IRB Barcelona logo

Research

At the forefront of biomedicine

Research publications

DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
Barissi, S; Sala, A; Wieczór, M; Battistini, F; Orozco, M
Nucleic Acids Research
50
16
9105 -
9114
2022
Discovering the drivers of clonal hematopoiesis
Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Communications
13
1
4267 -
2022
A single WNT enhancer drives specification and regeneration of the Drosophila wing
Gracia-Latorre, E; Pérez, L; Muzzopappa, M; Milán, M
Nature Communications
13
1
4794 -
2022
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
Alvarez, MM; Biayna, J; Supek, F
Nature Communications
13
1
4520 -
2022
PerSVade: personalized structural variant detection in any species of interest
Schikora-Tamarit, MA; Gabaldón, T
Genome Biology
23
1
175 -
2022
The impact of rare germline variants on human somatic mutation processes
Vali-Pour, M; Lehner, B; Supek, F
Nature Communications
13
1
3724 -
2022
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Delaunay, S; Pascual, G; Feng, BH; Klann, K; Behm, M; Hotz-Wagenblatt, A; Richter, K; Zaoui, K; Herpel, E; Munch, C; Dietmann, S; Hess, J; Benitah, SA; Frye, M
Nature
607
7919
593 -
+
2022
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Delaunay, S; Pascual, G; Feng, BH; Klann, K; Behm, M; Hotz-Wagenblatt, A; Richter, K; Zaoui, K; Herpel, E; Munch, C; Dietmann, S; Hess, J; Benitah, SA; Frye, M
Nature
607
7919
593 -
+
2022
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E
Nature Cancer
3
9
1052 -
+
2022
BioExcel Building Blocks Workflows (BioBB-Wfs), an integrated web-based platform for biomolecular simulations
Bayarri, G; Andrio, P; Orozco, M; Gelpí, JL
Nucleic Acids Research
50
W1
W99 -
W107
2022
Chasing molecular glue degraders: screening approaches
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C
Chemical Society Reviews
51
13
5498 -
5517
2022
Chasing molecular glue degraders: screening approaches
Domostegui, A; Nieto-Barrado, L; Perez-Lopez, C; Mayor-Ruiz, C
Chemical Society Reviews
51
13
5498 -
5517
2022
Conformational ensemble of the TNF-derived peptide solnatide in solution
Martin-Malpartida, P; Arrastia-Casado, S; Farrera-Sinfreu, J; Lucas, R; Fischer, H; Fischer, B; Eaton, DC; Tzotzos, S; Macias, MJ
Computational And Structural Biotechnology Journal
20
2082 -
2090
2022
Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors
Willis, JR; Saus, E; Iraola-Guzman, S; Ksiezopolska, E; Cozzuto, L; Bejarano, LA; Andreu-Somavilla, N; Alloza-Trabado, M; Blanco, A; Puig-Sola, A; Broglio, E; Carolis, C; Ponomarenko, J; Hecht, J; Gabaldón, T
Npj Biofilms And Microbiomes
8
1
38 -
2022
Natural killer cells act as an extrinsic barrier for in vivo reprogramming
Melendez, E; Chondronasiou, D; Mosteiro, L; de Villarreal, JM; Fernandez-Alfara, M; Lynch, CJ; Grimm, D; Real, FX; Alcami, J; Climent, N; Pietrocola, F; Serrano, M
Development
149
8
dev200361 -
2022
Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback
Tartour, K; Andriani, F; Folco, EG; Letkova, D; Schneider, R; Saidi, I; Sato, T; Welz, PS; Benitah, SA; Allier, C; Padmanabhan, K
Nature Structural & Molecular Biology
29
6
549 -
+
2022
Mutational signatures are markers of drug sensitivity of cancer cells
Levati, J; Salvadores, M; Fuster-Tormo, F; Supek, F
Nature Communications
13
1
2926 -
2022
Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation
Suñer, C; Sibilio, A; Martín, J; Castellazzi, CL; Reina, O; Dotu, I; Caballé, A; Rivas, E; Calderone, V; Díez, J; Nebreda, AR; Méndez, R
Elife
11
e75873 -
2022
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R;...
