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SYNTHETIC DEVELOPMENTAL BIOLOGY: Cross-species comparison and manipulation of organoids

Seminaris IRB Barcelona BioMed
26 nov. 21

Speaker: Miki Ebisuya, PhD., Group Leader, EMBL Barcelona

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Presentation

Organizer: IRB Barcelona

Date: Friday 26 November, 12PM

Place: Auditorium Antoni Caparrós, PCB

Title: "SYNTHETIC DEVELOPMENTAL BIOLOGY: Cross-species comparison and manipulation of organoids"

Host: Marco Milán, PhD - Development and Growth Control Lab - Mechanisms of Disease Programme - IRB Barcelona

Abstract:

While mechanisms of embryonic development are well conserved among mammals, the progression speed tends to be slower in larger species. To study differences in time between species, my group uses in vitro systems. We have recently recapitulated the segmentation clock, oscillatory gene expression during early development, from human and mouse pluripotent stem cells. The oscillation period of the human segmentation clock is 5-6 hours, while the mouse period is 2-3 hours. We found that this period difference between species stems from slower biochemical reactions in human cells, including slower protein degradation and longer delays in gene expression processes. Now we are extending this approach of cross-species comparison to other mammalian species, including cows and rhinos, and other developmental processes. In parallel, we develop genetic tools to manipulate developmental processes and organoids.

 

Biomed Seminar