Publicacions institucionals seleccionades

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Kovatcheva M, Melendez E, Chondronasiou D, Pietrocola F, Bernad R, Caballe A, Junza A, Capellades J, Holguín-Horcajo A, Prats N, Durand S, Rovira M, Yanes O, Stephan-Otto Attolini C, Kroemer G, Serrano M

Nature Metabolism

(11 )

1911 -

1930

(2023)

MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis

Llorente A, Blasco MT, Espuny I, Guiu M, Ballaré C, Blanco E, Caballé A, Bellmunt A, Salvador F, Morales A, Nuñez M, Loren G, Imbastari F, Fidalgo M, Figueras-Puig C, Gibler P, Graupera M, Monteiro F, Riera A, Holen I, Avgustinova A, Di Croce L, Gomis RR

Nature Cell Biology

(2023)

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing

Sanfeliu-Cerdán N, Català-Castro F, Mateos B, Garcia-Cabau C, Ribera M, Ruider I, Porta-de-la-Riva M, Canals-Calderón A, Wieser S, Salvatella X, Krieg M

Nature Cell Biology

(2023)

The impact of rare germline variants on human somatic mutation processes (vol 13, 3724, 2022)

Vali-Pour, M; Park, S; Espinosa-Carrasco, J; Ortiz-Martinez, D; Lehner, B; Supek, F

Nature Communications

(1 )

5448 -

(2023)

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

Naón D, Hernández-Alvarez MI, Shinjo S, Wieczor M, Ivanova S, Martins de Brito O, Quintana A, Hidalgo J, Palacín M, Aparicio P, Castellanos J, Lores L, Sebastián D, Fernández-Veledo S, Vendrell J, Joven J, Orozco M, Zorzano A, Scorrano L

Science

380

(6651 )

eadh9351 -

eadh9351

(2023)

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá P, Mereu E, Bonjoch J, Casado-Peláez M, Prats N, Aguilera M, Reina O, Blanco E, Esteller M, Di Croce L, Heyn H, Solanas G, Benitah SA

Nature Aging

(6 )

688 -

704

(2023)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González L, Díaz L, Pous J, Baginski B, Duran-Corbera A, Scarpa M, Brun-Heath I, Igea A, Martin-Malpartida P, Ruiz L, Pallara C, Esguerra M, Colizzi F, Mayor-Ruiz C, Biondi RM, Soliva R, Macias MJ, Orozco M, Nebreda AR

Nature Communications

(1 )

3318 -

3318

(2023)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna V, Iglesias-Fernández J, Reyes-Fraile L, Villegas N, Guckian K, Seth P, Wan B, Cabrero C, Terrazas M, Brun-Heath I, González C, Sciabola S, Villalobos A, Orozco M

Nucleic Acids Research

(10 )

gkad309 -

gkad309

(2023)

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

Burdziak C, Alonso-Curbelo D, Walle T, Reyes J, Barriga FM, Haviv D, Xie Y, Zhao Z, Zhao CJ, Chen HA, Chaudhary O, Masilionis I, Choo ZN, Gao V, Luan W, Wuest A, Ho YJ, Wei Y, Quail DF, Koche R, Mazutis L, Chaligné R, Nawy T, Lowe SW, Pe'er D

Science

380

(6645 )

eadd5327 -

eadd5327

(2023)

López-Güell, Kim; Battistini, Federica; Orozco, Modesto

Nucleic Acids Research

(6 )

2633 -

2640

(2023)

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress

Fernández‐Alfara, Marcos; Sibilio, Annarita; Martin, Judit; Tusquets Uxó, Elsa; Malumbres, Marina; Alcalde, Victor; Chanes, Verónica; Cañellas‐Socias, Adrià; Palomo‐Ponce, Sergio; Batlle, Eduard; Méndez, Raúl

Embo Journal

(9 )

e111494 -

(2023)

Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG

Ali A, Vineethakumari C, Lacasa C, Lüders J

Nature Communications

(1 )

289 -

289

(2023)

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis

Domingo-Muelas A, Duart-Abadia P, Morante-Redolat JM, Jordán-Pla A, Belenguer G, Fabra-Beser J, Paniagua-Herranz L, Pérez-Villalba A, Álvarez-Varela A, Barriga FM, Gil-Sanz C, Ortega F, Batlle E, Fariñas I

Nature Communications

(1 )

373 -

373

(2023)

Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein

Machón C, Ruiz-Masó JA, Amodio J, Boer DR, Bordanaba-Ruiseco L, Bury K, Konieczny I, Del Solar G, Coll M

