OncologySignalling and Cell Cycle Laboratory

Signalling and Cell Cycle Laboratory
<p>Angel R Nebreda</p>
Group Leader

ICREA Research Professor, ERC Advanced Grant

+34 93 40 31379

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:

  1. Mechanisms of signal integration by p38 MAP kinases and their role in cancer
  2. Regulation and role of the RINGO/Speedy proteins, a new family of CDK activators.
Trempolec N, Muñoz JP, Slobodnyuk K, Marin S, Cascante M, Zorzano A and Nebreda AR.
Sci Rep, 7 (1), 11367 (2017)
Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y and Nebreda AR.
Nat Commun, 7 11084 (2016)
Clemente-Ruiz M, Murillo-Maldonado JM, Benhra N, Barrio L, Pérez L, Quiroga G, Nebreda AR and Milán M.
Dev Cell, 36 (3), 290-302 (2016)
Igea A and Nebreda AR.
Cancer Res, 75 (19), 3997-4002 (2015)
Gupta J, del Barco Barrantes I, Igea A, Sakellariou S, Pateras IS, Gorgoulis VG and Nebreda AR.
Cancer Cell, 25 (4), 484-500 (2014)
Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR and Gomis RR.
Nat Cell Biol, 16 (7), 685-94 (2014)
Pereira L, Igea A, Canovas B, Dolado I and Nebreda AR.
EMBO Mol Med, 5 (11), 1759-1774 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (3), 656-657 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (4), 924-925 (2013)
del Barco Barrantes I, Coya JM, Maina F, Arthur JS and Nebreda AR.
P Natl Acad Sci Usa, 108 (31), 12764-9 (2011)
Cuadrado A and Nebreda AR.
Biochem J, 429 (3), 403-17 (2010)

The Signalling and cell cycle laboratory receives financial support from the following sources:

  • European Research Council
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Intestine of a patient  with ulcerative colitis, a chronic inflammatory disease of the intestine. Macrophage marker is shown in green, activated p38 protein in red, and nucleus in blue. Author: Catrin Youssif, IRB Barcelona</p>
11 Jul 2018

Científicos del Instituto de Investigación Biomédica (IRB Barcelona) liderados por el investigador ICREA Angel R.

5 Jun 2018

Este fin de semana, 9 y 10 de junio, el Parc de la Ciutadella será el escenario de la 12ª edición del

<p>Group Leader Angel R. Nebreda and PhD student Begoña Cánovas at the Signalling and Cell Cycle Laboratory (M. Minocri, IRB Barcelona)</p>
30 May 2018

La Voz de Galicia, TV3 y 8TV, entre otros medios de comunicación, han entrevistado a Begoña Cánovas, primera autora del reciente estudio del IRB Barcelona, publicado en la revista Cancer Cell, que

<p>Image of breast cancer cells derived from a mouse mammary tumour (in blue: nucleus, in green: tubulin) Author: Begoña Cánovas, IRB Barcelona</p>
30 May 2018

El País, Ara, La Razón, El Economista, News-Medical, Medical Xpress, entre otros medios de comunicación nacionales e internacionales, han publicado un artículo sobre la reciente investigación lider

Upcoming events

27 Jul
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Evripidis Gavathiotis, PhD – Associate Professor – Department of Biochemistry – Department of Medicine – Center for Experimental Therapeutics Albert Einstein Cancer Research – Wilf Family Cardiovascular Research Institute – Institute of Aging Research – N