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Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes


Organizer: IRB BioMed Seminars

Date: Wed 17th April at 15:00

Place: Fèlix Serratosa

Speaker: Sa Kan Yoo MD, Ph.D. Team Leader Laboratory for Homeodynamics - RIKEN Center for Biosystems Dynamics Research (BDR)
Kobe Campus, Japan.   https://scholar.google.com/citations?user=tmOceU0AAAAJ&hl=en

Title: "Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes"

Host: Marco Milán, PhD - Programme Chair - Group Leader - Development and Growth Control LAB - IRB Barcelona - Mechanisms of Disease Programme.



Many adult tissues are composed of differentiated cells and stem cells, each working in a coordinated manner to maintain tissue homeostasis during physiological cell turnover. Old differentiated cells are believed to typically die by apoptosis. Recently we discovered a previously uncharacterized, new phenomenon, which we named erebosis based on the ancient Greek word erebos (“complete darkness”), in the gut enterocytes of adult Drosophila. Cells that undergo erebosis lose cytoskeleton, cell adhesion, organelles and fluorescent proteins, but accumulate Angiotensin-converting enzyme (Ance). Their nuclei become flat and occasionally difficult to detect. Erebotic cells do not have characteristic features of apoptosis, necrosis, or autophagic cell death. Inhibition of apoptosis prevents neither the gut cell turnover nor erebosis. Erebosis is considered a cell death mechanism for the enterocyte flux to mediate tissue homeostasis in the gut. I will discuss our latest progress towards understanding of the erebosis mechanism.

IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar