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Investigación

A la vanguardia de la biomedicina

Publicaciones sobre Investigación

Furan warheads for covalent trapping of weak protein-protein interactions: cross-linking of thymosin beta 4 to actin
Miret-Casals L; Vannecke W; Hoogewijs K; Arauz-Garofalo G; Gay M; Díaz-Lobo M; Vilaseca M; Ampe C; Van Troys M; Madder A
Chemical Communications
57
49
6054 -
6057
2021
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo
Climent-Cantó P; Carbonell A; Tamirisa S; Henn L; Pérez-Montero S; Boros IM; Azorín F
Open Biology
11
5
200408 -
2021
Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19
Bernad R; Lynch CJ; Urdinguio RG; Stephan-Otto Attolini C; Fraga MF; Serrano M
Cells
10
4
876 -
2021
Quality control of protein reagents for the improvement of research data reproducibility
de Marco A, Berrow N, Lebendiker M, Garcia-Alai M, Knauer SH, Lopez-Mendez B, Matagne A, Parret A, Remans K, Uebel S, Raynal B
Nature Communications
12
1
2795 -
2795
2021
Intrinsically disordered proteins and biomolecular condensates as drug targets
Biesaga M; Frigolé-Vivas M; Salvatella X
Current Opinion In Chemical Biology
62
90 -
100
2021
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
Biayna J; Garcia-Cao I; Álvarez MM; Salvadores M; Espinosa-Carrasco J; McCullough M; Supek F; Stracker TH
Plos Biology
19
3
e3001176 -
2021
The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
Yero D; Díaz-Lobo M; Costenaro L; Conchillo-Solé O; Mayo A; Ferrer-Navarro M; Vilaseca M; Gibert I; Daura X
Commun Biol
4
1
448 -
2021
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
Rol Á; Todorovski T; Martin-Malpartida P; Escolà A; Gonzalez-Rey E; Aragón E; Verdaguer X; Vallès-Miret M; Farrera-Sinfreu J; Puig E; Fernández-Carneado J; Ponsati B; Delgado M; Riera A; Macias MJ
Nature Communications
12
1
1869 -
2021
Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin
Dekan Z; Kremsmayr T; Keov P; Godin M; Teakle N; Dürrauer L; Xiang H; Gharib D; Bergmayr C; Hellinger R; Gay M; Vilaseca M; Kurzbach D; Albericio F; Alewood PF; Gruber CW; Muttenthaler M
Chemical Science
12
11
4057 -
4062
2021
Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells
Pekmezovic M; Hovhannisyan H; Gresnigt MS; Iracane E; Oliveira-Pacheco J; Siscar-Lewin S; Seemann E; Qualmann B; Kalkreuter T; Müller S; Kamradt T; Mogavero S; Brunke S; Butler G; Gabaldón T; Hube B
Nature Microbiology
6
5
643 -
+
2021
Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells
Giannios P; Casanova J
Plos Genetics
17
2
e1009362 -
2021
MosaicExplorerJ: Interactive stitching of terabyte-size tiled datasets from lightsheet microscopy
Tosi S; Bardia L; Barallobre MJ; Muñoz-Barrutia A; Soto-Montenegro ML; Colombelli J
F1000research
9
1 -
15
2021
Regulation of biomolecular condensate dynamics by signaling
Garcia-Cabau C; Salvatella X
Current Opinion In Cell Biology
69
111 -
119
2021
Diversity and versatility of p38 kinase signalling in health and disease
Canovas B; Nebreda AR
Nature Reviews Molecular Cell Biology
22
5
346 -
366
2021
Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
Ruiz L; Kaczmarska Z; Gomes T; Aragon E; Torner C; Freier R; Baginski B; Martin-Malpartida P; de Martin Garrido N; Marquez JA; Cordeiro TN; Pluta R; Macias MJ
Computational And Structural Biotechnology Journal
19
632 -
646
2021
Centrosomes in asymmetric cell division
Gonzalez C
Current Opinion In Structural Biology
66
178 -
182
2021
Timing the origin of eukaryotic cellular complexity with ancient duplications
Vosseberg J; van Hooff JJE; Marcet-Houben M; van Vlimmeren A; van Wijk LM; Gabaldón T; Snel B
Nature Ecology & Evolution
5
1
92 -
100
2021
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
Bauer S, Heinrich MC, George S, Zalcberg JR, Serrano C, Gelderblom H, Jones RL, Attia S, D’Amato G, Chi P, Reichardt P, Meade J, Su Y, Ruiz-Soto R, Blay JY,
von Mehren M, Schöffski P.
