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Targeting the origins of genomic instability associated cell fitness in cancer


Organizer: IRB BioMed Seminars

Date: Friday 30 June 2023, 12:00h
Place: Felix Serratosa Hall, PCB

Speaker: Samuel Aparicio, PhD. Professor, Distinguished Scientist, Department Head, Department of Molecular Oncology - BC Cancer Research Institute - The University of British Columbia, UBC. Vancouver, Canada

Title: "Targeting the origins of genomic instability associated cell fitness in cancer"

Host: Dr. Núria López Bigas, Group Leader - Biomedical Genomics Laboratory- IRB Barcelona - Cancer Science Programme.



Over the last decade we have decoded the influence of mutation at different scales in cancer evolution, tissue cellular population dynamics and the role in drug resistance using combined genomics and computational methods. Recently using novel single cell genome sequencing methods (Laks et al, Cell 2019) we have identified the causes and consequences of copy number structural mutations in solid cancers (Funnell et al Nature 2022), identifying genotypic resistance to DNA targeting agents (Salehi et al, Nature 2021). I will describe a novel approach to targeting cancer: we have identified small molecules that bind G-quadruplex secondary structure in the genome, with clinical activity in DNA repair deficient cancers.


IRB BioMed Seminar


IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.


In collaboration with:

fundación bbva