Publicacions institucionals seleccionades

Sex and smoking bias in the selection of somatic mutations in human bladder

Calvet, F; Martinez-Illescas, RB; Muiños, F; Tretiakova, M; Latorre-Esteves, ES; Fredrickson, J; Andrianova, M; Pellegrini, S; Huber, AR; Ramis-Zaldivar, JE; An, SC; Thieme, E; Kohrn, BF; Grau, ML; Gonzalez-Perez, A; Lopez-Bigas, N; Risques, RA

Nature,

647

(8089)

436

- 444

(2025-11-13)

TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages

Henriques; A; Salvany-Celades; M; Nieto; P; Palomo-Ponce; S; Sevillano; M; Hernando-Momblona; X; Middendorp-Guerra; E; Llanses Martinez; M; Haak; EM; Nieto; JC; Caratù; G; Marchese; D; Ruiz-Gil; M; Tosi; S; Suckert; T; Badia-Ramentol; J; Caballé-Mestres; A; Sánchez-Zarzalejo; C; Mateo; L; Tauriello; DVF; Riera; A; Sancho; E; Stephan-Otto...

Nature Genetics,

3050

- 3065

(2025-11-07)

A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer

Centonze, Alessia; Roura, Adrià-Jaume; Novillo-Font, Meritxell; Giordano, Cristina; Hernando-Momblona, Xavier; Llanses, Montserrat; Prats, Paula; Sevillano, Marta; Cabot, Débora; Novell, Mireia; Pabst, Gabriel; Andersch, Florian; Cañellas-Socias, Adrià; Zhang, Chong; Giakoumakis, Nikolaos-Nikiforos; Sparks, Hugh; Dunsby, Chris; Colombelli,...

Cancer Discovery,

(2025-10-23)

Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue

Sánchez-Feutrie, M; Romero, M; Veiga, SR; Borràs-Ferré, N; Berrow, N; Ràfols, M; Giménez, N; Rodgers-Furones, A; Sabaté-Pérez, A; Pérez, AR; Cataldo, LR; Burghardt, H; Sebastián, D; Plana, N; Hernández, V; Alcaide, LI; Reina, O; Monte, MJ; Marin, JJG; Palacín, M; Burcelin, R; Antonson, P; Gustafsson, JA; Zorzano, A

Nature Communications,

(1)

7033

(2025-09-04)

Spatiotemporal T-cell tracking for personalized T-cell receptor T-cell therapy designs in childhood cancer

Sentís, I; Melero, JL; Cebria-Xart, A; Grzelak, M; Soto, M; Michel, A; Rovira, Q; Rodriguez-Hernandez, CJ; Caratù, G; Urpi, A; Sauvage, C; Mendizabal-Sasieta, A; Maspero, D; Lavarino, CE; Pascual-Reguant, A; Heredia, AC; Perez, JPM; Mora, J; Harari, A; Nieto, JC; Avgustinova, A; Heyn, H

Annals Of Oncology,

(9)

1096

- 1106

(2025-09-01)

Clonal tracing with somatic epimutations reveals dynamics of blood ageing

Scherer, M; Singh, I; Braun, MM; Szu-Tu, C; Sanchez, PS; Lindenhofer, D; Jakobsen, NA; Körber, V; Kardorff, M; Nitsch, L; Kautz, P; Rühle, J; Bianchi, A; Cozzuto, L; Frömel, R; Beneyto-Calabuig, S; Lareau, C; Satpathy, AT; Beekman, R; Steinmetz, LM; Raffel, S; Ludwig, LS; Vyas, P; Rodriguez-Fraticelli, A; Velten, L

Nature,

643

478

- 487

(2025-05-21)

DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy

Khalil, A; Supek, F

Nature Communications,

(1)

4209

(2025-05-13)

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse

Heras-Murillo, I; Mañanes, D; Munné, P; Núñez, V; Herrera, J; Catalá-Montoro, M; Alvarez, M; del Pozo, MA; Melero, I; Wculek, SK; Sancho, D

Nature Communications,

(1)

3369

(2025-04-09)

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations

Singh, I; Fernandez-Perez, D; Sanchez, PS; Rodriguez-Fraticelli, AE

Cell Stem Cell,

(4)

564

- 580

(2025-04-03)

Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response

Ricolo, D; Casanova, J; Giannios, P

Science Advances,

(13)

eads2086

(2025-03-28)

A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations

Nadal-Ribelles, M; Solé, C; Díez-Villanueva, A; Attolini, CSO; Matas, Y; Steinmetz, L; de Nadal, E; Posas, F

Nature Communications,

(1)

2645

(2025-03-18)

Transcriptional heterogeneity shapes stress-adaptive responses in yeast

Nadal-Ribelles, M; Lieb, G; Solé, C; Matas, Y; Szachnowski, U; Andjus, S; Quintana, M; Romo, M; Herrero, AG; Morillon, A; Pelet, S; de Nadal, E; Posas, F

