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Investigación

A la vanguardia de la biomedicina

Publicaciones sobre Investigación

Intrinsically disordered proteins and biomolecular condensates as drug targets
Biesaga, M; Frigolé-Vivas, M; Salvatella, X
Current Opinion In Chemical Biology
62
90 -
100
2021-06-01
Impact of DNA methylation on 3D genome structure
Buitrago, D; Labrador, M; Arcon, JP; Lema, R; Flores, O; Esteve-Codina, A; Blanc, J; Villegas, N; Bellido, D; Gut, M; Dans, PD; Heath, SC; Gut, IG; Heath, IB; Orozco, M
Nature Communications
12
1
3243 -
2021-05-28
Quality control of protein reagents for the improvement of research data reproducibility
de Marco, A; Berrow, N; Lebendiker, M; Garcia-Alai, M; Knauer, SH; Lopez-Mendez, B; Matagne, A; Parret, A; Remans, K; Uebel, S; Raynal, B
Nature Communications
12
1
2795 -
2021-05-14
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo
Climent-Cantó, P; Carbonell, A; Tamirisa, S; Henn, L; Pérez-Montero, S; Boros, IM; Azorín, F
Open Biology
11
5
200408 -
2021-05-05
Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells
Pekmezovic, M; Hovhannisyan, H; Gresnigt, MS; Iracane, E; Oliveira-Pacheco, J; Siscar-Lewin, S; Seemann, E; Qualmann, B; Kalkreuter, T; Müller, S; Kamradt, T; Mogavero, S; Brunke, S; Butler, G; Gabaldón, T; Hube, B
Nature Microbiology
6
5
643 -
2021-05-01
Diversity and versatility of p38 kinase signalling in health and disease
Canovas, B; Nebreda, AR
Nature Reviews Molecular Cell Biology
22
5
346 -
366
2021-05-01
The Upd3 cytokine couples inflammation to maturation defects in Drosophila
Romao, D; Muzzopappa, M; Barrio, L; Milan, M
Current Biology
31
8
1780 -
2021-04-26
Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19
Bernad, R; Lynch, CJ; Urdinguio, RG; Attolini, CSO; Fraga, MF; Serrano, M
Cells
10
4
876 -
2021-04-01
Regulation of biomolecular condensate dynamics by signaling
Garcia-Cabau, C; Salvatella, X
Current Opinion In Cell Biology
69
111 -
119
2021-04-01
Dissection of two routes to naive pluripotency using different kinase inhibitors
Martinez-Val, A; Lynch, CJ; Calvo, I; Ximenez-Embun, P; Garcia, F; Zarzuela, E; Serrano, M; Munoz, J
Nature Communications
12
1
1863 -
2021-03-25
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
Rol, A; Todorovski, T; Martin-Malpartida, P; Escolà, A; Gonzalez-Rey, E; Aragón, E; Verdaguer, X; Vallès-Miret, M; Farrera-Sinfreu, J; Puig, E; Fernández-Carneado, J; Ponsati, B; Delgado, M; Riera, A; Macias, MJ
Nature Communications
12
1
1869 -
2021-03-25
AutoScanJ: A Suite of ImageJ Scripts for Intelligent Microscopy
Tosi, S; Lladó, A; Bardia, L; Rebollo, E; Godo, A; Stockinger, P; Colombelli, J
Frontiers In Bioinformatics
1
627626 -
2021-03-18
Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins
Freier, R; Aragon, E; Pluta, R; Martin-Malpartida, P; Ruiz, L; Condeminas, M; Gonzalez, C; Macias, MJ
Iucrj
8
Pt 2
281 -
294
2021-03-01
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
Biayna, J; Garcia-Cao, I; Alvarez, MM; Salvadores, M; Espinosa-Carrasco, J; McCullough, M; Supek, F; Stracker, TH
Plos Biology
19
3
e3001176 -
2021-03-01
Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells
Giannios, P; Casanova, J
Plos Genetics
17
2
e1009362 -
2021-02-01
Centrosomes in asymmetric cell division
Gonzalez, C
Current Opinion In Structural Biology
66
178 -
182
2021-02-01
Conformational landscape of multidomain SMAD proteins
Gomes, T; Martin-Malpartida, P; Ruiz, L; Aragón, E; Cordeiro, TN; Macias, MJ
Computational And Structural Biotechnology Journal
19
5210 -
5224
2021-01-01
MosaicExplorerJ: Interactive stitching of terabyte-size tiled datasets from lightsheet microscopy
Tosi S; Bardia L; Barallobre MJ; Muñoz-Barrutia A; Soto-Montenegro ML; Colombelli J
F1000research
9
1 -
15
2021-01-01
Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
Ruiz, L; Kaczmarska, Z; Gomes, T; Aragon, E; Torner, C; Freier, R; Baginski, B; Martin-Malpartida, P; Garrido, ND; Marquez, JA; Cordeiro, TN; Pluta, R; Macias, MJ
Computational And Structural Biotechnology Journal
19
632 -
646
2021-01-01
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
Bauer S, Heinrich MC, George S, Zalcberg JR, Serrano C, Gelderblom H, Jones RL, Attia S, D’Amato G, Chi P, Reichardt P, Meade J, Su Y, Ruiz-Soto R, Blay JY,
von Mehren M, Schöffski P.
