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Investigación

A la vanguardia de la biomedicina

Publicaciones institucionales seleccionadas

The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Pascual, R; Martín, J; Salvador, F; Reina, O; Chanes, V; Millanes-Romero, A; Suñer, C; Fernández-Miranda, G; Bartomeu, A; Huang, YS; Gomis, RR; Méndez, R
Science Advances
6
(20 )
eaax3868 -
(2020)
Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols
Cabre, A; Rafael, S; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A
Angewandte Chemie (International Ed. Print)
59
(19 )
7521 -
7527
(2020)
Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio, L; Milán, M
Developmental Cell
52
(5 )
659 -
+
(2020)
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Hernández-Alvarez, MI; Sebastián, D; Vives, S; Ivanova, S; Bartoccioni, P; Kakimoto, P; Plana, N; Veiga, SR; Hernández, V; Vasconcelos, N; Peddinti, G; Adrover, A; Jové, M; Pamplona, R; Gordaliza-Alaguero, I; Calvo, E; Cabré, N; Castro, R; Kuzmanic, A; Boutant, M; Sala, D; Hyotylainen, T; Oresic, M; Fort, J; Errasti-Murugarren, E; Rodrígues, CMP; Orozco, M; Joven, J; Cantó, C; Palacin, M; Fernández-Veledo, S; Vendrell, J; Zorzano, A
Cell
177
(4 )
881 -
+
(2019)
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh, B; Banduseela, VC; Chiesa, G; Martínez-Cristóbal, P; Rauch, JN; Nath, SR; Schwarz, DMC; Shao, H; Marin-Argany, M; Di Sanza, C; Giorgetti, E; Yu, ZG; Pieratelli, R; Felli, IC; Brun-Heath, I; García, J; Nebreda, AR; Gestwicki, JE; Lieberman, AP; Salvatella, X
Nature Communications
10
(1 )
3562 -
(2019)
Evolutionary and functional patterns of shared gene neighbourhood in fungi
Marcet-Houben, M; Gabaldón, T
Nature Microbiology
4
(12 )
2383 -
2392
(2019)
The mutational footprints of cancer therapies
Pich, O; Muiños, F; Lolkema, MP; Steeghs, N; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Genetics
51
(12 )
1732 -
+
(2019)
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Lindeboom, RGH; Vermeulen, M; Lehner, B; Supek, F
Nature Genetics
51
(11 )
1645 -
+
(2019)
Atomic structure of the Epstein-Barr virus portal
Machón, C; Fàbrega-Ferrer, M; Zhou, DM; Cuervo, A; Carrascosa, JL; Stuart, DI; Coll, M
Nature Communications
10
(1 )
3891 -
(2019)
Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
Cuervo, A; Fàbrega-Ferrer, M; Machón, C; Conesa, JJ; Fernández, FJ; Pérez-Luque, R; Pérez-Ruiz, M; Pous, J; Vega, MC; Carrascosa, JL; Coll, M
Nature Communications
10
(1 )
3746 -
(2019)
An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases
Aranda, J; Terrazas, M; Gómez, H; Villegas, N; Orozco, M
Nature Catalysis
2
(6 )
544 -
552
(2019)
The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry
Terrazas, M; Genna, V; Portella, G; Villegas, N; Sánchez, D; Arnan, C; Pulido-Quetglas, C; Johnson, R; Guigó, R; Brun-Heath, I; Aviñó, A; Eritja, R; Orozco, M
Chem
5
(6 )
1619 -
1631
(2019)
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo, A; Topal, B; Kunze, MBA; Aranda, J; Chiesa, G; Mungianu, D; Bernardo-Seisdedos, G; Eftekharzadeh, B; Gairí, M; Pierattelli, R; Felli, IC; Diercks, T; Millet, O; García, J; Orozco, M; Crehuet, R; Lindorff-Larsen, K; Salvatella, X
Nature Communications
10
(1 )
2034 -
(2019)
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Errasti-Murugarren, E; Fort, J; Bartoccioni, P; Díaz, L; Pardon, E; Carpena, X; Espino-Guarch, M; Zorzano, A; Ziegler, C; Steyaert, J; Fernández-Recio, J; Fita, I; Palacín, M
Nature Communications
10
(1 )
1807 -
(2019)
Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit
Picchioni, D; Antolin-Fontes, A; Camacho, N; Schmitz, C; Pons-Pons, A; Rodríguez-Escribà, M; Machallekidou, A; Güler, MN; Siatra, P; Carretero-Junquera, M; Serrano, A; Hovde, SL; Knobel, PA; Novoa, EM; Solà-Vilarrubias, M; Kaguni, LS; Stracker, TH; de Pouplana, LR
