Speaker: Dr. Guillermo Martínez Corrales
Molecular Biology Institute of Barcelona (IBMB-CSIC), Department of Cells and Tissues, Barcelona, Spain
Host: Dr. Marco Milán, Group Leader - Development and Growth Control Laboratory - IRB Barcelona
Node: Cell Pathophysiology / Preclinical Models of Disease
Date: Wednesday 14 February 2024, 12.00h
Place: Auditorium Room
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.
Transcriptional memory, the enduring impact of transient transcriptional activity, poses intriguing questions in understanding developmental processes and responses to environmental stimuli. I use the fly to explore the effects of transcription factors in establishing transcriptional memory. I will focus my talk on the Forkhead Box O (FOXO) transcription factors, known regulators of metabolic homeostasis and longevity, in establishing transcriptional memory. In particular, the tissue-specific activation of Drosophila FOXO allows for controlled exploration of transcriptional memory in the context of ageing. The unique characteristics of this fly modelmakes it ideal to explore longevity determination in vivo in a relatively short time. By shedding light on the lasting impact of transient transcriptional events, we contribute to a deeper understanding of aging processes, offering potential avenues for therapeutic interventions to enhance healthspan and mitigate age-related diseases.