Clin Cancer Res
6333 -
6342
2021
E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor
Alfonso García-Valverde, Jordi Rosell, Sergi Sayols, David Gómez-Peregrina, Daniel F Pilco-Janeta, Iván Olivares-Rivas, Enrique de Álava, Joan Maurel, Jordi Rubió-Casadevall, Anna Esteve, Marta Gut, Claudia Valverde, Jordi Barretina, Joan Carles, George D Demetri, Jonathan A Fletcher, Joaquín Arribas & César Serrano
Oncogene
2021
A gene–environment-induced epigenetic program initiates tumorigenesis
Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan L, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW.
Nature
2021
The evolution of relapse of adult T cell acute lymphoblastic leukemia
Sentís, I; Gonzalez, S; Genescà, E; García-Hernández, V; Muiños, F; Gonzalez, C; López-Arribillaga, E; Gonzalez, J; Fernandez-Ibarrondo, L; Mularoni, L; Espinosa, L; Bellosillo, B; Ribera, JM; Bigas, A; Gonzalez-Perez, A; Lopez-Bigas, N
Genome Biology
21
1
284 -
2020-12-23
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase
Zimmermann, F; Serna, M; Ezquerra, A; Fernandez-Leiro, R; Llorca, O; Luders, J
Science Advances
6
51
eabe0894 -
2020-12-01
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing
Sun-Wang, JL; Ivanova, S; Zorzano, A
Ageing Research Reviews
64
101203 -
2020-12-01
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice
Rodríguez-Matellán, A; Alcazar, N; Hernández, F; Serrano, M; Avila, J
Stem Cell Reports
15
5
1056 -
1066
2020-11-10
Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand
Martinez-Crespo, Luis; Liang Sun-Wang, Jia; Felipe Sierra, Andres; Aragay, Gemma; Errasti-Murugarren, Ekaitz; Bartoccioni, Paola; Palacin, Manuel; Ballester, P
Chem
6
11
3054 -
3070
2020-11-05
Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome
Testoni, G; Olmeda, B; Duran, J; López-Rodríguez, E; Aguilera, M; Hernández-Alvarez, MI; Prats, N; Pérez-Gil, J; Guinovart, JJ
Human Molecular Genetics
29
21
3554 -
3565
2020-11-01
ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer
Urosevic, J; Blasco, MT; Llorente, A; Bellmunt, A; Berenguer-Llergo, A; Guiu, M; Cañellas, A; Fernandez, E; Burkov, I; Clapés, M; Cartanà, M; Figueras-Puig, C; Batlle, E; Nebreda, AR; Gomis, RR
Cancer Research
80
21
4668 -
4680
2020-11-01
Manipulating the Mediator complex to induce naïve pluripotency
Lynch, CJ; Bernad, R; Calvo, I; Serrano, M
Experimental Cell Research
395
2
112215 -
2020-10-15
A compendium of mutational cancer driver genes
Martínez-Jiménez, F; Muiños, F; Sentís, I; Deu-Pons, J; Reyes-Salazar, I; Arnedo-Pac, C; Mularoni, L; Pich, O; Bonet, J; Kranas, H; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Reviews Cancer
20
10
555 -
572
2020-10-01
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Mateo, L; Duran-Frigola, M; Gris-Oliver, A; Palafox, M; Scaltriti, M; Razavi, P; Chandarlapaty, S; Arribas, J; Bellet, M; Serra, V; Aloy, P
Genome Medicine
12
1
78 -
2020-09-09
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Mas-Ponte, D; Supek, F
Nature Genetics
52
9
958 -
2020-09-01
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
Donoghue, C; Cubillos-Rojas, M; Gutierrez-Prat, N; Sanchez-Zarzalejo, C; Verdaguer, X; Riera, A; Nebreda, AR
