; Ramponi, V; Marin, I; Maus, M; Madrigal-Matute, J; Díaz, A; García, F; Muñoz, J; Cuervo, AM; Serrano, M
AGING CELL
21
10
e13707 -
2022
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
Bernués, J; Izquierdo-Boulstridge, A; Reina, O; Castejón, L; Fernández-Castañer, E; Leal, N; Guerrero-Pepinosa, N; Bonet-Costa, C; Vujatovic, O; Climent-Cantó, P; Azorín, F
NUCLEIC ACIDS RESEARCH
50
16
9212 -
9225
2022
Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure
Riera-Escamilla, A; Vockel, M; Nagirnaja, L; Xavier, MJ; Carbonell, A; Moreno-Mendoza, D; Pybus, M; Farnetani, G; Rosta, V; Cioppi, F; Friedrich, C; Oud, MS; van der Heijden, GW; Soave, A; Diemer, T; Ars, E; Sánchez-Curbelo, J; Kliesch, S; O'Bryan, MK; Ruiz-Castañe, E; Azorín, F; Veltman, JA; Aston, KI; Conrad, DF; Tüttelmann, F; Krausz, C
AMERICAN JOURNAL OF HUMAN GENETICS
109
8
1458 -
1471
2022
DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
Barissi, S; Sala, A; Wieczór, M; Battistini, F; Orozco, M
NUCLEIC ACIDS RESEARCH
50
16
9105 -
9114
2022
Discovering the drivers of clonal hematopoiesis
Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Communications
13
1
4267 -
2022
A single WNT enhancer drives specification and regeneration of the Drosophila wing
Gracia-Latorre, E; Pérez, L; Muzzopappa, M; Milán, M
Nature Communications
13
1
4794 -
2022
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
Alvarez, MM; Biayna, J; Supek, F
Nature Communications
13
1
4520 -
2022
PerSVade: personalized structural variant detection in any species of interest
Schikora-Tamarit, MA; Gabaldón, T
GENOME BIOLOGY
23
1
175 -
2022
The impact of rare germline variants on human somatic mutation processes
Vali-Pour, M; Lehner, B; Supek, F
Nature Communications
13
1
3724 -
2022
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Delaunay, S; Pascual, G; Feng, BH; Klann, K; Behm, M; Hotz-Wagenblatt, A; Richter, K; Zaoui, K; Herpel, E; Munch, C; Dietmann, S; Hess, J; Benitah, SA; Frye, M
NATURE
607
7919
593 -
2022
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E
Nature Cancer
3
9
1052 -
2022
BioExcel Building Blocks Workflows (BioBB-Wfs), an integrated web-based platform for biomolecular simulations
Bayarri, G; Andrio, P; Orozco, M; Gelpí, JL
NUCLEIC ACIDS RESEARCH
50
W1
W99 -
W107
2022
Chasing molecular glue degraders: screening approaches
Domostegui, A; Nieto-Barrado, L; Perez-Lopez, C; Mayor-Ruiz, C
CHEMICAL SOCIETY REVIEWS
51
13
5498 -
5517
2022
Conformational ensemble of the TNF-derived peptide solnatide in solution
Martin-Malpartida, P; Arrastia-Casado, S; Farrera-Sinfreu, J; Lucas, R; Fischer, H; Fischer, B; Eaton, DC; Tzotzos, S; Macias, MJ
Computational and Structural Biotechnology Journal
20
2082 -
2090
2022
Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors
Willis, JR; Saus, E; Iraola-Guzman, S; Ksiezopolska, E; Cozzuto, L; Bejarano, LA; Andreu-Somavilla, N; Alloza-Trabado, M; Blanco, A; Puig-Sola, A; Broglio, E; Carolis, C; Ponomarenko, J; Hecht, J; Gabaldón, T
npj Biofilms and Microbiomes
8
1
38 -
2022
Natural killer cells act as an extrinsic barrier for in vivo reprogramming
Melendez, E; Chondronasiou, D; Mosteiro, L; de Villarreal, JM; Fernandez-Alfara, M; Lynch, CJ; Grimm, D; Real, FX; Alcami, J; Climent, N; Pietrocola, F; Serrano, M
DEVELOPMENT
149
8
dev200361 -
2022
Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback
Tartour, K; Andriani, F; Folco, EG; Letkova, D; Schneider, R; Saidi, I; Sato, T; Welz, PS; Benitah, SA; Allier, C; Padmanabhan, K
NATURE STRUCTURAL & MOLECULAR BIOLOGY
29
6
549 -
2022
Mutational signatures are markers of drug sensitivity of cancer cells
Levati, J; Salvadores, M; Fuster-Tormo, F; Supek, F
Nature Communications
13
1
2926 -
2022
Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation
Suñer, C; Sibilio, A; Martín, J; Castellazzi, CL; Reina, O; Dotu, I; Caballé, A; Rivas, E; Calderone, V; Díez, J; Nebreda, AR; Méndez, R
eLife
11
e75873 -
2022
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R;...
