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Research publications

Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio L; Milán M
52
5
659 -
+
2020
The mitochondrial tRNA conundrum
de Pouplana LR
21
7
361 -
361
2020
Gene gain and loss across the metazoan tree of life
Fernández R, Gabaldón T
4
4
524 -
533
2020
The embryonic linker histone dBigH1 alters the functional state of active chromatin
Climent-Cantó P, Carbonell A, Tatarski M, Reina O, Bujosa P, Font-Mateu J, Bernués J, Beato M, Azorín F
48
8
4147 -
4160
2020
Requirement for epithelial p38α in KRAS-driven lung tumor progression
Vitos-Faleato J, Real SM, Gutierrez-Prat N, Villanueva A, Llonch E, Drosten M, Barbacid M, Nebreda AR
117
5
2588 -
2596
2020
Characterization of Human Sperm Protamine Proteoforms through a Combination of Top-Down and Bottom-Up Mass Spectrometry Approaches
Soler-Ventura A; Gay M; Jodar M; Vilanova M; Castillo J; Arauz-Garofalo G; Villarreal L; Ballescà JL; Vilaseca M; Oliva R
19
1
221 -
237
2020
Dendritic cells in cancer immunology and immunotherapy
Wculek SK*, Cueto FJ*, Mujal AM, Melero I, Krummel MF, Sancho D#
(#) Corresponding author; (*) these authors contributed equally
20(1):7-24
2020
Early neutrophil responses to chemical carcinogenesis shape long-term lung cancer susceptibility
Wculek SK*, Bridgeman VL*, Peakman F, Malanchi I#
(#) Corresponding author; (*) these authors contributed equally
23(7):101277
2020
Senolytic CAR T cells reverse senescence-associated pathologies.
Amor C*, Feucht J*, Leibold J*, Ho Y-J, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, et al, Sadelain M, Lowe SW. (*equal contribution).
2020
An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants
Paz Zafra M, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Calvo Fernandez MT, Wilkinson JE, Piskounova E and Dow LE.
2020
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Rosa Pascual, Judit Martín, Fernando Salvador, Oscar Reina, Veronica Chanes, Alba Millanes-Romero, Clara Suñer, Gonzalo Fernández-Miranda, Anna Bartomeu, Yi-Shuian Huang, Roger R Gomis, Raúl Méndez
6
eaax3868
2020
Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E
2020
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Alejo E Rodriguez-Fraticelli, Caleb S Weinreb, Shou Wen Wang, Rosa P Migueles, Maja Jankovic, Marc Usart, Allon M Klein, Sally Lowell, Fernando D Camargo
2020
Lineage tracing on transcriptional landscapes links state to fate during differentiation
Caleb S Weinreb(#), Alejo E Rodriguez-Fraticelli(#), Fernando D Camargo, Allon M Klein (# Equal contribution)
2020
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Isabel Hernandez-Alvarez, Maria; Sebastian, David; Vives, Sara; Ivanova, Saska; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sonia R.; Hernandez, Vanessa; Vasconcelos, Nuno; Peddinti, Gopal; Adrover, Anna; Jove, Mariona; Pamplona, Reinald; Gordaliza-Alaguero, Isabel; Calvo, Enrique; Cabre, Noemi; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Rodrigues, Cecilia M. P.; Orozco, Modesto; Joven, Jorge; Canto, Carles; Palacin, Manuel; Fernandez-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio;
177
4
881 -
+
2019
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh B; Banduseela V; Chiesa G; Martínez-Cristóbal P; Rauch J; Nath S; Schwarz D; Shao H; Marin-Argany M; Di Sanza C; Giorgetti E; Yu Z; Pieratelli R; Felli I; Brun-Heath I; García J; Nebreda Á; Gestwicki J; Lieberman A; Salvatella X
10
3562
3562 -
2019
The Expansion of Inosine at the Wobble Position of tRNAs, and Its Role in the Evolution of Proteomes