European Journal Of Medicinal Chemistry
201
112451 -
2020-09-01
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P
Nature Biotechnology
38
9
1087 -
2020-09-01
A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression
Torras-Llort, M; Medina-Giró, S; Escudero-Ferruz, P; Lipinszki, Z; Moreno-Moreno, O; Karman, Z; Przewloka, MR; Azorín, F
Commun Biol
3
1
454 -
2020-08-19
Self-Eating for Muscle Fitness: Autophagy in the Control of Energy Metabolism
Sebastián, D; Zorzano, A
Developmental Cell
54
2
268 -
281
2020-07-20
Induction of lysosome membrane permeabilization as a therapeutic strategy to target pancreatic cancer stem cells
Cash, TP; Alcalá, S; Rico-Ferreira, MD; Hernández-Encinas, E; García, J; Albarrán, MI; Valle, S; Muñoz, J; Martínez-González, S; Blanco-Aparicio, C; Pastor, J; Serrano, M; Sainz, B
Cancers
12
7
1790 -
2020-07-01
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
Salvadores, M; Fuster-Tormo, F; Supek, F
Science Advances
6
27
eaba1862 -
2020-07-01
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer
Dziubanska-Kusibab, PJ; Berger, H; Battistini, F; Bouwman, BAM; Iftekhar, A; Katainen, R; Cajuso, T; Crosetto, N; Orozco, M; Aaltonen, LA; Meyer, TF
Nature Medicine
26
7
1063 -
2020-07-01
The mitochondrial tRNA conundrum
de Pouplana, LR
Nature Reviews Molecular Cell Biology
21
7
361 -
361
2020-07-01
Circadian Regulation of Adult Stem Cell Homeostasis and Aging
Benitah, SA; Welz, PS
Cell Stem Cell
26
6
817 -
831
2020-06-04
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral, C; Stanisavljevic, J; Hernando-Momblona, X; Mereu, E; Alvarez-Varela, A; Cortina, C; Stork, D; Slebe, F; Turon, G; Whissell, G; Sevillano, M; Merlos-Suárez, A; Casanova-Martí, A; Moutinho, C; Lowe, SW; Dow, LE; Villanueva, A; Sancho, E; Heyn, H; Batlle, E
Cell Stem Cell
26
6
845 -
2020-06-04
GoldenBac: a simple, highly efficient, and widely applicable system for construction of multi-gene expression vectors for use with the baculovirus expression vector system
Neuhold, J; Radakovics, K; Lehner, A; Weissmann, F; Garcia, MQ; Romero, MC; Berrow, NS; Stolt-Bergner, P
Bmc Biotechnology
20
26 -
2020-05-12
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Sati, S; Bonev, B; Szabo, Q; Jost, D; Bensadoun, P; Serra, F; Loubiere, V; Papadopoulos, GL; Rivera-Mulia, JC; Fritsch, L; Bouret, P; Castillo, D; Gelpi, JLI; Orozco, M; Vaillant, C; Pellestor, F; Bantignies, F; Marti-Renom, MA; Gilbert, DM; Lemaitre, JM; Cavalli, G
Molecular Cell
78
3
522 -
2020-05-07
The embryonic linker histone dBigH1 alters the functional state of active chromatin
Climent-Cantó, P; Carbonell, A; Tatarski, M; Reina, O; Bujosa, P; Font-Mateu, J; Bernués, J; Beato, M; Azorín, F
Nucleic Acids Research
48
8
4147 -
4160
2020-05-07
Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols
Cabre, A; Rafael, S; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A
Angewandte Chemie (International Ed. Print)
59
19
7521 -
7527
2020-05-04
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Pascual, R; Martín, J; Salvador, F; Reina, O; Chanes, V; Millanes-Romero, A; Suñer, C; Fernández-Miranda, G; Bartomeu, A; Huang, YS; Gomis, RR; Méndez, R
Science Advances
6
20
eaax3868 -
2020-05-01