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Finding the needle in the haystack – target identification of anti-cancer small molecules [IRB Research Nodes Seminar]

15 Jun 22

Speaker: Dr. Juan Manuel Povedano Selfa 

Postdoctoral Researcher

McFadden’s Laboratory, Department of Biochemistry, UT Southwestern Medical Center, Texas, USA




Host: Manuel Serrano

Node: Preclinical Models of Cancer / Preclinical Models of Disease  

Date: Wednesday 15 June 2022, 12.00h



Identification of the mechanism of action of small molecules is one of the main roadblocks in drug development. In the last years, I have developed genetic and chemoproteomic tools to unequivocally identify the target of small molecules with anti-cancer activity. These tools have led to the discovery of the target of a small molecule currently in clinical trials for the treatment of Ewing sarcoma.