Nature Cancer
3
4
418 -
2022
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Chondronasiou, D; Gill, D; Mosteiro, L; Urdinguio, RG; Berenguer, A; Aguilera, M; Durand, S; Aprahamian, F; Nirmalathasan, N; Abad, M; Martin-Herranz, DE; Otto-Attolini, CS; Prats, N; Kroemer, G; Fraga, MF; Reik, W; Serrano, M
AGING CELL
21
3
e13578 -
2022
Proteomic tools for the quantitative analysis of artificial peptide libraries: detection and characterization of target-amplified PD-1 inhibitors
Gay, M; Díaz-Lobo, M; Gusi-Vives, M; Arauz-Garofalo, G; Vilanova, M; Giralt, E; Vilaseca, M; Guardiola, S
CHEMBIOCHEM
23
12
e202200152 -
2022
Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission
Calvet, J; Berenguer-Llergo, A; Gay, M; Massanella, M; Domingo, P; Llop, M; Sánchez-Jiménez, E; Arévalo, M; Carrillo, J; Albiñana, N; Arauz-Garofalo, G; Orellana, C; Delgado, JF; Serrano, A; Llobell, A; Graell, E; García-Manrique, M; Moreno, M; Galisteo, C; Casado, E; Navarro, N; Gómez, A; Garcia-Cirera, S; Rusiñol, M; Costa, E; Clotet, B;...
Scientific Reports
12
1
640 -
2022
HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings: HTSDSF Explorer, a tool for DSF screenings
Martin-Malpartida, P; Hausvik, E; Underhaug, J; Torner, C; Martinez, A; Macias, MJ
JOURNAL OF MOLECULAR BIOLOGY
434
11
167372 -
2022
Overcoming TGF beta-mediated immune evasion in cancer
Tauriello, DVF; Sancho, E; Batlle, E
NATURE REVIEWS CANCER
22
1
25 -
44
2022
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation
Cabré, A; Verdaguer, X; Riera, A
CHEMICAL REVIEWS
122
1
269 -
339
2022
Heteroplasmy of wild type mitochondrial DNA variants in mice causes metabolic heart disease with pulmonary hypertension and frailty
Lechuga-Vieco AV
Circulation
2022
Metabolism of tissue macrophages in homeostasis and pathology
Wculek SK#, Dunphy G, Heras-Murillo I, Mastrangelo A, Sancho D#
(#) Corresponding author
Cellular and Molecular Immunology
19(3):384-408
2022
AutoScanJ: A Suite of ImageJ Scripts for Intelligent Microscopy
Tosi, S; Lladó, A; Bardia, L; Rebollo, E; Godo, A; Stockinger, P; Colombelli, J
FRONTIERS IN BIOINFORMATICS
1
627626 -
2021
The long non-coding RNA landscape of Candida yeast pathogens
Hovhannisyan, H; Gabaldon, T
Nature Communications
12
1
7317 -
2021
Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata
Ksiezopolska, E; Schikora-Tamarit, MA; Beyer, R; Nunez-Rodriguez, JC; Schuller, C; Gabaldon, T
CURRENT BIOLOGY
31
23
5314 -
2021
Structural basis for substrate specificity of heteromeric transporters of neutral amino acids
Rodriguez, CF; Escudero-Bravo, P; Diaz, L; Bartoccioni, P; Garcia-Martin, C; Gilabert, JG; Boskovic, J; Guallar, V; Errasti-Murugarren, E; Llorca, O; Palacin, M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
118
49
e2113573118 -
2021
Dietary palmitic acid promotes a prometastatic memory via Schwann cells
