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Research

At the forefront of biomedicine

Dr. Eduard Batlle

Dr. Eduard Batlle
Unit:
Position:
Group Leader
Office:
EM01B51-52
Telephone:
+34 93 40 39008

ICREA Research Professor, ERC Advanced Grant

ICREA
Research Group

Since 2004, working as a Research Professor at ICREA (Catalan Institute for Research and Advanced Studies) and Principal Investigator and Programme Coordinator at the Oncology Programme at the Institute for Research in Biomedicine (IRB Barcelona).

1994-1999 PhD fellow at Institut Municipal de Investigació Mèdica (IMIM). 1993 BSc. Universitat de Barcelona. 1999: Associate professor in Biochemistry –Life Siciences at the University Pompeu Fabra, Barcelona. 1999- 2000 PostDoctoral Fellow at Miguel Beato’s group- Institut für Molekularbiologie und Tumorforschung, Marburg. Germany. 2000-2004: PostDoctoral Fellow at Hans Clevers Lab, Netherlands Institute for Developmental Biology, Utrecht, NL.

Research activity in the last ten years has focused on the characterization of the mechanisms that drive colorectal cancer initiation and progression. Among other findings, Eduard Batlle originally discovered the transcription factor Snail as a suppressor of E-cadherin expression in tumor cells and more recently the role of EphB receptors in colorectal cancer. His articles published in the last six years have been quoted more than 800 times and have received several reviews and comments in prestigious journals.

Current researcher's video

Selected group publications

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Cañellas-Socias A, Cortina C, Hernando-Momblona X, Palomo-Ponce S, Mulholland EJ, Turon G, Mateo L, Conti S, Roman O, Sevillano M, Slebe F, Stork D, Caballé-Mestres A, Berenguer-Llergo A, Álvarez-Varela A, Fenderico N, Novellasdemunt L, Jiménez-Gracia L, Sipka T, Bardia L, Lorden P, Colombelli J, Heyn H, Trepat X, Tejpar S, Sancho E, Tauriello DVF, Leedham S, Attolini CS, Batlle E
Nature
611
(7936 )
603 -
613
(2022)
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E
Nature Cancer
3
(9 )
1052 -
+
(2022)
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Herpers B, Eppink B, James MI, Cortina C, Cañellas-Socias A, Boj SF, Hernando-Momblona X, Glodzik D, Roovers RC, van de Wetering M, Bartelink-Clements C, Zondag-van der Zande V, Mateos JG, Yan K, Salinaro L, Basmeleh A, Fatrai S, Maussang D, Lammerts van Bueren JJ, Chicote I, Serna G, Cabellos L, Ramírez L, Nuciforo P, Salazar R, Santos C, Villanueva A, Stephan-Otto Attolini C, Sancho E, Palmer HG, Tabernero J, Stratton MR, de Kruif J, Logtenberg T, Clevers H, Price LS, Vries RGJ, Batlle E, Throsby M
Nature Cancer
3
(4 )
418 -
+
(2022)
Overcoming TGF beta-mediated immune evasion in cancer
Tauriello, DVF; Sancho, E; Batlle, E
Nature Reviews Cancer
22
(1 )
25 -
44
(2021)
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral C; Stanisavljevic J; Hernando-Momblona X; Mereu E; Álvarez-Varela A; Cortina C; Stork D; Slebe F; Turon G; Whissell G; Sevillano M; Merlos-Suárez A; Casanova-Martí À; Moutinho C; Lowe SW; Dow LE; Villanueva A; Sancho E; Heyn H; Batlle E
Cell Stem Cell
26
(6 )
845 -
+
(2020)