OncologyStem cells and cancer

Stem cells and cancer
<p>Aznar Benitah</p>
Group Leader

ICREA Research Professor, ERC Starting Grant

+34 93 40 34568

Adult stem cells ensure maintenance of the tissue and integrity in response to damage. They self-renew, are multipotential, and respond to and repair injuries. The skin and other stratified epithelia as model tissues display a high turnover rate, and contain well-defined populations of adult stem cells (SCs). A key feature of SCs is that they localize to specialized niches, where they remain unspecified but sense the needs of the tissue. Constant tissue replenishment drives a SCs to proliferate, the daughter cells to egress the niche, propagate, and terminally differentiate. Niche adherence, dormancy, activation, and exit, must be finely regulated processes, since loss of this tight control is causative of aging, and the onset and progression of squamous cell carcinomas.

Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing.

stem cells

Epidermal stem cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin-15 and high expression of integrin alpha6, respectively.

We are interested in studying the following questions:

  • What intrinsic (cell autonomous) mechanisms regulate adult stem cell function, and how are they deregulated during ageing and cancer?
  • How do adult stem cells communicate with their local environment (i.e. niche) and how is the system coordinated to dictate stem cell function?
  • What systemic cues communicate with adult stem cells and how do distant adult stem cells either from the same tissue or from different tissues coordinate their function at the level of the whole organism?
  • How does deregulation of pathways that control stem cell behaviour contribute to the maintenance and invasive progression of skin and oral squamous cell carcinomas (SCC)? Is there cancer stem cell heterogeneity in human SCC? If so, what is its significance?

We use a combination of conditional mouse models, primary cell culture (human and mouse), live microscopy, highthroughput genomics and proteomics approaches, and basic molecular biology.

Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA and Sassone-Corsi P.
Cell, 170 (4), 664-677.e1 (2017)
Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, Datta D, Symeonidi A, Castellanos A, Welz PS, Caballero JM, Sassone-Corsi P, Muñoz-Cánoves P and Benitah SA.
Cell, 170 (4), 678-692.e2 (2017)
Rinaldi L, Avgustinova A, Martín M, Datta D, Solanas G, Prats N and Benitah SA.
Elife, 6 (2017)
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L and Benitah SA.
Nature, 541 (7635), 41-45 (2017)
Janich P, Toufighi K, Solanas G, Luis NM, Minkwitz S, Serrano L, Lehner B and Benitah SA.
Cell Stem Cell, 13 (6), 745-53 (2013)
Luis N, Morey L, Di Croce L, Benitah SA
Cell Stem Cell, 1 (11), 16-21 (2012)

This group is financially supported by the following:

  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Image representing the effects of the circadian clock in ageing (Author: Iris Joval Granollers)</p>
9 Nov 2017

La Vanguardia has asked ICREA researcher Salvador Aznar Benitah, an expert on stem cells and circadian rhythm, for his opinion  about two studies published by British universities that suggest that

4 Nov 2017

The research and science programme “Principio de Incertidumbre” broadcasted by Radio Canal Extremadura has interviewed the ICREA researcher Salvador Aznar Benitah about the circadian rhythm—the sub

<p>Salvador Aznar Benitah leads the Stem Cells and Cancer laboratory at IRB Barcelona</p>
20 Oct 2017

Various media, including El Mundo, have reported on the presentation of the National Research Award of the Caja Rural de Soria Scientific Foundation to ICREA researcher Salvador Aznar-Benitah.

<p>Group leader Salvador Aznar Benitah and first author Gloria Pascual in the Stem Cells and Cancer lab at the IRB Barcelona (M. Minocri, IRB Barcelona)</p>
15 Oct 2017

The radio programme Te doy mi palabra broadcasted by Onda Cero has referred to a study by ICREA researcher Salvador Aznar Benitah.

Upcoming events

24 Nov
Serratosa Room, Parc Científic de Barcelona
Speaker:
Dr Howard T Jacobs – GL Institute of Biotechnology – Prof. of Molecular Biology – Academy Professor- Director of Institute of Biotechnology – University of Helsinki
27 Nov
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Obi Griffith, McDonnell Genome Institute (Washington University School of Medicine)
27 Nov - 29 Nov
Institut d'Estudis Catalans (IEC), Barcelona
Speaker:
Marco Milán, James Sharpe