Publicaciones institucionales seleccionadas

A new paradigm for molecular dynamics databases: the COVID-19 database, the legacy of a titanic community effort

Beltrán, D; Hospital, A; Gelpi, JL; Orozco, M

NUCLEIC ACIDS RESEARCH,

(D1)

D393

- D403

(2024)

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

Chen, HA; Ho, YJ; Mezzadra, R; Adrover, JM; Smolkin, R; Zhu, CY; Woess, K; Bernstein, N; Schmitt, G; Fong, LD; Luan, W; Wuest, A; Tian, S; Li, X; Broderick, C; Hendrickson, RC; Egeblad, M; Chen, ZH; Alonso-Curbelo, D; Lowe, SW

Cancer Discovery,

(2)

432

- 453

(2023)

MAF amplification licenses ERa through epigenetic remodelling to drive breast cancer metastasis

Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballè, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR

NATURE CELL BIOLOGY,

(12)

1833

- 1847

(2023)

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Marin, I; Boix, O; Garcia-Garijo, A; Sirois, I; Caballe, A; Zarzuela, E; Ruano, I; Attolini, CSO; Prats, N; López-Domínguez, JA; Kovatcheva, M; Garralda, E; Muñoz, J; Caron, E; Abad, M; Gros, A; Pietrocola, F; Serrano, M

Cancer Discovery,

(2)

410

- 431

(2023)

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M

Nature Metabolism,

(11)

1911

- 1930

(2023)

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing

Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M

NATURE CELL BIOLOGY,

(11)

1590

- 1599

(2023)

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L

SCIENCE,

380

(6651)

eadh9351

- eadh9351

(2023)

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA

NATURE AGING,

(6)

688

(2023)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR

Nature Communications,

(1)

3318

(2023)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M

NUCLEIC ACIDS RESEARCH,

(10)

4713

- 4725

(2023)

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D

SCIENCE,

380

(6645)

597

(2023)

López-Güell, K; Battistini, F; Orozco, M

NUCLEIC ACIDS RESEARCH,

(6)

2633

- 2640

(2023)

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress

Fernández-Alfara, M; Sibilio, A; Martin, J; Uxó, ET; Malumbres, M; Alcalde, V; Chanes, V; Cañellas-Socias, A; Palomo-Ponce, S; Batlle, E; Méndez, R

EMBO JOURNAL,

(9)

e111494

(2023)

Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG

Ali, A; Vineethakumari, C; Lacasa, C; Lüders, J

Nature Communications,

(1)

289

(2023)

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis

Domingo-Muelas, A; Duart-Abadia, P; Morante-Redolat, JM; Jordán-Pla, A; Belenguer, G; Fabra-Beser, J; Paniagua-Herranz, L; Pérez-Villalba, A; Alvarez-Varela, A; Barriga, FM; Gil-Sanz, C; Ortega, F; Batlle, E; Fariñas, I

Nature Communications,

(1)

373

(2023)

Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein

Machón, C; Ruiz-Masó, JA; Amodio, J; Boer, DR; Bordanaba-Ruiseco, L; Bury, K; Konieczny, I; del Solar, G; Coll, M

NUCLEIC ACIDS RESEARCH,

(3)

1458

- 1472

(2023)

Hallmarks of aging: An expanding universe

López-Otin, C; Blasco, MA; Partridge, L; Serrano, M; Kroemer, G

CELL,

186

(2)

243

- 278

(2023)

Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

Irazoki, A; Gordaliza-Alaguero, I; Frank, E; Giakoumakis, NN; Seco, J; Palacín, M; Guma, A; Sylow, L; Sebastián, D; Zorzano, A

Nature Communications,

(1)

108

(2023)

Implementing re-configurable biological computation with distributed multicellular consortia

Canadell, D; Ortiz-Vaquerizas, N; Mogas-Diez, S; de Nadal, E; Macia, J; Posas, F

NUCLEIC ACIDS RESEARCH,

(21)

12578

- 12595

(2022)

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X;...

