Speaker: Dr. Juan Manuel Povedano Selfa
McFadden’s Laboratory, Department of Biochemistry, UT Southwestern Medical Center, Texas, USA
Host: Manuel Serrano
Node: Preclinical Models of Cancer / Preclinical Models of Disease
Date: Wednesday 15 June 2022, 12.00h
Identification of the mechanism of action of small molecules is one of the main roadblocks in drug development. In the last years, I have developed genetic and chemoproteomic tools to unequivocally identify the target of small molecules with anti-cancer activity. These tools have led to the discovery of the target of a small molecule currently in clinical trials for the treatment of Ewing sarcoma.