Nature Cancer
3
4
418 -
+
2022
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Chondronasiou, D; Gill, D; Mosteiro, L; Urdinguio, RG; Berenguer, A; Aguilera, M; Durand, S; Aprahamian, F; Nirmalathasan, N; Abad, M; Martin-Herranz, DE; Otto-Attolini, CS; Prats, N; Kroemer, G; Fraga, MF; Reik, W; Serrano, M
Aging Cell
21
3
e13578 -
2022
Proteomic tools for the quantitative analysis of artificial peptide libraries: detection and characterization of target-amplified PD-1 inhibitors
Gay, M; Díaz-Lobo, M; Gusi-Vives, M; Arauz-Garofalo, G; Vilanova, M; Giralt, E; Vilaseca, M; Guardiola, S
Chembiochem
23
12
e202200152 -
2022
Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission
Calvet, J; Berenguer-Llergo, A; Gay, M; Massanella, M; Domingo, P; Llop, M; Sánchez-Jiménez, E; Arévalo, M; Carrillo, J; Albiñana, N; Arauz-Garofalo, G; Orellana, C; Delgado, JF; Serrano, A; Llobell, A; Graell, E; García-Manrique, M; Moreno, M; Galisteo, C; Casado, E; Navarro, N; Gómez, A; Garcia-Cirera, S; Rusiñol, M; Costa, E; Clotet, B;...
Scientific Reports
12
1
640 -
2022
HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings: HTSDSF Explorer, a tool for DSF screenings
Martin-Malpartida, P; Hausvik, E; Underhaug, J; Torner, C; Martinez, A; Macias, MJ
Journal Of Molecular Biology
434
11
167372 -
2022
Overcoming TGF beta-mediated immune evasion in cancer
Tauriello, DVF; Sancho, E; Batlle, E
Nature Reviews Cancer
22
1
25 -
44
2022
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation
Cabré, A; Verdaguer, X; Riera, A
Chemical Reviews
122
1
269 -
339
2022
Heteroplasmy of wild type mitochondrial DNA variants in mice causes metabolic heart disease with pulmonary hypertension and frailty
Lechuga-Vieco AV
Circulation
2022
Metabolism of tissue macrophages in homeostasis and pathology
Wculek SK#, Dunphy G, Heras-Murillo I, Mastrangelo A, Sancho D#
(#) Corresponding author
Cellular and Molecular Immunology
19(3):384-408
2022
AutoScanJ: A Suite of ImageJ Scripts for Intelligent Microscopy
Tosi, S; Lladó, A; Bardia, L; Rebollo, E; Godo, A; Stockinger, P; Colombelli, J
Frontiers In Bioinformatics
1
627626 -
2021
The long non-coding RNA landscape of Candida yeast pathogens
Hovhannisyan, H; Gabaldon, T
Nature Communications
12
1
7317 -
2021
Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata
Ksiezopolska, E; Schikora-Tamarit, MA; Beyer, R; Nunez-Rodriguez, JC; Schuller, C; Gabaldon, T
Current Biology
31
23
5314 -
+
2021
Structural basis for substrate specificity of heteromeric transporters of neutral amino acids
Rodriguez, CF; Escudero-Bravo, P; Diaz, L; Bartoccioni, P; Garcia-Martin, C; Gilabert, JG; Boskovic, J; Guallar, V; Errasti-Murugarren, E; Llorca, O; Palacin, M
Proceedings Of The National Academy Of Sciences Of The United States Of America
118
49
e2113573118 -
2021
Dietary palmitic acid promotes a prometastatic memory via Schwann cells
Pascual, G; Dominguez, D; Elosua-Bayes, M; Beckedorff, F; Laudanna, C; Bigas, C; Douillet, D; Greco, C; Symeonidi, A; Hernandez, I; Gil, SR; Prats, N; Bescos, C; Shiekhattar, R; Amit, M; Heyn, H; Shilatifard, A; Benitah, SA
Nature
599
7885
485 -
+
2021
Control of hormone-driven organ disassembly by ECM remodeling and Yorkie-dependent apoptosis
Fraire-Zamora, JJ; Tosi, S; Solon, J; Casanova, J
Current Biology
31
23
5261 -
+
2021
Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in App(NL-G-F), App(NL-F), and 3xTg-AD mouse models
