Tuning the Cell’s Antenna: Protein Targeting to Primary Cilia [IRB Research Nodes Seminar]

Host: Dr. Jens Lüders, Group Leader - Microtubule organization in cell proliferation and differentiation - IRB Barcelona 

Node: Cell Pathophysiology / Preclinical Models of Disease

Date: Wednesday 7 June 2023, 12.00h

Place: Serratosa Room

IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.

Abstract

Primary cilia are microtubule protrusions of the plasma membrane that function as cell type-specific antennae in many of our tissues. These antennae must be tuned in order to perform their key signaling functions. Such tuning involves the correct ciliary targeting of proteins implicated in ciliary signaling. In this talk, we will focus on the ciliary targeting of INPP5E, a phosphoinositide phosphatase that controls ciliary composition and function, and whose mutations cause diseases known as ciliopathies.