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Structure and dynamics of Smad complexes

Seminaris IRB Barcelona BioMed
17 set. 21

Speaker: Maria J. Macias, PhD. – Group Leader - Structural Characterization of Macromolecular Assemblies Lab - Mechanisms of Disease Programme - IRB Barcelona

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Presentation

Organizer: IRB Barcelona

Date: Friday 17 September 2021, 12PM

Title: "Structure and dynamics of Smad complexes"

Host: Manuel Palacín, PhD -  Amino Acid Transporters and Disease Lab - Aging & Metabolism Programme - IRB Barcelona

Abstract:

Our lab aims to describe how biological processes occur and their role in human diseases using high-resolution structural biology. A large part of our work is devoted to clarify the role of SMAD transcription factors in TGF-β signaling. I will present our results related to complex structures of Smad proteins and two cofactors, and the conformational landscape that two Smads FL proteins adopt in solution. I will also take the opportunity to comment on the AlphaFold2 and RoseTTAfold programs.

 

Biomed Webinar

Open to predoctoral UPF students

If you are interested in participating please send an email to cristina.mendez@irbbarcelona.org