Speaker: Maria J. Macias, PhD. – Group Leader - Structural Characterization of Macromolecular Assemblies Lab - Mechanisms of Disease Programme - IRB Barcelona
Organizer: IRB Barcelona
Date: Friday 17 September 2021, 12PM
Title: "Structure and dynamics of Smad complexes"
Host: Manuel Palacín, PhD - Amino Acid Transporters and Disease Lab - Aging & Metabolism Programme - IRB Barcelona
Our lab aims to describe how biological processes occur and their role in human diseases using high-resolution structural biology. A large part of our work is devoted to clarify the role of SMAD transcription factors in TGF-β signaling. I will present our results related to complex structures of Smad proteins and two cofactors, and the conformational landscape that two Smads FL proteins adopt in solution. I will also take the opportunity to comment on the AlphaFold2 and RoseTTAfold programs.
Open to predoctoral UPF students
If you are interested in participating please send an email to firstname.lastname@example.org