Pascual, G; Dominguez, D; Elosua-Bayes, M; Beckedorff, F; Laudanna, C; Bigas, C; Douillet, D; Greco, C; Symeonidi, A; Hernandez, I; Gil, SR; Prats, N; Bescos, C; Shiekhattar, R; Amit, M; Heyn, H; Shilatifard, A; Benitah, SA
NATURE
599
7885
485 -
2021
Control of hormone-driven organ disassembly by ECM remodeling and Yorkie-dependent apoptosis
Fraire-Zamora, JJ; Tosi, S; Solon, J; Casanova, J
CURRENT BIOLOGY
31
23
5261 -
2021
Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in App(NL-G-F), App(NL-F), and 3xTg-AD mouse models
Pauls, E; Bayod, S; Mateo, L; Alcalde, V; Juan-Blanco, T; Sanchez-Soto, M; Saido, TC; Saito, T; Berrenguer-Llergo, A; Attolini, CSO; Gay, M; de Oliveira, E; Duran-Frigola, M; Aloy, P
Genome Medicine
13
1
168 -
2021
Sub-centrosomal mapping identifies augmin-gamma TuRC as part of a centriole-stabilizing scaffold
Schweizer, N; Haren, L; Dutto, I; Viais, R; Lacasa, C; Merdes, A; Luders, J
Nature Communications
12
1
6042 -
2021
Conformational landscape of multidomain SMAD proteins
Gomes, T; Martin-Malpartida, P; Ruiz, L; Aragón, E; Cordeiro, TN; Macias, MJ
Computational and Structural Biotechnology Journal
19
5210 -
5224
2021
MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate
Gutierrez-Prat, N; Cubillos-Rojas, M; Canovas, B; Kuzmanic, A; Gupta, J; Igea, A; Llonch, E; Gaestel, M; Nebreda, AR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
118
29
e2024562118 -
2021
Probing allosteric regulations with coevolution-driven molecular simulations
Colizzi, F; Orozco, M
Science Advances
7
37
eabj0786 -
2021
Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development
Viais, R; Fariña-Mosquera, M; Villamor-Payà, M; Watanabe, S; Palenzuela, L; Lacasa, C; Lüders, J
eLife
10
e67989 -
2021
In silico saturation mutagenesis of cancer genes
Muiños, F; Martínez-Jiménez, F; Pich, O; Gonzalez-Perez, A; Lopez-Bigas, N
NATURE
596
7872
428 -
2021
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M
DEVELOPMENTAL CELL
56
14
2043 -
2021
Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development
Avgustinova, A; Laudanna, C; Pascual-García, M; Rovira, Q; Djurec, M; Castellanos, A; Urdiroz-Urricelqui, U; Marchese, D; Prats, N; Van Keymeulen, A; Heyn, H; Vaquerizas, JM; Benitah, SA
Cell Stem Cell
28
10
1790 -
2021
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
Scholes, NS; Mayor-Ruiz, C; Winter, GE
Cell Chemical Biology
28
7
1048 -
1060
2021
Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins
Torres, AG; Rodríguez-Escribà, M; Marcet-Houben, M; Vieira, HGS; Camacho, N; Catena, H; Recio, MM; Rafels-Ybern, A; Reina, O; Torres, FM; Pardo-Saganta, A; Gabaldón, T; Novoa, EM; de Pouplana, LR
NUCLEIC ACIDS RESEARCH
49
12
7011 -
7034
2021
Bioactivity descriptors for uncharacterized chemical compounds
Bertoni, M; Duran-Frigola, M; Badia-i-Mompel, P; Pauls, E; Orozco-Ruiz, M; Guitart-Pla, O; Alcalde, V; Diaz, VM; Berenguer-Llergo, A; Brun-Heath, I; Villegas, N; de Herreros, AG; Aloy, P
Nature Communications
12
1
3932 -
2021