Eduard Batlle

    <p>Batlle</p>
    Research Group: 
    Colorectal Cancer Laboratory
    Unit: 
    CANCER SCIENCE
    Position: 
    Group Leader
    Office: 
    EM01B51-52
    Telephone: 
    +34 93 40 39008
    Email: 
    eduard.batlle@irbbarcelona.org

    ICREA Research Professor, ERC Advanced Grant

     

    View research group

    Since 2004, working as a Research Professor at ICREA (Catalan Institute for Research and Advanced Studies) and Principal Investigator and Programme Coordinator at the Oncology Programme at the Institute for Research in Biomedicine (IRB Barcelona).

    1994-1999 PhD fellow at Institut Municipal de Investigació Mèdica (IMIM). 1993 BSc. Universitat de Barcelona. 1999: Associate professor in Biochemistry –Life Siciences at the University Pompeu Fabra, Barcelona. 1999- 2000 PostDoctoral Fellow at Miguel Beato’s group- Institut für Molekularbiologie und Tumorforschung, Marburg. Germany. 2000-2004: PostDoctoral Fellow at Hans Clevers Lab, Netherlands Institute for Developmental Biology, Utrecht, NL.

    Research activity in the last ten years has focused on the characterization of the mechanisms that drive colorectal cancer initiation and progression. Among other findings, Eduard Batlle originally discovered the transcription factor Snail as a suppressor of E-cadherin expression in tumor cells and more recently the role of EphB receptors in colorectal cancer. His articles published in the last six years have been quoted more than 800 times and have received several reviews and comments in prestigious journals.

    Meet our scientists Videos

    Eduard Batlle: "Deconstruir el càncer de còlon"

    Selected group publications

    Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
    Morral C, Stanisavljevic J, Hernando-Momblona X, Mereu E, Álvarez-Varela A, Cortina C, Stork D, Slebe F, Turon G, Whissell G, Sevillano M, Merlos-Suárez A, Casanova-Martí À, Moutinho C, Lowe SW, Dow LE, Villanueva A, Sancho E, Heyn H and Batlle E.
    Cell Stem Cell, 26 (6), 845-861.e1 (2020)
    Transforming Growth Factor-β Signaling in Immunity and Cancer
    Batlle E and Massagué J.
    Immunity, 50 (4), 924-940 (2019)
    TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
    Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS and Batlle E.
    Nature, 554 (7693), 538-543 (2018)
    Cancer stem cells revisited
    Batlle E and Clevers H.
    Nat Med, 23 (10), 1124-1134 (2017)
    A genome editing approach to study cancer stem cells in human tumors
    Cortina C, Turon G, Stork D, Hernando-Momblona X, Sevillano M, Aguilera M, Tosi S, Merlos-Suárez A, Stephan-Otto Attolini C, Sancho E and Batlle E.
    EMBO Mol Med, 9 (7), 869-879 (2017)
    Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
    Barriga FM, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X, Sevillano M, Guillaumet-Adkins A, Rodriguez-Esteban G, Buczacki SJA, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS, Gut I and Batlle E.
    Cell Stem Cell, 20 (6), 801-816.e7 (2017)
    Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
    Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, Sevillano M, Palomo-Ponce S, Tauriello DV, Byrom D, Cortina C, Morral C, Barceló C, Tosi S, Riera A, Attolini CS, Rossell D, Sancho E and Batlle E.
    Nat Genet, 47 (4), 320-329 (2015)
    Metastatic stem cells: sources, niches, and vital pathways
    Oskarsson T, Batlle E and Massagué J.
    Cell Stem Cell, 14 (3), 306-21 (2014)
    The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression
    Whissell G, Montagni E, Martinelli P, Hernando-Momblona X, Sevillano M, Jung P, Cortina C, Calon A, Abuli A, Castells A, Castellvi-Bel S, Nacht AS, Sancho E, Stephan-Otto Attolini C, Vicent GP, Real FX and Batlle E.
    Nat Cell Biol, 16 (7), 695-707 (2014)
    Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH
    Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR and Gomis RR.
    Nat Cell Biol, 16 (7), 685-94 (2014)
    Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation
    Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massagué J, Sancho E and Batlle E.
    Cancer Cell, 22 (5), 571-84 (2012)
    Specific GATA factors act as conserved inducers of an endodermal-EMT
    Campbell K, Whissell G, Franch-Marro X, Batlle E and Casanova J.
    Dev Cell, 21 (6), 1051-61 (2011)
    Isolation and in vitro expansion of human colonic stem cells
    Jung P, Sato T, Merlos-Suárez A, Barriga FM, Iglesias M, Rossell D, Auer H, Gallardo M, Blasco MA, Sancho E, Clevers H and Batlle E.
    Nat Med, 17 (10), 1225-7 (2011)
    Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
    Solanas G, Cortina C, Sevillano M and Batlle E.
    Nat Cell Biol, 13 (9), 1100-7 (2011)
    The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
    Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Muñoz P, Clevers H, Sancho E, Mangues R and Batlle E.
    Cell Stem Cell, 8 (5), 511-24 (2011)
    Full publication list