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Research

At the forefront of biomedicine

Research publications

Intrinsically disordered proteins and biomolecular condensates as drug targets
Biesaga, M; Frigolé-Vivas, M; Salvatella, X
Current Opinion In Chemical Biology
62
-
90 -
100
2021
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
Biayna, J; Garcia-Cao, I; Alvarez, MM; Salvadores, M; Espinosa-Carrasco, J; McCullough, M; Supek, F; Stracker, TH
Plos Biology
19
3
e3001176 -
-
2021
The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
Yero, D; Díaz-Lobo, M; Costenaro, L; Conchillo-Solé, O; Mayo, A; Ferrer-Navarro, M; Vilaseca, M; Gibert, I; Daura, X
Commun Biol
4
1
448 -
-
2021
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
Rol, A; Todorovski, T; Martin-Malpartida, P; Escolà, A; Gonzalez-Rey, E; Aragón, E; Verdaguer, X; Vallès-Miret, M; Farrera-Sinfreu, J; Puig, E; Fernández-Carneado, J; Ponsati, B; Delgado, M; Riera, A; Macias, MJ
Nature Communications
12
1
1869 -
-
2021
Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin
Dekan, Z; Kremsmayr, T; Keov, P; Godin, M; Teakle, N; Dürrauer, L; Xiang, H; Gharib, D; Bergmayr, C; Hellinger, R; Gay, M; Vilaseca, M; Kurzbach, D; Albericio, F; Alewood, PF; Gruber, CW; Muttenthaler, M
Chemical Science
12
11
4057 -
4062
2021
Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells
Pekmezovic, M; Hovhannisyan, H; Gresnigt, MS; Iracane, E; Oliveira-Pacheco, J; Siscar-Lewin, S; Seemann, E; Qualmann, B; Kalkreuter, T; Müller, S; Kamradt, T; Mogavero, S; Brunke, S; Butler, G; Gabaldón, T; Hube, B
Nature Microbiology
6
5
643 -
+
2021
Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells
Giannios, P; Casanova, J
Plos Genetics
17
2
e1009362 -
-
2021
MosaicExplorerJ: Interactive stitching of terabyte-size tiled datasets from lightsheet microscopy
Tosi S; Bardia L; Barallobre MJ; Muñoz-Barrutia A; Soto-Montenegro ML; Colombelli J
F1000research
9
-
1 -
15
2021
Regulation of biomolecular condensate dynamics by signaling
Garcia-Cabau, C; Salvatella, X
Current Opinion In Cell Biology
69
-
111 -
119
2021
Diversity and versatility of p38 kinase signalling in health and disease
Canovas, B; Nebreda, AR
Nature Reviews Molecular Cell Biology
22
5
346 -
366
2021
Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
Ruiz, L; Kaczmarska, Z; Gomes, T; Aragon, E; Torner, C; Freier, R; Baginski, B; Martin-Malpartida, P; Garrido, ND; Marquez, JA; Cordeiro, TN; Pluta, R; Macias, MJ
Computational And Structural Biotechnology Journal
19
-
632 -
646
2021
Centrosomes in asymmetric cell division
Gonzalez, C
Current Opinion In Structural Biology
66
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178 -
182
2021
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
Bauer S, Heinrich MC, George S, Zalcberg JR, Serrano C, Gelderblom H, Jones RL, Attia S, D’Amato G, Chi P, Reichardt P, Meade J, Su Y, Ruiz-Soto R, Blay JY,
von Mehren M, Schöffski P.
Clin Cancer Res
6333 -
6342
2021
E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor
Alfonso García-Valverde, Jordi Rosell, Sergi Sayols, David Gómez-Peregrina, Daniel F Pilco-Janeta, Iván Olivares-Rivas, Enrique de Álava, Joan Maurel, Jordi Rubió-Casadevall, Anna Esteve, Marta Gut, Claudia Valverde, Jordi Barretina, Joan Carles, George D Demetri, Jonathan A Fletcher, Joaquín Arribas & César Serrano
Oncogene
2021
A gene–environment-induced epigenetic program initiates tumorigenesis
Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan L, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW.
Nature
2021
Circadian Regulation of Adult Stem Cell Homeostasis and Aging
Benitah, SA; Welz, PS
Cell Stem Cell
26
6
817 -
831
2020
Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer
Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A
Nature Cancer
1
1
122 -
+
2020
Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome
Testoni, G; Olmeda, B; Duran, J; López-Rodríguez, E; Aguilera, M; Hernández-Alvarez, MI; Prats, N; Pérez-Gil, J; Guinovart, JJ
Human Molecular Genetics
29
21
3554 -
3565
2020
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase
Zimmermann, F; Serna, M; Ezquerra, A; Fernandez-Leiro, R; Llorca, O; Luders, J
Science Advances
6
51
eabe0894 -
-
2020
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice
Rodríguez-Matellán, A; Alcazar, N; Hernández, F; Serrano, M; Avila, J
Stem Cell Reports
15
5
1056 -
1066
2020
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing
Sun-Wang, JL; Ivanova, S; Zorzano, A
Ageing Research Reviews
64
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101203 -
-
2020
Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand
Martinez-Crespo, Luis; Liang Sun-Wang, Jia; Felipe Sierra, Andres; Aragay, Gemma; Errasti-Murugarren, Ekaitz; Bartoccioni, Paola; Palacin, Manuel; Ballester, P
Chem
6
11
3054 -
3070
2020
A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression
Torras-Llort, M; Medina-Giró, S; Escudero-Ferruz, P; Lipinszki, Z; Moreno-Moreno, O; Karman, Z; Przewloka, MR; Azorín, F
Commun Biol
3
1
454 -
-
2020
The evolution of relapse of adult T cell acute lymphoblastic leukemia
Sentís, I; Gonzalez, S; Genescà, E; García-Hernández, V; Muiños, F; Gonzalez, C; López-Arribillaga, E; Gonzalez, J; Fernandez-Ibarrondo, L; Mularoni, L; Espinosa, L; Bellosillo, B; Ribera, JM; Bigas, A; Gonzalez-Perez, A; Lopez-Bigas, N
Genome Biology
21
1
284 -
-
2020
ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer
Urosevic, J; Blasco, MT; Llorente, A; Bellmunt, A; Berenguer-Llergo, A; Guiu, M; Cañellas, A; Fernandez, E; Burkov, I; Clapés, M; Cartanà, M; Figueras-Puig, C; Batlle, E; Nebreda, AR; Gomis, RR
Cancer Research
80
21
4668 -
4680
2020
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Mateo, L; Duran-Frigola, M; Gris-Oliver, A; Palafox, M; Scaltriti, M; Razavi, P; Chandarlapaty, S; Arribas, J; Bellet, M; Serra, V; Aloy, P
Genome Medicine
12
1
78 -
-
2020
A compendium of mutational cancer driver genes
Martínez-Jiménez, F; Muiños, F; Sentís, I; Deu-Pons, J; Reyes-Salazar, I; Arnedo-Pac, C; Mularoni, L; Pich, O; Bonet, J; Kranas, H; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Reviews Cancer
20
10
555 -
572
2020
Manipulating the Mediator complex to induce naïve pluripotency
Lynch, CJ; Bernad, R; Calvo, I; Serrano, M
Experimental Cell Research
395
2
112215 -
-
2020
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Mas-Ponte, D; Supek, F
Nature Genetics
52
9
958 -
+
2020
Induction of lysosome membrane permeabilization as a therapeutic strategy to target pancreatic cancer stem cells
Cash, TP; Alcalá, S; Rico-Ferreira, MD; Hernández-Encinas, E; García, J; Albarrán, MI; Valle, S; Muñoz, J; Martínez-González, S; Blanco-Aparicio, C; Pastor, J; Serrano, M; Sainz, B
Cancers
12
7
1790 -
-
2020
Probing the Kinetic and Thermodynamic Fingerprints of Anti-EGF Nanobodies by Surface Plasmon Resonance
Guardiola, S; Varese, M; Taulés, M; Díaz-Lobo, M; García, J; Giralt, E
Pharmaceuticals
13
6
134 -
-
2020
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
Salvadores, M; Fuster-Tormo, F; Supek, F
Science Advances
6
27
eaba1862 -
-
2020
Self-Eating for Muscle Fitness: Autophagy in the Control of Energy Metabolism
Sebastián, D; Zorzano, A
Developmental Cell
54
2
268 -
281
2020
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
Donoghue, C; Cubillos-Rojas, M; Gutierrez-Prat, N; Sanchez-Zarzalejo, C; Verdaguer, X; Riera, A; Nebreda, AR
European Journal Of Medicinal Chemistry
201
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112451 -
-
2020
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer
Dziubanska-Kusibab, PJ; Berger, H; Battistini, F; Bouwman, BAM; Iftekhar, A; Katainen, R; Cajuso, T; Crosetto, N; Orozco, M; Aaltonen, LA; Meyer, TF
Nature Medicine
26
7
1063 -
+
2020
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P
Nature Biotechnology
38
9
1087 -
+
2020
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral, C; Stanisavljevic, J; Hernando-Momblona, X; Mereu, E; Alvarez-Varela, A; Cortina, C; Stork, D; Slebe, F; Turon, G; Whissell, G; Sevillano, M; Merlos-Suárez, A; Casanova-Martí, A; Moutinho, C; Lowe, SW; Dow, LE; Villanueva, A; Sancho, E; Heyn, H; Batlle, E
Cell Stem Cell
26
6
845 -
+
2020
LOBSTER: an environment to design bioimage analysis workflows for large and complex fluorescence microscopy data
Tosi, S; Bardia, L; Filgueira, MJ; Calon, A; Colombelli, J
Bioinformatics
36
8
2634 -
2635
2020
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Pascual, R; Martín, J; Salvador, F; Reina, O; Chanes, V; Millanes-Romero, A; Suñer, C; Fernández-Miranda, G; Bartomeu, A; Huang, YS; Gomis, RR; Méndez, R
Science Advances
6
20
eaax3868 -
-
2020
Hog1 activation delays mitotic exit via phosphorylation of Net1
Tognetti, S; Jiménez, J; Viganò, M; Duch, A; Queralt, E; de Nadal, E; Posas, F
Proceedings Of The National Academy Of Sciences Of The United States Of America
117
16
8924 -
8933
2020
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Sati, S; Bonev, B; Szabo, Q; Jost, D; Bensadoun, P; Serra, F; Loubiere, V; Papadopoulos, GL; Rivera-Mulia, JC; Fritsch, L; Bouret, P; Castillo, D; Gelpi, JLI; Orozco, M; Vaillant, C; Pellestor, F; Bantignies, F; Marti-Renom, MA; Gilbert, DM; Lemaitre, JM; Cavalli, G
Molecular Cell
78
3
522 -
+
2020
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
Sridhar, A; Farr, SE; Portella, G; Schlick, T; Orozco, M; Collepardo-Guevara, R
Proceedings Of The National Academy Of Sciences Of The United States Of America
117
13
7216 -
7224
2020
Synthesis and Application of 3-Bromo-1,2,4,5-Tetrazine for Protein Labeling to Trigger Click-to-Release Biorthogonal Reactions
Ros, E; Bellido, M; Verdaguer, X; de Pouplana, LR; Riera, A
Bioconjugate Chemistry
31
3
933 -
938
2020
P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis
Cabré, A; Riera, A; Verdaguer, X
Accounts Of Chemical Research
53
3
676 -
689
2020
Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols
Cabre, A; Rafael, S; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A
Angewandte Chemie (International Ed. Print)
59
19
7521 -
7527
2020
From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy
Kennel, P; Dichamp, J; Barreau, C; Guissard, C; Teyssedre, L; Rouquette, J; Colombelli, J; Lorsignol, A; Casteilla, L; Plouraboué, F
Plos Computational Biology
16
2
e1007322 -
-
2020
A multi-modal coarse grained model of DNA flexibility mappable to the atomistic level
Walther, J; Dans, PD; Balaceanu, A; Hospital, A; Bayarri, G; Orozco, M
Nucleic Acids Research
48
5
e29 -
-
2020
Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio, L; Milán, M
Developmental Cell
52
5
659 -
+
2020
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