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A l'avantguarda de la biomedicina

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Dra. Cristina Mayor-Ruiz

Unit:
Position:
Junior Group Leader
Office:
EM01B24
Telephone:
+34 93 40 24562
BIST
Research Group

Cristina Mayor-Ruiz obtained her PhD in 2017 at the CNIO (Madrid) under the supervision of Óscar Fernández-Capetillo, exploring mechanisms of resistance to genotoxic and targeted anticancer therapies. In 2018, she joined the group of Georg Winter at CeMM (Vienna) supported by EMBO and Marie Curie postdoctoral fellowships, where her research interests focused on different aspects of chemical biology and targeted protein degradation.

Selected group publications

Identification and selectivity profiling of small-molecule degraders via multi-omics approaches.
Scholes, N. S., Mayor-Ruiz, C. & Winter, G. E.
Cell Chemical Biology
(2021)
Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E
Nat Chem Bio
(2020)
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
Mayor-Ruiz, C.1,*, Jaeger, M.G*, Bauer, S., Brand, M., Sin, C., Hanzl, A., Mueller, A.C., Menche, J., and Winter, G.E.1
1 co-corresponding; *Co-first authors
Molecular Cell
(75 )
849 -
858
(2019)
Identification and characterization of cancer vulnerabilities via targeted protein degradation
Mayor-Ruiz, C., and Winter, G.E
Drug Discov Today Technol
(31 )
81 -
90
(2019)
ERF deletion rescues RAS deficiency in mouse ES cells
Mayor-Ruiz C., Olbrich T., Drosten M., Lecona E., Vega-Sendino M., Ortega S., Dominguez O., Barbacid M., Ruiz S. & Fernandez-Capetillo O
Genes & Dev
(32 )
568 -
576
(2018)