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Gene regulation of human cell systems

Presentation

Organizer: IRB BioMed Seminars

Date: Friday 28 June 2024, 12:00h

Place: Fèlix Serratosa Hall, PCB

Speaker: Roser Vento-Tormo, PhD. Group Leader Cellular Genetics Programme - Wellcome Sanger Institute - Cambridge | UK

Host: Salvador Aznar, PhD - Group Leader - Stem Cells and Cancer -  Aging and Metabolism Programme - IRB Barcelona

 

Abstract

The study of human tissues requires a systems biology approach. Their development starts in utero and during adulthood, they change their organization and cell composition. Our team has integrated comprehensive maps of human developing and adult tissues generated by us and others using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy. We utilise these maps to guide the development and interpretability of in vitro models. To do so, we develop and apply bioinformatic tools that allow us to quantitatively compare both systems and predict changes.

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