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Research

At the forefront of biomedicine

Institutional selected publications

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X;...
Nature,
611
(7936)
603
- 613
(2022)
The role of lipids in cancer progression and metastasis
Martin-Perez, M; Urdiroz-Urricelqui, U; Bigas, C; Benitah, SA
Cell Metabolism,
34
(11)
1675
- 1699
(2022)
Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque
Fernández-Torras, A; Duran-Frigola, M; Bertoni, M; Locatelli, M; Aloy, P
Nature Communications,
13
(1)
5304
(2022)
Discovering the drivers of clonal hematopoiesis
Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Communications,
13
(1)
4267
(2022)
A single WNT enhancer drives specification and regeneration of the Drosophila wing
Gracia-Latorre, E; Pérez, L; Muzzopappa, M; Milán, M
Nature Communications,
13
(1)
4794
(2022)
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
Alvarez, MM; Biayna, J; Supek, F
Nature Communications,
13
(1)
4520
(2022)
The impact of rare germline variants on human somatic mutation processes
Vali-Pour, M; Lehner, B; Supek, F
Nature Communications,
13
(1)
3724
(2022)
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E
Nature Cancer,
3
(9)
1052
(2022)
Mutational signatures are markers of drug sensitivity of cancer cells
Levati, J; Salvadores, M; Fuster-Tormo, F; Supek, F
Nature Communications,
13
(1)
2926
(2022)
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R;...
Nature Cancer,
3
(4)
418
(2022)
Overcoming TGF beta-mediated immune evasion in cancer
Tauriello, DVF; Sancho, E; Batlle, E
Nature Reviews Cancer,
22
(1)
25
- 44
(2022)
Dietary palmitic acid promotes a prometastatic memory via Schwann cells
Pascual, G; Dominguez, D; Elosua-Bayes, M; Beckedorff, F; Laudanna, C; Bigas, C; Douillet, D; Greco, C; Symeonidi, A; Hernandez, I; Gil, SR; Prats, N; Bescos, C; Shiekhattar, R; Amit, M; Heyn, H; Shilatifard, A; Benitah, SA
Nature,
599
(7885)
485
(2021)
The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA
Vera-Otarola, J; Castillo-Vargas, E; Angulo, J; Barriga, FM; Batlle, E; Lopez-Lastra, M
Plos Pathogens,
17
(9)
e1009931
(2021)
In silico saturation mutagenesis of cancer genes
Muiños, F; Martínez-Jiménez, F; Pich, O; Gonzalez-Perez, A; Lopez-Bigas, N
Nature,
596
(7872)
428
(2021)
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M
Developmental Cell,
56
(14)
2043
(2021)
Bioactivity descriptors for uncharacterized chemical compounds
Bertoni, M; Duran-Frigola, M; Badia-i-Mompel, P; Pauls, E; Orozco-Ruiz, M; Guitart-Pla, O; Alcalde, V; Diaz, VM; Berenguer-Llergo, A; Brun-Heath, I; Villegas, N; de Herreros, AG; Aloy, P
Nature Communications,
12
(1)
3932
(2021)
Mitochondrial dynamics and liver cancer
Hernández-Alvarez, MI; Zorzano, A
Cancers,
13
(11)
2571
(2021)
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
Rol, A; Todorovski, T; Martin-Malpartida, P; Escolà, A; Gonzalez-Rey, E; Aragón, E; Verdaguer, X; Vallès-Miret, M; Farrera-Sinfreu, J; Puig, E; Fernández-Carneado, J; Ponsati, B; Delgado, M; Riera, A; Macias, MJ
Nature Communications,
12
(1)
1869
(2021)
Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells
Pekmezovic, M; Hovhannisyan, H; Gresnigt, MS; Iracane, E; Oliveira-Pacheco, J; Siscar-Lewin, S; Seemann, E; Qualmann, B; Kalkreuter, T; Müller, S; Kamradt, T; Mogavero, S; Brunke, S; Butler, G; Gabaldón, T; Hube, B
Nature Microbiology,
6
(5)
643
(2021)
Timing the origin of eukaryotic cellular complexity with ancient duplications
Vosseberg, J; van Hooff, JJE; Marcet-Houben, M; van Vlimmeren, A; van Wijk, LM; Gabaldón, T; Snel, B
Nature Ecology & Evolution,
5
(1)
(2021)
Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer
Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A
Nature Cancer,
1
(1)
122
(2020)
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase
Zimmermann, F; Serna, M; Ezquerra, A; Fernandez-Leiro, R; Llorca, O; Luders, J
Science Advances,
6
(51)
eabe0894
(2020)
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases
Lynch, CJ; Bernad, R; Martínez-Val, A; Shahbazi, MN; Nóbrega-Pereira, S; Calvo, I; Blanco-Aparicio, C; Tarantino, C; Garreta, E; Richart-Ginés, L; Alcazar, N; Graña-Castro, O; Gómez-Lopez, G; Aksoy, I; Muñoz-Martín, M; Martinez, S; Ortega, S; Prieto, S; Simboeck, E; Camasses, A; Attolini, CSO; Fernandez, AF; Sierra, MI; Fraga, MF; Pastor,...
Nature Cell Biology,
22
(10)
1223
(2020)
Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
Pittis, AA; Goh, V; Cebrian-Serrano, A; Wettmarshausen, J; Perocchi, F; Gabaldón, T
Nature Communications,
11
(1)
4031
(2020)