Nucleic Acids Research

(3 )

1458 -

1472

(2023)

Hallmarks of aging: An expanding universe

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G

Cell

186

(2 )

243 -

278

(2023)

Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

Irazoki A, Gordaliza-Alaguero I, Frank E, Giakoumakis NN, Seco J, Palacín M, Gumà A, Sylow L, Sebastián D, Zorzano A

Nature Communications

(1 )

108 -

(2023)

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

Chen HA, Ho YJ, Mezzadra R, Adrover JM, Smolkin R, Zhu C, Woess K, Bernstein N, Schmitt G, Fong L, Luan W, Wuest A, Tian S, Li X, Broderick C, Hendrickson RC, Egeblad M, Chen Z, Alonso-Curbelo D, Lowe SW

Cancer Discovery

(2 )

432 -

453

(2023)

Cellular senescence is immunogenic and promotes anti-tumor immunity

Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, Ruano I, Attolini CS, Prats N, López-Domínguez JA, Kovatcheva M, Garralda E, Muñoz J, Caron E, Abad M, Gros A, Pietrocola F, Serrano M

Cancer Discovery

(2 )

410 -

431

(2023)

Implementing re-configurable biological computation with distributed multicellular consortia

Canadell D, Ortiz-Vaquerizas N, Mogas-Diez S, de Nadal E, Macia J, Posas F

Nucleic Acids Research

(21 )

12578 -

12595

(2022)

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Cañellas-Socias A, Cortina C, Hernando-Momblona X, Palomo-Ponce S, Mulholland EJ, Turon G, Mateo L, Conti S, Roman O, Sevillano M, Slebe F, Stork D, Caballé-Mestres A, Berenguer-Llergo A, Álvarez-Varela A, Fenderico N, Novellasdemunt L, Jiménez-Gracia L, Sipka T, Bardia L, Lorden P, Colombelli J, Heyn H, Trepat X, Tejpar S, Sancho E, Tauriello DVF, Leedham S, Attolini CS, Batlle E

Nature

611

(7936 )

603 -

613

(2022)

The role of lipids in cancer progression and metastasis

Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah SA

Cell Metabolism

(11 )

1675 -

1699

(2022)

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque

Fernández-Torras, Adrià; Duran-Frigola, Miquel; Bertoni, Martino; Locatelli, Martina; Aloy, Patrick

Nature Communications

(1 )

5304 -

(2022)

Discovering the drivers of clonal hematopoiesis

Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N

Nature Communications

(1 )

4267 -

(2022)

A single WNT enhancer drives specification and regeneration of the Drosophila wing

Gracia-Latorre E, Pérez L, Muzzopappa M, Milán M

Nature Communications

(1 )

4794 -

4794

(2022)

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening

Alvarez, MM; Biayna, J; Supek, F

Nature Communications

(1 )

4520 -

(2022)

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy

Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E

Nature Cancer

(9 )

1052 -

(2022)

Mutational signatures are markers of drug sensitivity of cancer cells

Levatić J, Salvadores M, Fuster-Tormo F, Supek F

Nature Communications

(1 )

2926 -

2926

(2022)

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Herpers B, Eppink B, James MI, Cortina C, Cañellas-Socias A, Boj SF, Hernando-Momblona X, Glodzik D, Roovers RC, van de Wetering M, Bartelink-Clements C, Zondag-van der Zande V, Mateos JG, Yan K, Salinaro L, Basmeleh A, Fatrai S, Maussang D, Lammerts van Bueren JJ, Chicote I, Serna G, Cabellos L, Ramírez L, Nuciforo P, Salazar R, Santos C, Villanueva A, Stephan-Otto Attolini C, Sancho E, Palmer HG, Tabernero J, Stratton MR, de Kruif J, Logtenberg T, Clevers H, Price LS, Vries RGJ, Batlle E, Throsby M

Nature Cancer

(4 )

418 -

(2022)

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Pascual, G; Dominguez, D; Elosua-Bayes, M; Beckedorff, F; Laudanna, C; Bigas, C; Douillet, D; Greco, C; Symeonidi, A; Hernandez, I; Gil, SR; Prats, N; Bescos, C; Shiekhattar, R; Amit, M; Heyn, H; Shilatifard, A; Benitah, SA

Nature

599

(7885 )

485 -

(2021)

Overcoming TGF beta-mediated immune evasion in cancer

Tauriello, DVF; Sancho, E; Batlle, E

Nature Reviews Cancer

(1 )