NATURE,

611

(7936)

603

- 613

(2022)

The role of lipids in cancer progression and metastasis

Martin-Perez, M; Urdiroz-Urricelqui, U; Bigas, C; Benitah, SA

Cell Metabolism,

(11)

1675

- 1699

(2022)

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque

Fernández-Torras, A; Duran-Frigola, M; Bertoni, M; Locatelli, M; Aloy, P

Nature Communications,

(1)

5304

(2022)

Discovering the drivers of clonal hematopoiesis

Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N

Nature Communications,

(1)

4267

(2022)

A single WNT enhancer drives specification and regeneration of the Drosophila wing

Gracia-Latorre, E; Pérez, L; Muzzopappa, M; Milán, M

Nature Communications,

(1)

4794

(2022)

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening

Alvarez, MM; Biayna, J; Supek, F

Nature Communications,

(1)

4520

(2022)

The impact of rare germline variants on human somatic mutation processes

Vali-Pour, M; Lehner, B; Supek, F

Nature Communications,

(1)

3724

(2022)

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy

Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E

Nature Cancer,

(9)

1052

(2022)

Mutational signatures are markers of drug sensitivity of cancer cells

Levati, J; Salvadores, M; Fuster-Tormo, F; Supek, F

Nature Communications,

(1)

2926

(2022)

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R;...

Nature Cancer,

(4)

418

(2022)

Overcoming TGF beta-mediated immune evasion in cancer

Tauriello, DVF; Sancho, E; Batlle, E

NATURE REVIEWS CANCER,

(1)

- 44

(2022)

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Pascual, G; Dominguez, D; Elosua-Bayes, M; Beckedorff, F; Laudanna, C; Bigas, C; Douillet, D; Greco, C; Symeonidi, A; Hernandez, I; Gil, SR; Prats, N; Bescos, C; Shiekhattar, R; Amit, M; Heyn, H; Shilatifard, A; Benitah, SA

NATURE,

599

(7885)

485

(2021)

The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA

Vera-Otarola, J; Castillo-Vargas, E; Angulo, J; Barriga, FM; Batlle, E; Lopez-Lastra, M

PLoS Pathogens,

(9)

e1009931

(2021)

In silico saturation mutagenesis of cancer genes

Muiños, F; Martínez-Jiménez, F; Pich, O; Gonzalez-Perez, A; Lopez-Bigas, N

NATURE,

596

(7872)

428

(2021)

Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M

DEVELOPMENTAL CELL,

(14)

2043

(2021)

Bioactivity descriptors for uncharacterized chemical compounds

Bertoni, M; Duran-Frigola, M; Badia-i-Mompel, P; Pauls, E; Orozco-Ruiz, M; Guitart-Pla, O; Alcalde, V; Diaz, VM; Berenguer-Llergo, A; Brun-Heath, I; Villegas, N; de Herreros, AG; Aloy, P

Nature Communications,

(1)

3932

(2021)

Mitochondrial dynamics and liver cancer

Hernández-Alvarez, MI; Zorzano, A

Cancers,

(11)

2571

(2021)

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Rol, A; Todorovski, T; Martin-Malpartida, P; Escolà, A; Gonzalez-Rey, E; Aragón, E; Verdaguer, X; Vallès-Miret, M; Farrera-Sinfreu, J; Puig, E; Fernández-Carneado, J; Ponsati, B; Delgado, M; Riera, A; Macias, MJ

Nature Communications,

(1)

1869

(2021)

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

Pekmezovic, M; Hovhannisyan, H; Gresnigt, MS; Iracane, E; Oliveira-Pacheco, J; Siscar-Lewin, S; Seemann, E; Qualmann, B; Kalkreuter, T; Müller, S; Kamradt, T; Mogavero, S; Brunke, S; Butler, G; Gabaldón, T; Hube, B

Nature Microbiology,

(5)

643

(2021)

Timing the origin of eukaryotic cellular complexity with ancient duplications

Vosseberg, J; van Hooff, JJE; Marcet-Houben, M; van Vlimmeren, A; van Wijk, LM; Gabaldón, T; Snel, B

Nature Ecology & Evolution,

(1)

- 100

(2021)

Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer

Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A

Nature Cancer,

(1)

122

(2020)

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase

Zimmermann, F; Serna, M; Ezquerra, A; Fernandez-Leiro, R; Llorca, O; Luders, J

Science Advances,

(51)

eabe0894

(2020)

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Lynch, CJ; Bernad, R; Martínez-Val, A; Shahbazi, MN; Nóbrega-Pereira, S; Calvo, I; Blanco-Aparicio, C; Tarantino, C; Garreta, E; Richart-Ginés, L; Alcazar, N; Graña-Castro, O; Gómez-Lopez, G; Aksoy, I; Muñoz-Martín, M; Martinez, S; Ortega, S; Prieto, S; Simboeck, E; Camasses, A; Attolini, CSO; Fernandez, AF; Sierra, MI; Fraga, MF; Pastor,...

NATURE CELL BIOLOGY,

(10)

1223

(2020)

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Pittis, AA; Goh, V; Cebrian-Serrano, A; Wettmarshausen, J; Perocchi, F; Gabaldón, T

Nature Communications,

(1)

4031

(2020)

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Mas-Ponte, D; Supek, F