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Mas-Ponte, D; Supek, F
Nature Genetics,
52
(9)
958
(2020)
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P
Nature Biotechnology,
38
(9)
1087
(2020)
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral, C; Stanisavljevic, J; Hernando-Momblona, X; Mereu, E; Alvarez-Varela, A; Cortina, C; Stork, D; Slebe, F; Turon, G; Whissell, G; Sevillano, M; Merlos-Suárez, A; Casanova-Martí, A; Moutinho, C; Lowe, SW; Dow, LE; Villanueva, A; Sancho, E; Heyn, H; Batlle, E
Cell Stem Cell,
26
(6)
845
(2020)
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Pascual, R; Martín, J; Salvador, F; Reina, O; Chanes, V; Millanes-Romero, A; Suñer, C; Fernández-Miranda, G; Bartomeu, A; Huang, YS; Gomis, RR; Méndez, R
Science Advances,
6
(20)
eaax3868
(2020)
Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols
Cabre, A; Rafael, S; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A
Angewandte Chemie (International Ed. Print),
59
(19)
7521
- 7527
(2020)
Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio, L; Milán, M
Developmental Cell,
52
(5)
659
(2020)
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Hernández-Alvarez, MI; Sebastián, D; Vives, S; Ivanova, S; Bartoccioni, P; Kakimoto, P; Plana, N; Veiga, SR; Hernández, V; Vasconcelos, N; Peddinti, G; Adrover, A; Jové, M; Pamplona, R; Gordaliza-Alaguero, I; Calvo, E; Cabré, N; Castro, R; Kuzmanic, A; Boutant, M; Sala, D; Hyotylainen, T; Oresic, M; Fort, J; Errasti-Murugarren, E;...
Cell,
177
(4)
881
(2019)
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh, B; Banduseela, VC; Chiesa, G; Martínez-Cristóbal, P; Rauch, JN; Nath, SR; Schwarz, DMC; Shao, H; Marin-Argany, M; Di Sanza, C; Giorgetti, E; Yu, ZG; Pieratelli, R; Felli, IC; Brun-Heath, I; García, J; Nebreda, AR; Gestwicki, JE; Lieberman, AP; Salvatella, X
Nature Communications,
10
(1)
3562
(2019)
Evolutionary and functional patterns of shared gene neighbourhood in fungi
Marcet-Houben, M; Gabaldón, T
Nature Microbiology,
4
(12)
2383
- 2392
(2019)
The mutational footprints of cancer therapies
Pich, O; Muiños, F; Lolkema, MP; Steeghs, N; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Genetics,
51
(12)
1732
(2019)
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Lindeboom, RGH; Vermeulen, M; Lehner, B; Supek, F
Nature Genetics,
51
(11)
1645
(2019)
Atomic structure of the Epstein-Barr virus portal
Machón, C; Fàbrega-Ferrer, M; Zhou, DM; Cuervo, A; Carrascosa, JL; Stuart, DI; Coll, M
Nature Communications,
10
(1)
3891
(2019)
Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
Cuervo, A; Fàbrega-Ferrer, M; Machón, C; Conesa, JJ; Fernández, FJ; Pérez-Luque, R; Pérez-Ruiz, M; Pous, J; Vega, MC; Carrascosa, JL; Coll, M
Nature Communications,
10
(1)
3746
(2019)
An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases
Aranda, J; Terrazas, M; Gómez, H; Villegas, N; Orozco, M
Nature Catalysis,
2
(6)
544
- 552
(2019)
The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry
Terrazas, M; Genna, V; Portella, G; Villegas, N; Sánchez, D; Arnan, C; Pulido-Quetglas, C; Johnson, R; Guigó, R; Brun-Heath, I; Aviñó, A; Eritja, R; Orozco, M
Chem,
5
(6)
1619
- 1631
(2019)
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo, A; Topal, B; Kunze, MBA; Aranda, J; Chiesa, G; Mungianu, D; Bernardo-Seisdedos, G; Eftekharzadeh, B; Gairí, M; Pierattelli, R; Felli, IC; Diercks, T; Millet, O; García, J; Orozco, M; Crehuet, R; Lindorff-Larsen, K; Salvatella, X
Nature Communications,
10
(1)
2034
(2019)
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Errasti-Murugarren, E; Fort, J; Bartoccioni, P; Díaz, L; Pardon, E; Carpena, X; Espino-Guarch, M; Zorzano, A; Ziegler, C; Steyaert, J; Fernández-Recio, J; Fita, I; Palacín, M
Nature Communications,
10
1807
(2019)
Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit
Picchioni, D; Antolin-Fontes, A; Camacho, N; Schmitz, C; Pons-Pons, A; Rodríguez-Escribà, M; Machallekidou, A; Güler, MN; Siatra, P; Carretero-Junquera, M; Serrano, A; Hovde, SL; Knobel, PA; Novoa, EM; Solà-Vilarrubias, M; Kaguni, LS; Stracker, TH; de Pouplana, LR
Cell Reports,
27
(1)
40
(2019)
An In-Depth Look at DNA Crystals through the Prism of Molecular Dynamics Simulations
Kuzmanic, A; Dans, PD; Orozco, M
Chem,
5
(3)
649
- 663
(2019)
Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues
Benhra, N; Barrio, L; Muzzopappa, M; Milán, M
Developmental Cell,
47
(2)
161
(2018)
Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes
Pich, O; Muiños, F; Sabarinathan, R; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N
Cell,
175
(4)
1074
(2018)