Publicacions institucionals seleccionades

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M

Nature Metabolism

(11 )

1911 -

1930

(2023)

MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis

Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballé, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR

Nature Cell Biology

(2023)

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing

Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M

Nature Cell Biology

(11 )

(2023)

The impact of rare germline variants on human somatic mutation processes (vol 13, 3724, 2022)

Vali-Pour, M; Park, S; Espinosa-Carrasco, J; Ortiz-Martinez, D; Lehner, B; Supek, F

Nature Communications

(1 )

5448 -

(2023)

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L

Science

380

(6651 )

eadh9351 -

eadh9351

(2023)

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA

Nature Aging

(6 )

688 -

(2023)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR

Nature Communications

(1 )

3318 -

3318

(2023)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M

Nucleic Acids Research

(10 )

4713 -

4725

(2023)

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D

Science

380

(6645 )

597 -

(2023)

López-Güell, K; Battistini, F; Orozco, M

Nucleic Acids Research

(6 )

2633 -

2640

(2023)

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress

Fernández-Alfara, M; Sibilio, A; Martin, J; Uxó, ET; Malumbres, M; Alcalde, V; Chanes, V; Cañellas-Socias, A; Palomo-Ponce, S; Batlle, E; Méndez, R

Embo Journal

(9 )

e111494 -

(2023)

Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG

Ali A, Vineethakumari C, Lacasa C, Lüders J

Nature Communications

(1 )

289 -

289

(2023)

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis

Domingo-Muelas A, Duart-Abadia P, Morante-Redolat JM, Jordán-Pla A, Belenguer G, Fabra-Beser J, Paniagua-Herranz L, Pérez-Villalba A, Álvarez-Varela A, Barriga FM, Gil-Sanz C, Ortega F, Batlle E, Fariñas I

Nature Communications

(1 )

373 -

373

(2023)

Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein

Machón, C; Ruiz-Masó, JA; Amodio, J; Boer, DR; Bordanaba-Ruiseco, L; Bury, K; Konieczny, I; del Solar, G; Coll, M

Nucleic Acids Research

(3 )

1458 -

1472

(2023)

Hallmarks of aging: An expanding universe

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G

Cell

186

(2 )

243 -

278

(2023)

Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

Irazoki A, Gordaliza-Alaguero I, Frank E, Giakoumakis NN, Seco J, Palacín M, Gumà A, Sylow L, Sebastián D, Zorzano A

Nature Communications

(1 )

108 -

(2023)

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

Chen, HA; Ho, YJ; Mezzadra, R; Adrover, JM; Smolkin, R; Zhu, CY; Woess, K; Bernstein, N; Schmitt, G; Fong, L; Luan, W; Wuest, A; Tian, S; Li, X; Broderick, C; Hendrickson, RC; Egeblad, M; Chen, ZH; Alonso-Curbelo, D; Lowe, SW

Cancer Discovery

(2 )

432 -

453

(2023)

Cellular senescence is immunogenic and promotes anti-tumor immunity

Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, Ruano I, Attolini CS, Prats N, López-Domínguez JA, Kovatcheva M, Garralda E, Muñoz J, Caron E, Abad M, Gros A, Pietrocola F, Serrano M

Cancer Discovery

(2 )

410 -

431

(2023)

Implementing re-configurable biological computation with distributed multicellular consortia

Canadell D, Ortiz-Vaquerizas N, Mogas-Diez S, de Nadal E, Macia J, Posas F

Nucleic Acids Research

(21 )

12578 -

12595

(2022)

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X; Tejpar, S; Sancho, E; Tauriello, DVF; Leedham, S; Attolini, CSO; Batlle, E

Nature

611

(7936 )

603 -

613

(2022)

The role of lipids in cancer progression and metastasis

Martin-Perez, M; Urdiroz-Urricelqui, U; Bigas, C; Benitah, SA

Cell Metabolism

(11 )

1675 -

1699

(2022)

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque

Fernández-Torras, A; Duran-Frigola, M; Bertoni, M; Locatelli, M; Aloy, P

Nature Communications

(1 )

5304 -

(2022)

Discovering the drivers of clonal hematopoiesis

Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N

Nature Communications

(1 )

4267 -

(2022)

A single WNT enhancer drives specification and regeneration of the Drosophila wing

Gracia-Latorre, E; Pérez, L; Muzzopappa, M; Milán, M

Nature Communications

(1 )

4794 -

4794

(2022)

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening

Alvarez, MM; Biayna, J; Supek, F

Nature Communications

(1 )

4520 -

(2022)

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy

Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E

Nature Cancer

(9 )

1052 -

(2022)

Mutational signatures are markers of drug sensitivity of cancer cells

Levati, J; Salvadores, M; Fuster-Tormo, F; Supek, F

Nature Communications

(1 )

2926 -

2926

(2022)

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R; Santos, C; Villanueva, A; Attolini, CSO; Sancho, E; Palmer, HG; Tabernero, J; Stratton, MR; de Kruif, J; Logtenberg, T; Clevers, H; Price, LS; Vries, RGJ; Batlle, E; Throsby, M