Rafels-Ybern, Albert; Gabriel Torres, Adrian; Camacho, Noelia; Herencia-Ropero, Andrea; Roura Frigole, Helena; Wulff, Thomas F; Raboteg, Marina; Bordons, Albert; Grau-Bove, Xavier; Ruiz-Trillo, Inaki; Ribas de Pouplana, Lluis
36
4
650 -
662
2019
Evolutionary and functional patterns of shared gene neighbourhood in fungi
Marcet-Houben M; Gabaldón T
4
12
2383 -
2392
2019
The mutational footprints of cancer therapies
Pich O; Muiños F; Lolkema M; Steeghs N; Gonzalez-Perez A; Lopez-Bigas N
51
12
1732 -
+
2019
OncodriveCLUSTL: A sequence-based clustering method to identify cancer drivers
Arnedo-Pac C; Mularoni L; Muiños F; Gonzalez-Perez A; Lopez-Bigas N; Schwartz R
35
22
4788 -
4790
2019
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Lindeboom RGH; Vermeulen M; Lehner B; Supek F
51
11
1645 -
+
2019
Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
Aragón E; Wang Q; Zou Y; Morgani SM; Ruiz L; Kaczmarska Z; Su J; Torner C; Tian L; Hu J; Shu W; Agrawal S; Gomes T; Márquez JA; Hadjantonakis AK; Macias MJ; Massagué J
33
21-22
1506 -
1524
2019
Inducible slc7a7 knockout mouse model recapitulates lysinuric protein intolerance disease
Bodoy S; Sotillo F; Espino-Guarch M; Sperandeo MP; Ormazabal A; Zorzano A; Sebastio G; Artuch R; Palacín M
20
21
5294 -
2019
Cellular Senescence: Defining a Path Forward
Gorgoulis V; Adams PD; Alimonti A; Bennett DC; Bischof O; Bishop C; Campisi J; Collado M; Evangelou K; Ferbeyre G; Gil J; Hara E; Krizhanovsky V; Jurk D; Maier AB; Narita M; Niedernhofer L; Passos JF; Robbins PD; Schmitt CA; Sedivy J; Vougas K; von Zglinicki T; Zhou D; Serrano M; Demaria M
179
4
813 -
827
2019
Top-down proteomics applied to human cerebrospinal fluid
Gay M; Sánchez-Jiménez E; Villarreal L; Vilanova M; Huguet R; Arauz-Garofalo G; Díaz-Lobo M; López-Ferrer D; Vilaseca M
2044
193 -
219
2019
A five-level classification system for proteoform identifications
Smith LM; Thomas PM; Shortreed MR; Schaffer LV; Fellers RT; LeDuc RD; Tucholski T; Ge Y; Agar JN; Anderson LC; Chamot-Rooke J; Gault J; Loo JA; Paša-Toli? L; Robinson CV; Schlüter H; Tsybin YO; Vilaseca M; Vizcaíno JA; Danis PO; Kelleher NL
16
10
939 -
940
2019
Atomic structure of the Epstein-Barr virus portal
Machón C; Fàbrega-Ferrer M; Zhou D; Cuervo A; Carrascosa J; Stuart D; Coll M
10
3891
3891 -
2019
Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
Cuervo A; Fàbrega-Ferrer M; Machón C; Conesa J; Fernández F; Pérez-Luque R; Pérez-Ruiz M; Pous J; Vega M; Carrascosa J; Coll M
10
3746
3746 -
2019
The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila
Molnar C; Heinen JP; Reina J; Llamazares S; Palumbo E; Breschi A; Gay M; Villarreal L; Vilaseca M; Pollarolo G; Gonzalez C
5
8
eaaw7965 -
2019
Sidekick Is a Key Component of Tricellular Adherens Junctions that Acts to Resolve Cell Rearrangements
Letizia A; He DQ; Astigarraga S; Colombelli J; Hatini V; Llimargas M; Treisman JE
50
3
313 -
+
2019
Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
Batlle R; Andrés E; Gonzalez L; Llonch E; Igea A; Gutierrez-Prat N; Berenguer-Llergo A; Nebreda A
10
3071
3071 -
2019
The chemistry of senescence
Lozano-Torres B; Estepa-Fernández A; Rovira M; Orzáez M; Serrano M; Martínez-Máñez R; Sancenón F
3
7
426 -
441
2019
Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage
Murcia L; Clemente-Ruiz M; Pierre-Elies P; Royou A; Milán M
28
1
119 -
+
2019
An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases
Aranda J; Terrazas M; Gómez H; Villegas N; Orozco M
2
6
544 -
552
2019
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study