Clin Cancer Res
6333 -
6342
2021
E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor
Alfonso García-Valverde, Jordi Rosell, Sergi Sayols, David Gómez-Peregrina, Daniel F Pilco-Janeta, Iván Olivares-Rivas, Enrique de Álava, Joan Maurel, Jordi Rubió-Casadevall, Anna Esteve, Marta Gut, Claudia Valverde, Jordi Barretina, Joan Carles, George D Demetri, Jonathan A Fletcher, Joaquín Arribas & César Serrano
Oncogene
2021
Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development
Alexandra Avgustinova, Carmelo Laudanna, Mónica Pascual-García, Quirze Rovira, Magdolna Djurec, Andres Castellanos, Uxue Urdiroz-Urricelqui, Domenica Marchese, Neus Prats, Alexandra Van Keymeulen, Holger Heyn, Juan M. Vaquerizas, Salvador Aznar Benitah
Cell Stem Cell
7;28(10
1790 -
1804
2021
Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata
Ewa Ksiezopolska, Miquel Àngel Schikora-Tamarit, Reinhard Beyer, Juan Carlos Nunez-Rodriguez, Christoph Schüller, Toni Gabaldón
Current Biology
31.23
5314 -
5326
2021
Dietary palmitic acid promotes a prometastatic memory via Schwann cells
Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I, Gil SR, Prats N, Bescós C, Shiekhattar R, Amit M, Heyn H, Shilatifard A, Benitah SA
Nature
599
485 -
490
2021
A gene–environment-induced epigenetic program initiates tumorigenesis
Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan L, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW.
Nature
2021
Circadian Regulation of Adult Stem Cell Homeostasis and Aging
Benitah, SA; Welz, PS
Cell Stem Cell
26
6
817 -
831
2020
BIAFLOWS: A Collaborative Framework to Reproducibly Deploy and Benchmark Bioimage Analysis Workflows
Rubens, U; Mormont, R; Paavolainen, L; Backer, V; Pavie, B; Scholz, LA; Michiels, G; Maska, M; Unay, D; Ball, G; Hoyoux, R; Vandaele, R; Golani, O; Stanciu, SG; Sladoje, N; Paul-Gilloteaux, P; Maree, R; Tosi, S
Patterns
1
3
100040 -
2020
Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer
Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A
Nature Cancer
1
1
122 -
+
2020
Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome
Testoni G; Olmeda B; Duran J; López-Rodríguez E; Aguilera M; Hernández-Álvarez MI; Prats N; Pérez-Gil J; Guinovart JJ
Human Molecular Genetics
29
21
3554 -
3565
2020
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase
Zimmermann F; Serna M; Ezquerra A; Fernandez-Leiro R; Llorca O; Luders J
Science Advances
6
51
eabe0894 -
2020
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice
Rodríguez-Matellán A; Alcazar N; Hernández F; Serrano M; Ávila J
Stem Cell Reports
15
5
1056 -
1066
2020
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing
Sun-Wang JL; Ivanova S; Zorzano A
Ageing Research Reviews
64
101203
101203 -
2020
Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand
Martínez-Crespo L; Sun-Wang JL; Sierra AF; Aragay G; Errasti-Murugarren E; Bartoccioni P; Palacín M; Ballester P
Chem
6
11
3054 -
3070
2020
A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression
Torras-Llort, Monica; Medina-Giro, Sonia; Escudero-Ferruz, Paula; Lipinszki, Zoltan; Moreno-Moreno, Olga; Karman, Zoltan; Przewloka, Marcin R.; Azorin, Fernando;
Commun Biol
3
1
454 -
2020
The evolution of relapse of adult T cell acute lymphoblastic leukemia