Pauls, E; Bayod, S; Mateo, L; Alcalde, V; Juan-Blanco, T; Sanchez-Soto, M; Saido, TC; Saito, T; Berrenguer-Llergo, A; Attolini, CSO; Gay, M; de Oliveira, E; Duran-Frigola, M; Aloy, P
Genome Medicine
13
1
168 -
2021
Sub-centrosomal mapping identifies augmin-gamma TuRC as part of a centriole-stabilizing scaffold
Schweizer, N; Haren, L; Dutto, I; Viais, R; Lacasa, C; Merdes, A; Luders, J
Nature Communications
12
1
6042 -
2021
Conformational landscape of multidomain SMAD proteins
Gomes, T; Martin-Malpartida, P; Ruiz, L; Aragón, E; Cordeiro, TN; Macias, MJ
Computational And Structural Biotechnology Journal
19
5210 -
5224
2021
MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate
Gutierrez-Prat, N; Cubillos-Rojas, M; Canovas, B; Kuzmanic, A; Gupta, J; Igea, A; Llonch, E; Gaestel, M; Nebreda, AR
Proceedings Of The National Academy Of Sciences Of The United States Of America
118
29
e2024562118 -
2021
Probing allosteric regulations with coevolution-driven molecular simulations
Colizzi, F; Orozco, M
Science Advances
7
37
eabj0786 -
2021
Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development
Viais, R; Fariña-Mosquera, M; Villamor-Payà, M; Watanabe, S; Palenzuela, L; Lacasa, C; Lüders, J
Elife
10
e67989 -
2021
In silico saturation mutagenesis of cancer genes
Muiños, F; Martínez-Jiménez, F; Pich, O; Gonzalez-Perez, A; Lopez-Bigas, N
Nature
596
7872
428 -
+
2021
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M
Developmental Cell
56
14
2043 -
+
2021
Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development
Avgustinova, A; Laudanna, C; Pascual-García, M; Rovira, Q; Djurec, M; Castellanos, A; Urdiroz-Urricelqui, U; Marchese, D; Prats, N; Van Keymeulen, A; Heyn, H; Vaquerizas, JM; Benitah, SA
Cell Stem Cell
28
10
1790 -
+
2021
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
Scholes, NS; Mayor-Ruiz, C; Winter, GE
Cell Chemical Biology
28
7
1048 -
1060
2021
Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins
Torres, AG; Rodríguez-Escribà, M; Marcet-Houben, M; Vieira, HGS; Camacho, N; Catena, H; Recio, MM; Rafels-Ybern, A; Reina, O; Torres, FM; Pardo-Saganta, A; Gabaldón, T; Novoa, EM; de Pouplana, LR
Nucleic Acids Research
49
12
7011 -
7034
2021
Bioactivity descriptors for uncharacterized chemical compounds
Bertoni, M; Duran-Frigola, M; Badia-i-Mompel, P; Pauls, E; Orozco-Ruiz, M; Guitart-Pla, O; Alcalde, V; Diaz, VM; Berenguer-Llergo, A; Brun-Heath, I; Villegas, N; de Herreros, AG; Aloy, P
Nature Communications
12
1
3932 -
2021
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
Serra, SA; Stojakovic, P; Amat, R; Rubio-Moscardo, F; Latorre, P; Seisenbacher, G; Canadell, D; Böttcher, R; Aregger, M; Moffat, J; de Nadal, E; Valverde, MA; Posas, F
Proceedings Of The National Academy Of Sciences Of The United States Of America
118
23
e2025013118 -
2021
Impact of DNA methylation on 3D genome structure
Buitrago, D; Labrador, M; Arcon, JP; Lema, R; Flores, O; Esteve-Codina, A; Blanc, J; Villegas, N; Bellido, D; Gut, M; Dans, PD; Heath, SC; Gut, IG; Heath, IB; Orozco, M
Nature Communications
12
1
3243 -
2021
Protamine characterization by top-down proteomics: Boosting proteoform identification with dbscan
Arauz-Garofalo, G; Jodar, M; Vilanova, M; Rodriguez, AD; Castillo, J; Soler-Ventura, A; Oliva, R; Vilaseca, M; Gay, M
Proteomes
9
2
21 -
2021