Iacobucci C; Piotrowski C; Aebersold R; Amaral BC; Andrews P; Bernfur K; Borchers C; Brodie NI; Bruce JE; Cao Y; Chaignepain S; Chavez JD; Claverol S; Cox J; Davis T; Degliesposti G; Dong MQ; Edinger N; Emanuelsson C; Gay M; Götze M; Gomes-Neto F; Gozzo FC; Gutierrez C; Haupt C; Heck AJR; Herzog F; Huang L; Hoopmann MR; Kalisman N; Klykov O; Kuka?ka Z; Liu F; Maccoss MJ; Mechtler K; Mesika R; Moritz RL; Nagaraj N; Nesati V; Neves-Ferreira AGC; Iacobucci C; Piotrowski C; Aebersold R; Amaral BC; Andrews P; Bernfur K; Borchers C; Brodie NI; Bruce JE; Cao Y; Chaignepain S; Chavez JD; Claverol S; Cox J; Davis T; Degliesposti G; Dong MQ; Edinger N; Emanuelsson C; Gay M; Götze M; Gomes-Neto F; Gozzo FC; Gutierrez C; Haupt C; Heck AJR; Herzog F; Huang L; Hoopmann MR; Kalisman N; Klykov O; Kuka?ka Z; Liu F; Maccoss MJ
91
11
6953 -
6961
2019
Defining the Independence of the Liver Circadian Clock
Koronowski KB; Kinouchi K; Welz PS; Smith JG; Zinna VM; Shi J; Samad M; Chen S; Magnan CN; Kinchen JM; Li W; Baldi P; Benitah SA; Sassone-Corsi P
177
6
1448 -
+
2019
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
Welz PS; Zinna VM; Symeonidi A; Koronowski KB; Kinouchi K; Smith JG; Guillén IM; Castellanos A; Crainiciuc G; Prats N; Caballero JM; Hidalgo A; Sassone-Corsi P; Benitah SA
177
6
1436 -
+
2019
Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments
Torres AG; Reina O; Attolini CSO; De Pouplana LR
116
17
8451 -
8456
2019
Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain
Detrez JR; Maurin H; Van Kolen K; Willems R; Colombelli J; Lechat B; Roucourt B; Van Leuven F; Baatout S; Larsen P; Nuydens R; Timmermans JP; De Vos WH
127
398 -
409
2019
Lysosomal trapping of palbociclib and its functional implications
Llanos S; Megias D; Blanco-Aparicio C; Hernández-Encinas E; Rovira M; Pietrocola F; Serrano M
38
20
3886 -
3902
2019
Highly Enantioselective Iridium-Catalyzed Hydrogenation of 2-Aryl Allyl Phthalimides
Cabre, Albert; Romagnoli, Elia; Martinez-Balart, Pol; Verdaguer, Xavier; Riera, Antoni
21
23
9709 -
9713
2019
CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression
Cano-Crespo S, Chillarón J, Junza A, Fernández-Miranda G, García J, Polte C, R de la Ballina L, Ignatova Z, Yanes Ó, Zorzano A, Stephan-Otto Attolini C, Palacín M
9
14065
14065 -
14065
2019
Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
Pittolo S; Lee H; Lladó A; Tosi S; Bosch M; Bardia L; Gómez-Santacana X; Llebaria A; Soriano E; Colombelli J; Poskanzer K; Perea G; Gorostiza P
116
27
13680 -
13689
2019
The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry
Terrazas M; Genna V; Portella G; Villegas N; Sánchez D; Arnan C; Pulido-Quetglas C; Johnson R; Guigó R; Brun-Heath I; Aviñó A; Eritja R; Orozco M
5
6
1619 -
1631
2019
Autophagy-induced senescence is regulated by p38α signaling
Slobodnyuk K; Radic N; Ivanova S; Llado A; Trempolec N; Zorzano A; Nebreda A
10
376
376 -
2019
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Orellana L; Thorne AH; Lema R; Gustavsson J; Parisian AD; Hospital A; Cordeiro TN; Bernadó P; Scott AM; Brun-Heath I; Lindahl E; Cavenee WK; Furnari FB; Orozco M
116
20
10009 -
10018
2019
Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
Terré B; Lewis M; Gil-Gómez G; Han Z; Lu H; Aguilera M; Prats N; Roy S; Zhao H; Stracker TH
146
8
dev162628 -
2019
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo A; Topal B; Kunze M; Aranda J; Chiesa G; Mungianu D; Bernardo-Seisdedos G; Eftekharzadeh B; Gairí M; Pierattelli R; Felli I; Diercks T; Millet O; García J; Orozco M; Crehuet R; Lindorff-Larsen K; Salvatella X
10
2034
2034 -
2019