Sentis, Ines; Gonzalez, Santiago; Genesca, Eulalia; Garcia-Hernandez, Violeta; Muinos, Ferran; Gonzalez, Celia; Lopez-Arribillaga, Erika; Gonzalez, Jessica; Fernandez-Ibarrondo, Lierni; Mularoni, Loris; Espinosa, Lluis; Bellosillo, Beatriz; Ribera, Josep-Maria; Bigas, Anna; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria;
Genome Biology
21
1
284 -
2020
ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer
Urosevic, Jelena; Teresa Blasco, Maria; Llorente, Alicia; Bellmunt, Anna; Berenguer-Llergo, Antoni; Guiu, Marc; Canellas, Adria; Fernandez, Esther; Burkov, Ivan; Clapes, Maria; Cartana, Mireia; Figueras-Puig, Cristina; Batlle, Eduard; Nebreda, Angel R.; Gomis, Roger R.;
Cancer Research
80
21
4668 -
4680
2020
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Mateo L; Duran-Frigola M; Gris-Oliver A; Palafox M; Scaltriti M; Razavi P; Chandarlapaty S; Arribas J; Bellet M; Serra V; Aloy P
Genome Medicine
12
1
78 -
2020
Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
Pittis AA; Goh V; Cebrian-Serrano A; Wettmarshausen J; Perocchi F; Gabaldón T
Nature Communications
11
1
4031 -
2020
A compendium of mutational cancer driver genes
Martínez-Jiménez F; Muiños F; Sentís I; Deu-Pons J; Reyes-Salazar I; Arnedo-Pac C; Mularoni L; Pich O; Bonet J; Kranas H; Gonzalez-Perez A; Lopez-Bigas N
Nature Reviews Cancer
20
10
555 -
572
2020
Manipulating the Mediator complex to induce naïve pluripotency
Lynch CJ; Bernad R; Calvo I; Serrano M
Experimental Cell Research
395
2
112215 -
2020
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Mas-Ponte D; Supek F
Nature Genetics
52
9
958 -
+
2020
Induction of lysosome membrane permeabilization as a therapeutic strategy to target pancreatic cancer stem cells
Cash TP; Alcalá S; Rico-Ferreira MDR; Hernández-Encinas E; García J; Albarrán MI; Valle S; Muñoz J; Martínez-González S; Blanco-Aparicio C; Pastor J; Serrano M; Sainz B
Cancers
12
7
1790 -
25
2020
Probing the Kinetic and Thermodynamic Fingerprints of Anti-EGF Nanobodies by Surface Plasmon Resonance
Guardiola, Salvador; Varese, Monica; Taules, Marta; Diaz-Lobo, Mireia; Garcia, Jesus; Giralt, Ernest;
Pharmaceuticals
13
6
134 -
10
2020
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
Salvadores, Marina; Fuster-Tormo, Francisco; Supek, Fran
Science Advances
6
27
eaba1862 -
2020
Self-Eating for Muscle Fitness: Autophagy in the Control of Energy Metabolism
Sebastián D; Zorzano A
Developmental Cell
54
2
268 -
281
2020
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
Donoghue C; Cubillos-Rojas M; Gutierrez-Prat N; Sanchez-Zarzalejo C; Verdaguer X; Riera A; Nebreda AR
European Journal Of Medicinal Chemistry
201
112451
112451 -
2020
The NEUBIAS Gateway: A hub for bioimage analysis methods and materials
Miura K; Cimini BA; Nørrelykke SF; Louveaux M; Sladoje N; Paul-Gilloteaux P; Colombelli J
F1000research
9
613 -
2020
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer
Dziubańska-Kusibab PJ; Berger H; Battistini F; Bouwman BAM; Iftekhar A; Katainen R; Cajuso T; Crosetto N; Orozco M; Aaltonen LA; Meyer TF
Nature Medicine
26
7
1063 -
+
2020
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P
Nature Biotechnology
38
9
1087 -
+
2020
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral C; Stanisavljevic J; Hernando-Momblona X; Mereu E; Álvarez-Varela A; Cortina C; Stork D; Slebe F; Turon G; Whissell G; Sevillano M; Merlos-Suárez A; Casanova-Martí À; Moutinho C; Lowe SW; Dow LE; Villanueva A; Sancho E; Heyn H; Batlle E
Cell Stem Cell
26
6
845 -
+
2020