Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R; Santos, C; Villanueva, A; Attolini, CSO; Sancho, E; Palmer, HG; Tabernero, J; Stratton, MR; de Kruif, J; Logtenberg, T; Clevers, H; Price, LS; Vries, RGJ; Batlle, E; Throsby, M