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Fate versus free will; how does the environment shape early tumour survival?

Presentation

Organizer: IRB BioMed Seminars

Date / Time: ​​ Friday, October 30 at 12:00
Place: Auditorium PCB

Speaker: Dr. María Alcolea PhD, Associate Professor, Cambridge Stem Cell Institute/ Department of Physiology, Development and Neuroscience, University of Cambridge, UK.

Host: Prof. Alejo Rodríguez Fraticelli. Group Leader Quantitative Stem Cell Dynamics Lab, Aging and Metabolism Programme.



 

 

 

Abstract

  
Building on our previous work on mutant clone dynamics in early tumorigenesis, my laboratory has now revealed how nascent tumour cells actively remodel their microenvironment to create a mesenchymal niche that promotes tumour persistence and progression. Our recent contributions establish tumour-stroma crosstalk as a critical determinant of the earliest stages of cancer development and identify the precancerous niche as a potential target for cancer prevention.

 

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