25 -

(2021)

The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA

Vera-Otarola, J; Castillo-Vargas, E; Angulo, J; Barriga, FM; Batlle, E; Lopez-Lastra, M

Plos Pathogens

(9 )

e1009931 -

(2021)

In silico saturation mutagenesis of cancer genes

Muiños F; Martínez-Jiménez F; Pich O; Gonzalez-Perez A; Lopez-Bigas N

Nature

596

(7872 )

428 -

(2021)

Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M

Developmental Cell

(14 )

2043 -

(2021)

Bioactivity descriptors for uncharacterized chemical compounds

Bertoni M; Duran-Frigola M; Badia-i-Mompel P; Pauls E; Orozco-Ruiz M; Guitart-Pla O; Alcalde V; Diaz VM; Berenguer-Llergo A; Brun-Heath I; Villegas N; de Herreros AG; Aloy P

Nature Communications

(1 )

3932 -

(2021)

Mitochondrial dynamics and liver cancer

Hernández-Alvarez MI; Zorzano A

Cancers

(11 )

(2021)

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Rol Á; Todorovski T; Martin-Malpartida P; Escolà A; Gonzalez-Rey E; Aragón E; Verdaguer X; Vallès-Miret M; Farrera-Sinfreu J; Puig E; Fernández-Carneado J; Ponsati B; Delgado M; Riera A; Macias MJ

Nature Communications

(1 )

1869 -

(2021)

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

Pekmezovic M; Hovhannisyan H; Gresnigt MS; Iracane E; Oliveira-Pacheco J; Siscar-Lewin S; Seemann E; Qualmann B; Kalkreuter T; Müller S; Kamradt T; Mogavero S; Brunke S; Butler G; Gabaldón T; Hube B

Nature Microbiology

(5 )

643 -

(2021)

Timing the origin of eukaryotic cellular complexity with ancient duplications

Vosseberg J; van Hooff JJE; Marcet-Houben M; van Vlimmeren A; van Wijk LM; Gabaldón T; Snel B

Nature Ecology & Evolution

(1 )

92 -

100

(2021)

Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer

Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A

Nature Cancer

(1 )

122 -

(2020)

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase

Zimmermann F; Serna M; Ezquerra A; Fernandez-Leiro R; Llorca O; Luders J

Science Advances

(51 )

eabe0894 -

(2020)

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Lynch CJ; Bernad R; Martínez-Val A; Shahbazi MN; Nóbrega-Pereira S; Calvo I; Blanco-Aparicio C; Tarantino C; Garreta E; Richart-Ginés L; Alcazar N; Graña-Castro O; Gómez-Lopez G; Aksoy I; Muñoz-Martín M; Martinez S; Ortega S; Prieto S; Simboeck E; Camasses A; Stephan-Otto Attolini C; Fernandez AF; Sierra MI; Fraga MF; Pastor J; Fisher D; Montserrat N; Savatier P; Muñoz J; Zernicka-Goetz M; Serrano M

Nature Cell Biology

(10 )

1223 -

(2020)

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Pittis AA; Goh V; Cebrian-Serrano A; Wettmarshausen J; Perocchi F; Gabaldón T

Nature Communications

(1 )

4031 -

(2020)

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Mas-Ponte D; Supek F

Nature Genetics

(9 )

958 -

(2020)

Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P

Nature Biotechnology

(9 )

1087 -

(2020)

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Morral C; Stanisavljevic J; Hernando-Momblona X; Mereu E; Álvarez-Varela A; Cortina C; Stork D; Slebe F; Turon G; Whissell G; Sevillano M; Merlos-Suárez A; Casanova-Martí À; Moutinho C; Lowe SW; Dow LE; Villanueva A; Sancho E; Heyn H; Batlle E

Cell Stem Cell

(6 )

845 -

(2020)

The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer

Pascual, Rosa; Martin, Judit; Salvador, Fernando; Reina, Oscar; Chanes, Veronica; Millanes-Romero, Alba; Suner, Clara; Fernandez-Miranda, Gonzalo; Bartomeu, Anna; Huang, Yi-Shuian; Gomis, Roger R; Mendez, Raul

Science Advances

(20 )

eaax3868 -

(2020)

Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols

Cabré A; Rafael S; Sciortino G; Ujaque G; Verdaguer X; Lledós A; Riera A

Angewandte Chemie (International Ed. Print)

(19 )

7521 -

7527

(2020)

Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers