Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Herpers B; Eppink B; James MI; Cortina C; Cañellas-Socias A; Boj SF; Hernando-Momblona X; Glodzik D; Roovers RC; van de Wetering M; Bartelink-Clements C; Zondag-van der Zande V; Mateos JG; Yan K; Salinaro L; Basmeleh A; Fatrai S; Maussang D; Lammerts van Bueren JJ; Chicote I; Serna G; Cabellos L; Ramírez L; Nuciforo P; Salazar R; Santos C; Villanueva A; Stephan-Otto Attolini C; Sancho E; Palmer HG; Tabernero J; Stratton MR; de Kruif J; Logtenberg T; Clevers H; Price LS; Vries RGJ; Batlle E; Throsby M