Nature Communications,

(1)

2631

(2025-03-17)

Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD

Garcia-Cabau C; Bartomeu A; Tesei G; Cheung KC; Pose-Utrilla J; Picó S; Balaceanu A; Duran-Arqué B; Fernández-Alfara M; Martín J; De Pace C; Ruiz-Pérez L; García J; Battaglia G; Lucas JJ; Hervás R; Lindorff-Larsen K; Méndez R; Salvatella X

Nature,

637

(8045)

496

- 503

(2025-01-01)

Five latent factors underlie response to immunotherapy

Usset, Joseph; Rosendahl Huber, Axel; Andrianova, Maria A.; Batlle, Eduard; Carles, Joan; Cuppen, Edwin; Elez, Elena; Felip, Enriqueta; Gómez-Rey, Marina; Lo Giacco, Deborah; Martinez-Jimenez, Francisco; Muñoz-Couselo, Eva; Siu, Lillian L.; Tabernero, Josep; Vivancos, Ana; Muiños, Ferran; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria

Nature Genetics,

56:

2112

- 2120

(2024-09-16)

Comprehensive detection and characterization of human druggable pockets through binding site descriptors

Comajuncosa-Creus, Arnau; Jorba, Guillem; Barril, Xavier; Aloy, Patrick

Nature Communications,

(1)

7917

(2024-09-10)

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

López-Polo, V; Maus, M; Zacharioudakis, E; Lafarga, M; Attolini, CSO; Marques, FDM; Kovatcheva, M; Gavathiotis, E; Serrano, M

Nature Communications,

(1)

7378

(2024-08-27)

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Toledano, Ignasi; Supek, Fran; Lehner, Ben

Nature Genetics,

1914

- 1924

(2024-08-23)

An integrated machine-learning model to predict nucleosome architecture

Sala, A; Labrador, M; Buitrago, D; De Jorge, P; Battistini, F; Heath, IB; Orozco, M

Nucleic Acids Research,

(17)

10132

- 10143

(2024-08-20)

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations

Besedina, Elizaveta; Supek, Fran

Nature Communications,

6139

(2024-07-20)

Cyclometallated Imides as Templates for the H‐Bond Directed Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Methyl, N‐Alkyl and N‐Aryl Imines

Wen, Yisong; Fernández‐Sabaté, Marc; Lledós, Agustí; Sciortino, Giuseppe; Eills, James; Marco‐Rius, Irene; Riera, Antoni; Verdaguer, Xavier

Angewandte Chemie,

(26)

e202404955

(2024-06-21)

Formation of left-handed helices by C2′-fluorinated nucleic acids under physiological salt conditions

El-Khoury, Roberto; Cabrero, Cristina; Movilla, Santiago; Kaur, Harneesh; Friedland, David; Dominguez, Arnau; Thorpe, James D; Roman, Morgane; Orozco, Modesto; Gonzalez, Carlos; Damha, Masad J

Nucleic Acids Research,

(13)

7414

- 7428

(2024-06-14)

CGeNArate: a sequence-dependent coarse-grained model of DNA for accurate atomistic MD simulations of kb-long duplexes

Farre-Gil, David; Arcon, Juan Pablo; Laughton, Charles A; Orozco, Modesto

Nucleic Acids Research,

(12)

6791

- 6801

(2024-05-30)

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis

Demajo, Santiago; Ramis-Zaldivar; Joan Enric, Muiños, Ferran; Grau, Miquel L; Andrianova, Maria; López-Bigas, Núria; González-Pérez, Abel.

Cancer Discovery,

(9)

1717

- 1731

(2024-05-09)

Brain-muscle communication prevents muscle aging by maintaining daily physiology

Kumar, Arun; Vaca-Dempere, Mireia; Mortimer, Thomas; Deryagin, Oleg; Smith, Jacob G.; Petrus, Paul; Koronowski, Kevin B.; Greco, Carolina M.; Segalés, Jessica; Andrés, Eva; Lukesova, Vera; Zinna, Valentina M.; Welz, Patrick-Simon; Serrano, Antonio L.; Perdiguero, Eusebio; Sassone-Corsi, Paolo; Benitah, Salvador Aznar; Muñoz-Cánoves, Pura

Science,

384

(6695)

563

- 572

(2024-05-02)

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

Mortimer, Thomas; Zinna, Valentina M.; Atalay, Muge; Laudanna, Carmelo; Deryagin, Oleg; Posas, Guillem; Smith, Jacob G.; García-Lara, Elisa; Vaca-Dempere, Mireia; Monteiro de Assis, Leonardo Vinícius; Heyde, Isabel; Koronowski, Kevin B.; Petrus, Paul; Greco, Carolina M.; Forrow, Stephen; Oster, Henrik; Sassone-Corsi, Paolo; Welz, Patrick-Simon;...

