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Recerca

A l'avantguarda de la biomedicina

Dra. Cristina Mayor-Ruiz

Unit:
Position:
Junior Group Leader
Office:
EM01B24
Telephone:
+34 93 40 24562
BIST
Research Group

Cristina Mayor-Ruiz obtained her PhD in 2017 at the CNIO (Madrid) under the supervision of Óscar Fernández-Capetillo, exploring mechanisms of resistance to genotoxic and targeted anticancer therapies. In 2018, she joined the group of Georg Winter at CeMM (Vienna) supported by EMBO and Marie Curie postdoctoral fellowships, where her research interests focused on different aspects of chemical biology and targeted protein degradation.

Selected group publications

Biophysical and computational approaches to study ternary complexes: A 'cooperative relationship' to rationalize targeted protein degradation
Ward JA, Perez-Lopez C, Mayor-Ruiz C
Chembiochem
24
(10 )
e202300163 -
e202300163
(2023)
Molecular glue degraders: From serendipity to hunting and design
Nieto-Barrado L; Domostegui A; Mayor-Ruiz C
In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.
Chapter 6
177 -
204
(2022)
Chasing molecular glue degraders: screening approaches
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C
Chemical Society Reviews
51
(13 )
5498 -
5517
(2022)
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
Scholes NS; Mayor-Ruiz C; Winter GE
Cell Chemical Biology
28
(7 )
1048 -
1060
(2021)
Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E
Nat Chem Bio
(2020)