Nature Cancer

(4 )

418 -

(2022)

Overcoming TGF beta-mediated immune evasion in cancer

Tauriello, DVF; Sancho, E; Batlle, E

Nature Reviews Cancer

(1 )

25 -

(2022)

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Pascual, G; Dominguez, D; Elosua-Bayes, M; Beckedorff, F; Laudanna, C; Bigas, C; Douillet, D; Greco, C; Symeonidi, A; Hernandez, I; Gil, SR; Prats, N; Bescos, C; Shiekhattar, R; Amit, M; Heyn, H; Shilatifard, A; Benitah, SA

Nature

599

(7885 )

485 -

(2021)

The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA

Vera-Otarola, J; Castillo-Vargas, E; Angulo, J; Barriga, FM; Batlle, E; Lopez-Lastra, M

Plos Pathogens

(9 )

e1009931 -

(2021)

In silico saturation mutagenesis of cancer genes

Muiños, F; Martínez-Jiménez, F; Pich, O; Gonzalez-Perez, A; Lopez-Bigas, N

Nature

596

(7872 )

428 -

(2021)

Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M

Developmental Cell

(14 )

2043 -

(2021)

Bioactivity descriptors for uncharacterized chemical compounds

Bertoni, M; Duran-Frigola, M; Badia-i-Mompel, P; Pauls, E; Orozco-Ruiz, M; Guitart-Pla, O; Alcalde, V; Diaz, VM; Berenguer-Llergo, A; Brun-Heath, I; Villegas, N; de Herreros, AG; Aloy, P

Nature Communications

(1 )

3932 -

(2021)

Mitochondrial dynamics and liver cancer

Hernández-Alvarez MI; Zorzano A

Cancers

(11 )

(2021)

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Rol, A; Todorovski, T; Martin-Malpartida, P; Escolà, A; Gonzalez-Rey, E; Aragón, E; Verdaguer, X; Vallès-Miret, M; Farrera-Sinfreu, J; Puig, E; Fernández-Carneado, J; Ponsati, B; Delgado, M; Riera, A; Macias, MJ

Nature Communications

(1 )

1869 -

(2021)

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

Pekmezovic, M; Hovhannisyan, H; Gresnigt, MS; Iracane, E; Oliveira-Pacheco, J; Siscar-Lewin, S; Seemann, E; Qualmann, B; Kalkreuter, T; Müller, S; Kamradt, T; Mogavero, S; Brunke, S; Butler, G; Gabaldón, T; Hube, B

Nature Microbiology

(5 )

643 -

(2021)

Timing the origin of eukaryotic cellular complexity with ancient duplications

Vosseberg, J; van Hooff, JJE; Marcet-Houben, M; van Vlimmeren, A; van Wijk, LM; Gabaldón, T; Snel, B

Nature Ecology & Evolution

(1 )

92 -

100

(2021)

Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer

Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A

Nature Cancer

(1 )

122 -

(2020)

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase

Zimmermann, F; Serna, M; Ezquerra, A; Fernandez-Leiro, R; Llorca, O; Luders, J

Science Advances

(51 )

eabe0894 -

(2020)

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Lynch CJ; Bernad R; Martínez-Val A; Shahbazi MN; Nóbrega-Pereira S; Calvo I; Blanco-Aparicio C; Tarantino C; Garreta E; Richart-Ginés L; Alcazar N; Graña-Castro O; Gómez-Lopez G; Aksoy I; Muñoz-Martín M; Martinez S; Ortega S; Prieto S; Simboeck E; Camasses A; Stephan-Otto Attolini C; Fernandez AF; Sierra MI; Fraga MF; Pastor J; Fisher D; Montserrat N; Savatier P; Muñoz J; Zernicka-Goetz M; Serrano M

Nature Cell Biology

(10 )

1223 -

(2020)

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Pittis, AA; Goh, V; Cebrian-Serrano, A; Wettmarshausen, J; Perocchi, F; Gabaldón, T

Nature Communications

(1 )

4031 -

(2020)

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Mas-Ponte, D; Supek, F

Nature Genetics

(9 )

958 -

(2020)

Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P

Nature Biotechnology

(9 )

1087 -

(2020)

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Morral, C; Stanisavljevic, J; Hernando-Momblona, X; Mereu, E; Alvarez-Varela, A; Cortina, C; Stork, D; Slebe, F; Turon, G; Whissell, G; Sevillano, M; Merlos-Suárez, A; Casanova-Martí, A; Moutinho, C; Lowe, SW; Dow, LE; Villanueva, A; Sancho, E; Heyn, H; Batlle, E

Cell Stem Cell

(6 )

845 -

(2020)

The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer

Pascual, R; Martín, J; Salvador, F; Reina, O; Chanes, V; Millanes-Romero, A; Suñer, C; Fernández-Miranda, G; Bartomeu, A; Huang, YS; Gomis, RR; Méndez, R

Science Advances

(20 )

eaax3868 -

(2020)

Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols

Cabre, A; Rafael, S; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A

Angewandte Chemie (International Ed. Print)

(19 )

7521 -

7527

(2020)

Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers