Oncology Signalling and Cell Cycle Laboratory

Signalling and Cell Cycle Laboratory
<p>Angel R Nebreda</p>
Group Leader

ICREA Research Professor, ERC Advanced Grant

+34 93 40 31379

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:

  1. Mechanisms of signal integration by p38 MAP kinases and their role in cancer
  2. Regulation and role of the RINGO/Speedy proteins, a new family of CDK activators.
Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH and Nebreda AR.
Cancer Cell, 33 (6), 1094-1110. (2018)
Trempolec N, Muñoz JP, Slobodnyuk K, Marin S, Cascante M, Zorzano A and Nebreda AR.
Sci Rep, 7 (1), 11367 (2017)
Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y and Nebreda AR.
Nat Commun, 7 11084 (2016)
Clemente-Ruiz M, Murillo-Maldonado JM, Benhra N, Barrio L, Pérez L, Quiroga G, Nebreda AR and Milán M.
Dev Cell, 36 (3), 290-302 (2016)
Igea A and Nebreda AR.
Cancer Res, 75 (19), 3997-4002 (2015)
Gupta J, del Barco Barrantes I, Igea A, Sakellariou S, Pateras IS, Gorgoulis VG and Nebreda AR.
Cancer Cell, 25 (4), 484-500 (2014)
Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR and Gomis RR.
Nat Cell Biol, 16 (7), 685-94 (2014)
Pereira L, Igea A, Canovas B, Dolado I and Nebreda AR.
EMBO Mol Med, 5 (11), 1759-1774 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (3), 656-657 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (4), 924-925 (2013)
del Barco Barrantes I, Coya JM, Maina F, Arthur JS and Nebreda AR.
P Natl Acad Sci Usa, 108 (31), 12764-9 (2011)
Cuadrado A and Nebreda AR.
Biochem J, 429 (3), 403-17 (2010)

The Signalling and cell cycle laboratory receives financial support from the following sources:

  • European Research Council
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"