Structural and Computational BiologyStructural Bioinformatics and Network Biology

"For every complex problem there's an answer that is clear, simple, and wrong". H.L. Mencken.

Structural Bioinformatics and Network Biology
Group Leader

ICREA Research Professor, ERC Consolidator Grant

+34 93 40 39690

Meet Our Scientists Videos

Patrick Aloy: "Redes de vida"

Modern molecular and cell biology no longer focus only on single macromolecules but now look into pathways, complexes or even entire organisms. The many genome-sequencing projects have provided a near complete list of the components present in an organism, and post-genomic projects have aimed to catalogue the relationships between them.

The emerging field of systems biology is now centered mainly on unravelling these relationships. For example, an understanding of metabolic and signalling pathways or gene-regulatory networks relies on detailed knowledge of protein–metabolite, protein–protein and protein–nucleic-acid interactions. However, a full understanding of how molecules interact can be attained only from three-dimensional (3D) structures, as these provide crucial atomic details about binding. These details allow a more rational design of experiments to disrupt an interaction and therefore to perturb any system in which the interaction is involved.

Structural Bioinformatics and Network Biology Group Webpage

Our main scientific interests lie in the field of structural bioinformatics, in particular, the use of high-resolution 3D structures to reveal the molecular bases of how macromolecular complexes and cell networks operate. Structural information for interacting cellular components willimprove our understanding of the whole-cell framework at atomic level, thereby contributing to biological systems modelling.

Jaeger S, Igea A, Arroyo R, Alcalde V, Canovas B, Orozco M, Nebreda AR and Aloy P.
Cancer Res, 77 (2), 459-469 (2017)
Sfriso P, Duran-Frigola M, Mosca R, Emperador A, Aloy P and Orozco M.
Structure, 24 (1), 116-26 (2016)
Duran-Frigola M, Rossell D and Aloy P.
Nat Commun, 5 5676 (2014)
Mosca R, Céol A and Aloy P.
Nat Methods, 10 (1), 47-53 (2013)
Duran-Frigola M, Mosca R and Aloy P.
Chem Biol, 20 (5), 674-84 (2013)
Mosca R, Pache RA and Aloy P.
Mol Cell Proteomics, 11 (7), M111.01496 (2012)
Soler-López M, Zanzoni A, Lluís R, Stelzl U and Aloy P.
Genome Res, 21 (3), 364-76 (2011)
Stein A and Aloy P.
Plos Comput Biol, 6 (5), e1000789 (2010)
Sardon T, Pache RA, Stein A, Molina H, Vernos I and Aloy P.
Embo Rep, 11 (12), 977-84 (2010)

This group receives financial support from the following sources:

  • ICREA (Institució Catalana de Recerca i Estudis Avançats)(Catalan Institute of Research and Advanced Studies)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Science Festival 2016, Parc de la Ciutadella.</p>
24 May 2017

Los próximos 27 y 28 de mayo, el Parc de la Ciutadella de Barcelona será el anfitrión de la undécima edición de la Fiesta de la Ciencia, un evento consolidado que reúne cerca de un centenar de acti

9 Feb 2017

La revista bimensual Clinical OMICs entrevista a Patrick Aloy, investigador ICREA y líder del Laboratorio de Bioinformática Estructural y Biología de Redes en el IRB Barcelona, sobre su estudio pub

31 Ene 2017

Patrick Aloy, investigador ICREA del IRB Barcelona, ha dicho en 'L'Entrevista' de La Xarxa Televisió, que la investigación en Alzheimer está en la fase todavía de

<p>Patrick Aloy, ICREA Research Professor & ERC Consolidator Grant.</p>
31 Dic 2016

El periódico local "Regió 7" dedica un artículo al estudio dirigido por Patrick Aloy, investigador ICREA y líder del laboratorio de Bioinformática Estructural y Biología de Redes del IRB Barcelona.

Upcoming events

24 Ene
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Dr Travis Johnson, Lecturer, Head - Drosophila developmental biology group, Faculty of Science School of Biological Sciences, Australia
26 Ene
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Alejandra Bruna, PhD Associate Scientist Cancer Research UK Cambridge Institute University of Cambridge
31 Ene
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Marta Shahbazi, Postdoctoral Fellow Department of Physiology, Development and Neuroscience, University of Cambridge, UK