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Mecanismos de las Enfermedades
Translational Control of Cell Cycle and Differentiation
Imagen
Group Leader
Telephone:
+34 93 40 31900

ICREA Research Professor

Imagen
ICREA

Research information

Background

Recent years have seen a paradigm shift in our understanding of gene activity and regulation. It is now clear that processing of primary transcripts as well as translational control open a myriad of opportunities for gene regulation, which are extensively used in virtually every human gene. However, how these events are regulated and how alterations of these finely tuned processes contribute to physio/pathological processes is not yet well understood.

The primary interest of our group has been to understand the molecular mechanisms that dictate alternative 3’ UTR formation and the temporal and spatial translational control of specific mRNAs during cell cycle progression and chromosome segregation, senescence and related pathologies. Cell cycle progression is programmed, at least in part, by stored silent mRNAs. These mRNAs are not translated en masse at any one time, or even at any one place; rather, their translation is specifically regulated by sequences located at their 3´-untranslated regions (3´-UTRs) and their binding proteins.

Research lines

Our work focuses on four main lines of research:

First, to elucidate the mechanisms underlying the translational control by cytoplasmic polyadenylation cis-acting elements and trans-acting factors:
1) Genome-wide identification of the mRNAs that are regulated by nuclear and cytoplasmic changes in their poly(A) tail length;
2) Determination of the configuration of cis-acting elements that define the temporal and spatial translational regulation;
3) Functional and structural characterization of the ribonucleoprotein (RNPs) complexes that mediate this translational regulation.

Second, to obtain insights in how this translational control circuit regulates cell cycle progression by establishing a molecular circuit, stabilized by positive and negative feed-back loops to generate an irreversible self sustain hysteric system with molecular memory and switch-like phase transitions.

Third, to explore the role of these mRNA processing and translation mechanisms in the reprogramming of gene expression in tumoral events and angiogenesis and the development of tools with prognostic and therapeutic value.

Forth, to study the symmetric distribution of cellular components (research directed by Oriol Gallego, see www.gallegolab.org)
1)A comparative analysis of Multisubunit Tethering Complexes
2)Characterize the interplay between the transport of vesicles and mRNA localization

Selected publications

Pascual, Rosa; Martin, Judit; Salvador, Fernando; Reina, Oscar; Chanes, Veronica; Millanes-Romero, Alba; Suner, Clara; Fernandez-Miranda, Gonzalo; Bartomeu, Anna; Huang, Yi-Shuian; Gomis, Roger R; Mendez, Raul
Science Advances
6
(20 )
eaax3868 -
(2020)
Parras A; Anta H; Santos-Galindo M; Swarup V; Elorza A; Nieto-González J; Picó S; Hernández I; Díaz-Hernández J; Belloc E; Rodolosse A; Parikshak N; Peñagarikano O; Fernández-Chacón R; Irimia M; Navarro P; Geschwind D; Méndez R; Lucas J
Nature
560
(7719 )
441 -
446
(2018)
Weill L; Belloc E; Castellazzi CL; Méndez R
Nature Structural & Molecular Biology
24
(8 )
672 -
681
(2017)
Villanueva, Eneko; Navarro, Pilar; Rovira-Rigau, Maria; Sibilio, Annarita; Mendez, Raul; Fillat, Cristina
Nature Communications
8
(14833 )
14833 -
(2017)
Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar; Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul
Nature Cell Biology
19
(2 )
94 -
105
(2017)
Guillén-Boixet J; Buzon V; Salvatella X; Méndez R
Elife
5
(NOVEMBER2016 )
-
(2016)
Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R
Gastroenterology
150
(4 )
982 -
+
(2016)
Afroz T; Skrisovska L; Belloc E; Guillén-Boixet J; Méndez R; Allain F
Genes & Development
28
(13 )
1498 -
1514
(2014)
Bava, Felice-Alessio; Eliscovich, Carolina; Ferreira, Pedro G; Minana, Belen; Ben-Dov, Claudia; Guigo, Roderic; Valcarcel, Juan; Mendez, Raul
Nature
495
(7439 )
121 -
125
(2013)
Novoa I; Gallego J; Ferreira P; Mendez R
Nature Cell Biology
12
(5 )
447 -
456
(2010)
Eliscovich C; Peset I; Vernos I; Méndez R
Nature Cell Biology
10
(7 )
858 -
865
(2008)
Belloc E; Méndez R
Nature
452
(7190 )
1017 -
1021
(2008)
Piqué M; López J; Foissac S; Guigó R; Méndez R
Cell
132
(3 )
434 -
448
(2008)

Group members

Group Leader
Research Associate
Research Assistant
Postdoctoral Fellow
Postdoctoral Fellow
Postdoctoral Fellow
PhD Student
PhD Student
Lab Technician
Lab Technician
Lab Technician

Group News

IRB Barcelona en los medios
18 Feb 2019
IRB Barcelona en los medios
25 Ene 2019
IRB Barcelona en los medios
27 Abr 2017