Patrick Aloy

    Research Group: 
    Structural Bioinformatics and Network Biology
    Unit: 
    MECHANISMS OF DISEASE
    Position: 
    Group Leader
    Office: 
    CL01C72-73
    Telephone: 
    +34 93 40 39690
    Email: 
    paloy@irbbarcelona.org

    ICREA Research Professor, ERC Consolidator Grant

     

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    Born in Barcelona in 1972. He obtained his BSc in Biochemistry (1996), MSc in Biotechnology (1998) and PhD in Biochemistry & Molecular Biology (2000) from the Autonomous University of Barcelona. He then joined the Structural Bioinformatics Group at the European Molecular Biology Laboratory (2001) where he did his postdoctoral training and became Staff Scientist (2003).

    Since April 2006, Patrick Aloy is an ICREA Research Professor and Principal Investigator of the Structural Bioinformatics Lab in the Institute for Research in Biomedicine (IRB Barcelona).
    His main scientific interests are in the field of structural bioinformatics, in particular, the use of high-resolution three-dimensional structures to reveal the molecular details of how macromolecular complexes and cell networks operate.

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    Patrick Aloy: "Redes de vida"

    Selected group publications

    Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
    Lidia Mateo , Miquel Duran-Frigola , Albert Gris-Oliver , Marta Palafox , Maurizio Scaltriti , Pedram Razavi , Sarat Chandarlapaty , Joaquin Arribas , Meritxell Bellet , Violeta Serra , Patrick Aloy
    Genome Med, 12 (1), 78 (2020)
    Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
    Miquel Duran-Frigola, Eduardo Pauls, Oriol Guitart-Pla, Martino Bertoni, Víctor Alcalde, David Amat, Teresa Juan-Blanco, Patrick Aloy
    Nat Biotechnol, 38 (9), 1087 (2020)
    Formatting biological big data for modern machine learning in drug discovery
    Duran-Frigola M., Fernandez-Torras A., Bertoni M., Aloy P.
    Wiley Interdiscip Rev Comput Mol, 9 (6), (2019)
    Formatting biological big data for modern machine learning in drug discovery
    Duran-Frigola M., Fernández-Torras A., Bertoni M., Aloy P.
    Wiley Interdiscip. Rev. Comput. Mol., (2018)
    Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer
    Jaeger S, Igea A, Arroyo R, Alcalde V, Canovas B, Orozco M, Nebreda AR and Aloy P.
    Cancer Res, 77 (2), 459-469 (2017)
    Residues Coevolution Guides the Systematic Identification of Alternative Functional Conformations in Proteins
    Sfriso P, Duran-Frigola M, Mosca R, Emperador A, Aloy P and Orozco M.
    Structure, 24 (1), 116-26 (2016)
    A chemo-centric view of human health and disease
    Duran-Frigola M, Rossell D and Aloy P.
    Nat Commun, 5 5676 (2014)
    Interactome3D: adding structural details to protein networks
    Mosca R, Céol A and Aloy P.
    Nat Methods, 10 (1), 47-53 (2013)
    Structural systems pharmacology: the role of 3D structures in next-generation drug development
    Duran-Frigola M, Mosca R and Aloy P.
    Chem Biol, 20 (5), 674-84 (2013)
    The role of structural disorder in the rewiring of protein interactions through evolution
    Mosca R, Pache RA and Aloy P.
    Mol Cell Proteomics, 11 (7), M111.01496 (2012)
    Interactome mapping suggests new mechanistic details underlying Alzheimer's disease
    Soler-López M, Zanzoni A, Lluís R, Stelzl U and Aloy P.
    Genome Res, 21 (3), 364-76 (2011)
    Novel peptide-mediated interactions derived from high-resolution 3-dimensional structures
    Stein A and Aloy P.
    Plos Comput Biol, 6 (5), e1000789 (2010)
    Uncovering new substrates for Aurora A kinase
    Sardon T, Pache RA, Stein A, Molina H, Vernos I and Aloy P.
    Embo Rep, 11 (12), 977-84 (2010)
    Full publication list