Cell Stem Cell,

(6)

834

- 849

(2024-05-02)

Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells

Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C

Nucleic Acids Research,

(6)

3375

- 3389

(2024-04-12)

Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation

Mas-Ponte, D; Supek, F

Nucleic Acids Research,

(8)

4393

- 4408

(2024-04-08)

Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter

Rullo-Tubau, Josep; Martinez-Molledo, Maria; Bartoccioni, Paola; Puch-Giner, Ignasi; Arias, Angela; Saen-Oon, Suwipa; Stephan-Otto Attolini, Camille; Artuch, Rafael; Diaz, Lucia; Guallar, Victor; Errasti-Murugarren, Ekaitz; Palacin, Manuel; Llorca, Oscar

Nature Communications,

(1)

2986

(2024-04-06)

The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization

Puerto, M; Shukla, M; Bujosa, P; Pérez-Roldán, J; Torràs-Llort, M; Tamirisa, S; Carbonell, A; Solé, C; Puspo, JA; Cummings, CT; de Nadal, E; Posas, F; Azorín, F; Rowley, MJ

Nucleic Acids Research,

(10)

5596

- 5609

(2024-03-23)

Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues

Sánchez-Guixé, Mònica; Muiños, Ferran; Pinheiro-Santin, Morena; González-Huici, Víctor; Rodriguez-Hernandez, Carlos J.; Avgustinova, Alexandra; Lavarino, Cinzia; González-Pérez, Abel; Mora, Jaume; López-Bigas, Núria

Cancer Discovery,

(6)

953

- 964

(2024-03-19)

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders

Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C

Angewandte Chemie (International Ed. Print),

(12)

e202316730

- e202316730

(2024-03-18)

PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy

Lopez-Dominguez, JA; Chaib, S; Serrano, M

Nature Cancer,

(3)

382

- 383

(2024-03-01)

Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers

Salvadores, M; Supek, F

Nature Cancer,

(2)

330

- 346

(2024-02-01)

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chaib S; López-Domínguez JA; Lalinde-Gutiérrez M; Prats N; Marin I; Boix O; García-Garijo A; Meyer K; Muñoz MI; Aguilera M; Mateo L; Stephan-Otto Attolini C; Llanos S; Pérez-Ramos S; Escorihuela M; Al-Shahrour F; Cash TP; Tchkonia T; Kirkland JL; Abad M; Gros A; Arribas J; Serrano M

Nature Cancer,

(3)

448

- 462

(2024-01-24)

A new paradigm for molecular dynamics databases: the COVID-19 database, the legacy of a titanic community effort

Beltrán, D; Hospital, A; Gelpi, JL; Orozco, M

Nucleic Acids Research,

(D1)

D393

- D403

(2024-01-05)

Recent gene selection and drug resistance underscore clinical adaptation across Candida species

Schikora-Tamarit, MA; Gabaldón, T

Nature Microbiology,

(1)

284

- 307

(2024-01-04)

Mucosal TLR5 activation controls healthspan and longevity

Lim, JS; Jeon, EJ; Go, HS; Kim, HJ; Kim, KY; Nguyen, TQT; Lee, DY; Kim, KS; Pietrocola, F; Hong, SH; Lee, SE; Kim, KS; Park, TS; Choi, DH; Jeong, YJ; Park, JH; Kim, HS; Min, JJ; Kim, YS; Park, JT; Cho, JH; Lee, GW; Lee, JH; Choy, HE; Park, SC; Lee, CH; Rhee, JH; Serrano, M; Cho, KA

Nature Communications,

(1)

- 46

(2024-01-02)

MAF amplification licenses ERa through epigenetic remodelling to drive breast cancer metastasis

Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballè, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR

Nature Cell Biology,

(12)

1833

- 1847

(2023-12-01)

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M

Nature Metabolism,

(11)

1911

- 1930

(2023-11-16)

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing

Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M

Nature Cell Biology,

(11)

1590

- 1599

(2023-11-01)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR

Nature Communications,

(1)

3318

(2023-06-12)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M

Nucleic Acids Research,

(10)

4713

- 4725

(2023-06-09)

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA

Nature Aging,

(6)

688

(2023-06-08)

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L

Science,

380

(6651)

eadh9351

- eadh9351

(2023-06-01)

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D

Science,

380

(6645)

597

(2023-05-12)

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress

Fernández-Alfara, M; Sibilio, A; Martin, J; Uxó, ET; Malumbres, M; Alcalde, V; Chanes, V; Cañellas-Socias, A; Palomo-Ponce, S; Batlle, E; Méndez, R

Embo Journal,

(9)

e111494

(2023-05-02)

López-Güell, K; Battistini, F; Orozco, M