OncologyStem cells and cancer

Stem cells and cancer
<p>Aznar Benitah</p>
Group Leader

ICREA Research Professor, ERC Starting Grant

+34 93 40 34021

Adult stem cells ensure maintenance of the tissue and integrity in response to damage. They self-renew, are multipotential, and respond to and repair injuries. The skin and other stratified epithelia as model tissues display a high turnover rate, and contain well-defined populations of adult stem cells (SCs). A key feature of SCs is that they localize to specialized niches, where they remain unspecified but sense the needs of the tissue. Constant tissue replenishment drives a SCs to proliferate, the daughter cells to egress the niche, propagate, and terminally differentiate. Niche adherence, dormancy, activation, and exit, must be finely regulated processes, since loss of this tight control is causative of aging, and the onset and progression of squamous cell carcinomas.

Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing.

stem cells

Epidermal stem cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin-15 and high expression of integrin alpha6, respectively.

We are interested in studying the following questions:

  • What intrinsic (cell autonomous) mechanisms regulate adult stem cell function, and how are they deregulated during ageing and cancer?
  • How do adult stem cells communicate with their local environment (i.e. niche) and how is the system coordinated to dictate stem cell function?
  • What systemic cues communicate with adult stem cells and how do distant adult stem cells either from the same tissue or from different tissues coordinate their function at the level of the whole organism?
  • How does deregulation of pathways that control stem cell behaviour contribute to the maintenance and invasive progression of skin and oral squamous cell carcinomas (SCC)? Is there cancer stem cell heterogeneity in human SCC? If so, what is its significance?

We use a combination of conditional mouse models, primary cell culture (human and mouse), live microscopy, highthroughput genomics and proteomics approaches, and basic molecular biology.

Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, Datta D, Symeonidi A, Castellanos A, Welz PS, Caballero JM, Sassone-Corsi P, Muñoz-Cánoves P and Benitah SA.
Cell, 170 (4), 678-692.e2 (2017)
Rinaldi L, Avgustinova A, Martín M, Datta D, Solanas G, Prats N and Benitah SA.
Elife, 6 (2017)
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L and Benitah SA.
Nature, 541 (7635), 41-45 (2017)
Janich P, Toufighi K, Solanas G, Luis NM, Minkwitz S, Serrano L, Lehner B and Benitah SA.
Cell Stem Cell, 13 (6), 745-53 (2013)
Luis N, Morey L, Di Croce L, Benitah SA
Cell Stem Cell, 1 (11), 16-21 (2012)

This group is financially supported by the following:

  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>DNA damage accumulation (in green) in old mice skin (Guiomar Solanas and Francisca Peixoto, IRB Barcelona)</p>
16 Ago 2017

Varios medios, entre ellos TV3, se han hecho eco de la investigación sobre el ritmo circadiano de las células madre dirigida por Salvador Aznar Benitah en el IRB Barcelona, en colaboración con la U

10 Ago 2017

Una hipótesis ampliamente aceptada sostenía que con el tiempo las células madre dejaban de saber si era de día o de noche (perdían el ritmo circadiano) y dicha pérdida promovía el envejecimiento.

<p>Image: Quo.</p>
12 Jul 2017

La revista Quo dedica un amplio reportaje a los hábitos alimenticios y al conocimiento nutricional, incluyendo información sobre las grasas presentes en los alimentos que consumimos.

<p>Image: Worldwide Cancer Research.</p>
16 Jun 2017

“Worldwide Cancer Research”, dedica un reportaje a la investigación de Salvador Aznar-Benitah sobre dos nuevas proteínas que, si están defectuosas, pueden hacer que el cáncer comience.

Upcoming events

13 Sep
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Speaker: Sebastian Pons, PhD, Principal Investigator, Neural Proliferation Control LAB, IBMB-CSIC
20 Sep
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Speaker: Isabel Almudi, Ph.D. Developmental Biology, Evolutionary Biology Andalusian Center for Developmental Biology, Sevilla, Spain.
27 Sep
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Speaker: Cristina Pujades, Ph.D. Group Leader of the Department of Experimental and Health Sciences, University Pompeu Fabra, PRBB, Barcelona, Spain.