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Investigación

A la vanguardia de la biomedicina

Adrian Alvarez

Unit:
Position:
Alumni - PhD Student
Office:
EM01B51-52
Telephone:
+34 93 40 34982
Left IRB Barcelona in October 2022
Research Group

Selected group publications

TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages
Henriques, Ana; Salvany-Celades, Maria; Nieto, Paula; Palomo-Ponce, Sergio; Sevillano, Marta; Hernando-Momblona, Xavier; Middendorp-Guerra, Emily; Llanses Martinez, Montserrat; Haak, Elisabeth Marjolein; Nieto, Juan; Caratú, Ginevra; Marchese, Domenica; Ruiz Gil, Max; Tosi, Sebastien; Suckert, Theresa; Badia-Ramentol, Jordi; Caballé-Mestres,...
Nature Genetics,
(2025)
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Centonze, Alessia; Roura, Adrià-Jaume; Novillo-Font, Meritxell; Giordano, Cristina; Hernando-Momblona, Xavier; Llanses, Montserrat; Prats, Paula; Sevillano, Marta; Cabot, Débora; Novell, Mireia; Pabst, Gabriel; Andersch, Florian; Cañellas-Socias, Adrià; Zhang, Chong; Giakoumakis, Nikolaos-Nikiforos; Sparks, Hugh; Dunsby, Chris; Colombelli,...
Cancer Discovery,
(2025)
Mechanisms of metastatic colorectal cancer
Cañellas-Socias, Adrià; Sancho, Elena; Batlle, Eduard
Nature Reviews Gastroenterology & Hepatology,
21
(9 )
609
- 625
(2024)
Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X;...
Nature,
611
(7936 )
603
- 613
(2022)
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E
Nature Cancer,
3
(9 )
1052
(2022)
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R;...
Nature Cancer,
3
(4 )
418
(2022)
Overcoming TGF beta-mediated immune evasion in cancer
Tauriello, DVF; Sancho, E; Batlle, E
Nature Reviews Cancer,
22
(1 )
25
- 44
(2022)
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral, C; Stanisavljevic, J; Hernando-Momblona, X; Mereu, E; Alvarez-Varela, A; Cortina, C; Stork, D; Slebe, F; Turon, G; Whissell, G; Sevillano, M; Merlos-Suárez, A; Casanova-Martí, A; Moutinho, C; Lowe, SW; Dow, LE; Villanueva, A; Sancho, E; Heyn, H; Batlle, E
Cell Stem Cell,
26
(6 )
845
(2020)
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E; Massagué, J
Immunity,
50
(4 )
924
- 940
(2019)