Cell Reports
27
(1 )
40 -
+
(2019)
An In-Depth Look at DNA Crystals through the Prism of Molecular Dynamics Simulations
Kuzmanic, A; Dans, PD; Orozco, M
Chem
5
(3 )
649 -
663
(2019)
Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues
Benhra, N; Barrio, L; Muzzopappa, M; Milán, M
Developmental Cell
47
(2 )
161 -
+
(2018)
Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes
Pich, O; Muiños, F; Sabarinathan, R; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N
Cell
175
(4 )
1074 -
+
(2018)
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β
Romero, M; Sabaté-Pérez, A; Francis, VA; Castrillón-Rodriguez, I; Díaz-Ramos, A; Sánchez-Feutrie, M; Durán, X; Palacín, M; Moreno-Navarrete, JM; Gustafson, B; Hammarstedt, A; Fernández-Real, JM; Vendrell, J; Smith, U; Zorzano, A
Nature Cell Biology
20
(4 )
443 -
+
(2018)
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
Duch A; Canal B; Barroso S; García-Rubio M; Seisenbacher G; Aguilera A; De Nadal E; Posas F
Nature Communications
9
(1 )
379 -
(2018)
A versatile drug delivery system targeting senescent cells
Muñoz-Espín, D; Rovira, M; Galiana, I; Giménez, C; Lozano-Torres, B; Paez-Ribes, M; Llanos, S; Chaib, S; Muñoz-Martín, M; Ucero, AC; Garaulet, G; Mulero, F; Dann, SG; VanArsdale, T; Shields, DJ; Bernardos, A; Murguía, JR; Martínez-Máñez, R; Serrano, M
Embo Molecular Medicine
10
(9 )
e9355 -
(2018)
Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing
Parras, A; Anta, H; Santos-Galindo, M; Swarup, V; Elorza, A; Nieto-González, JL; Picó, S; Hernández, IH; Díaz-Hernández, JI; Belloc, E; Rodolosse, A; Parikshak, NN; Peñagarikano, O; Fernández-Chacón, R; Irimia, M; Navarro, P; Geschwind, DH; Méndez, R; Lucas, JJ
Nature
560
(7719 )
441 -
+
(2018)
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Tauriello, DVF; Palomo-Ponce, S; Stork, D; Berenguer-Llergo, A; Badia-Ramentol, J; Iglesias, M; Sevillano, M; Ibiza, S; Cañellas, A; Momblona, XH; Byrom, D; Matarin, JA; Calon, A; Rivas, EI; Nebreda, AR; Riera, A; Attolini, CSO; Batlle, E
Nature
554
(7693 )
538 -
+
(2018)
NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization
Freixo, F; Delgado, PM; Manso, Y; Sánchez-Huertas, C; Lacasa, C; Soriano, E; Roig, J; Lüders, J
Nature Communications
9
(1 )
2330 -
(2018)
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
Cánovas, B; Igea, A; Sartori, AA; Gomis, RR; Paull, TT; Isoda, M; Pérez-Montoyo, H; Serra, V; González-Suárez, E; Stracker, TH; Nebreda, AR
Cancer Cell
33
(6 )
1094 -
+
(2018)
EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation
Silva J; Aivio S; Knobel PA; Bailey LJ; Casali A; Vinaixa M; Garcia-Cao I; Coyaud É; Jourdain AA; Pérez-Ferreros P; Rojas AM; Antolin-Fontes A; Samino-Gené S; Raught B; González-Reyes A; Ribas De Pouplana L; Doherty AJ; Yanes O; Stracker TH
Nature Cell Biology
20
(2 )
162 -
+
(2018)
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+breast cancer
Gawrzak, S; Rinaldi, L; Gregorio, S; Arenas, EJ; Salvador, F; Urosevic, J; Figueras-Puig, C; Rojo, F; Barrantes, ID; Cejalvo, JM; Palafox, M; Guiu, M; Berenguer-Llergo, A; Symeonidi, A; Bellmunt, A; Kalafatovic, D; Arnal-Estapé, A; Fernández, E; Müllauer, B; Groeneveld, R; Slobodnyuk, K; Attolini, CSO; Saura, C; Arribas, J; Cortes, J; Rovira, A; Muñoz, M; Lluch, A; Serra, V; Albanell, J; Prat, A; Nebreda, AR; Benitah, SA; Gomis, RR
Nature Cell Biology
20
(2 )
211 -
+
(2018)
Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing
Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González JL, Picó S Hernández IH, Díaz-Hernández JI, Belloc E, Rodolosse A, Parikshak NN, Peñagarikano O, Fernández-Chacón R, Irimia M, Navarro P, Geschwind DH, Méndez R*, Lucas JJ*. (* co-corresponding authors).
