Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope

Year:

2019

Authors

Orellana, L; Thorne, AH; Lema, R; Gustavsson, J; Parisian, AD; Hospital, A; Cordeiro, TN; Bernadó, P; Scott, AM; Brun-Heath, I; Lindahl, E; Cavenee, WK; Furnari, FB; Orozco, M

Journal:

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Number:

Volume:

116

Init page:

10009

Last page:

10018

https://doi.org/10.1073/pnas.1821442116