Nature
560
(7719 )
441 -
+
(2018)
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas, G; Peixoto, FO; Perdiguero, E; Jardí, M; Ruiz-Bonilla, V; Datta, D; Symeonidi, A; Castellanos, A; Welz, PS; Caballero, JM; Sassone-Corsi, P; Muñoz-Cánoves, P; Benitah, SA
Cell
170
(4 )
678 -
+
(2017)
Reduced mutation rate in exons due to differential mismatch repair
Frigola, J; Sabarinathan, R; Mularoni, L; Muiños, F; Gonzalez-Perez, A; López-Bigas, N
Nature Genetics
49
(12 )
1684 -
+
(2017)
Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial
Coleman, R; Hall, A; Albanell, J; Hanby, A; Bell, R; Cameron, D; Dodwell, D; Marshall, H; Jean-Mairet, J; Tercero, JC; Rojo, F; Gregory, W; Gomis, RR
Lancet Oncology
18
(11 )
1543 -
1552
(2017)
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment
Testoni, G; Duran, J; García-Rocha, M; Vilaplana, F; Serrano, AL; Sebastián, D; López-Soldado, I; Sullivan, MA; Slebe, F; Vilaseca, M; Muñoz-Cánoves, P; Guinovart, JJ
Cell Metabolism
26
(1 )
256 -
+
(2017)
Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
Barriga, FM; Montagni, E; Mana, M; Mendez-Lago, M; Hernando-Momblona, X; Sevillano, M; Guillaumet-Adkins, A; Rodriguez-Esteban, G; Buczacki, SJA; Gut, M; Heyn, H; Winton, DJ; Yilmaz, OH; Attolini, CSO; Gut, I; Batlle, E
Cell Stem Cell
20
(6 )
801 -
+
(2017)
Targeting metastasis-initiating cells through the fatty acid receptor CD36.
Pascual, G; Avgustinova, A; Mejetta, S; Martín, M; Castellanos, A; Attolini, CSO; Berenguer, A; Prats, N; Toll, A; Hueto, JA; Bescós, C; Di Croce, L; Benitah, SA
Nature
541
(7635 )
41 -
+
(2017)
Nucleotide excision repair is impaired by binding of transcription factors to DNA
Sabarinathan R; Mularoni L; Deu-Pons J; Gonzalez-Perez A; Lopez-Bigas N
Nature
532
(7598 )
264 -
267
(2016)
Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
Salomó, E; Orgué, S; Riera, A; Verdaguer, X
Angewandte Chemie (International Ed. Print)
55
(28 )
7988 -
7992
(2016)
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Calon, A; Lonardo, E; Berenguer-Llergo, A; Espinet, E; Hernando-Momblona, X; Iglesias, M; Sevillano, M; Palomo-Ponce, S; Tauriello, DVF; Byrom, D; Cortina, C; Morral, C; Barceló, C; Tosi, S; Riera, A; Attolini, CSO; Rossell, D; Sancho, E; Batlle, E
Nature Genetics
47
(4 )
320 -
U62
(2015)
Applying the Retro-Enantio Approach To Obtain a Peptide Capable of Overcoming the Blood-Brain Barrier
Prades, Roger; Oller-Salvia, Benjami; Schwarzmaier, Susanne M; Selva, Javier; Moros, Maria; Balbi, Matilde; Grazu, Valeria; de la Fuente, Jesus M; Egea, Gustavo; Plesnila, Nikolaus; Teixido, Meritxell; Giralt, Ernest
Angewandte Chemie (International Ed. Print)
54
(13 )
3967 -
3972
(2015)
Specification of differentiated adult progenitors via inhibition of endocycle entry in the Drosophila trachea
Djabrayan N; Cruz J; de Miguel C; Franch-Marro X; Casanova J
Cell Reports
9
(3 )
859 -
865
(2014)
A Role for tRNA Modifications in Genome Structure and Codon Usage
Novoa, EM; Pavon-Eternod, M; Pan, T; de Pouplana, LR
Cell
149
(1 )
202 -
213
(2012)
Specific GATA Factors Act as Conserved Inducers of an Endodermal-EMT
Campbell, K; Whissell, G; Franch-Marro, X; Batlle, E; Casanova, J
Developmental Cell
21
(6 )
1051 -
1061
(2011)
The circadian molecular clock creates epidermal stem cell heterogeneity
Janich, Peggy; Pascual, Gloria; Merlos-Suarez, Anna; Batlle, Eduard; Ripperger, Juergen; Albrecht, Urs; Cheng, Hai-Ying M; Obrietan, Karl; Di Croce, Luciano; Aznar Benitah, Salvador
Nature
480
(7376 )
209 -
U89
(2011)